Alterations of White Matter Integrity in Subcortical Ischemic Vascular Disease with and Without Cognitive Impairment: a TBSS Study

2019 ◽  
Vol 67 (4) ◽  
pp. 595-603 ◽  
Author(s):  
Xiaoshuang Liu ◽  
Runtian Cheng ◽  
Li Chen ◽  
Tianyou Luo ◽  
FaJin Lv ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Vascular Disease ◽  
White Matter Integrity

Olfactory Function and Diffusion Tensor Imaging as Markers of Mild Cognitive Impairment in Early Stages of Parkinson's Disease

2021 ◽  
pp. 155005942110582
Author(s):  
Sophie A. Stewart ◽  
Laura Pimer ◽  
John D. Fisk ◽  
Benjamin Rusak ◽  
Ron A. Leslie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Diffusion Tensor Imaging ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Neurodegenerative Disorder ◽  
Diffusion Tensor ◽  
Early Stage ◽  
White Matter Integrity

Parkinson's disease (PD) is a neurodegenerative disorder that is typified by motor signs and symptoms but can also lead to significant cognitive impairment and dementia Parkinson's Disease Dementia (PDD). While dementia is considered a nonmotor feature of PD that typically occurs later, individuals with PD may experience mild cognitive impairment (PD-MCI) earlier in the disease course. Olfactory deficit (OD) is considered another nonmotor symptom of PD and often presents even before the motor signs and diagnosis of PD. We examined potential links among cognitive impairment, olfactory functioning, and white matter integrity of olfactory brain regions in persons with early-stage PD. Cognitive tests were used to established groups with PD-MCI and with normal cognition (PD-NC). Olfactory functioning was examined using the University of Pennsylvania Smell Identification Test (UPSIT) while the white matter integrity of the anterior olfactory structures (AOS) was examined using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) analysis. Those with PD-MCI demonstrated poorer olfactory functioning and abnormalities based on all DTI parameters in the AOS, relative to PD-NC individuals. OD and microstructural changes in the AOS of individuals with PD may serve as additional biological markers of PD-MCI.

scholarly journals White matter integrity and types of memory complaints in mild cognitive impairment

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Seon Young Ryu ◽  
Sang Bong Lee ◽  
Taek Jun Lee ◽  
Yu Jin Jung
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Integrity ◽  
Memory Complaints

scholarly journals Destruction of White Matter Integrity in Patients With Mild Cognitive Impairment and Alzheimer Disease

2014 ◽  
Vol 62 (7) ◽  
pp. 927-933 ◽  
Author(s):  
Xiaoyan Sun ◽  
David Salat ◽  
Kristen Upchurch ◽  
Rebecca Deason ◽  
Neil Kowall ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Alzheimer Disease ◽  
White Matter Integrity

P2-065: Volume loss and parahippocampal white matter integrity in amnestic mild cognitive impairment

2008 ◽  
Vol 4 ◽  
pp. T386-T386
Author(s):  
Emily J. Rogalski ◽  
Chris M. Murphy ◽  
Leyla de Toledo-Morrell ◽  
Raj C. Shah ◽  
Mehul A. Trivedi ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Integrity ◽  
Volume Loss

scholarly journals MRI Markers for Mild Cognitive Impairment: Comparisons between White Matter Integrity and Gray Matter Volume Measurements

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66367 ◽  
Author(s):  
Yu Zhang ◽  
Norbert Schuff ◽  
Monica Camacho ◽  
Linda L. Chao ◽  
Thomas P. Fletcher ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Integrity ◽  
Matter Volume ◽  
Volume Measurements

scholarly journals Altered Frequency-Dependent Brain Activation and White Matter Integrity Associated With Cognition in Characterizing Preclinical Alzheimer’s Disease Stages

2021 ◽  
Vol 15 ◽  
Author(s):  
Siyu Wang ◽  
Jiang Rao ◽  
Yingying Yue ◽  
Chen Xue ◽  
Guanjie Hu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Activation ◽  
Amnestic Mild Cognitive Impairment ◽  
White Matter Integrity ◽  
Correlation Analyses ◽  
Preclinical Ad

BackgroundSubjective cognitive decline (SCD), non-amnestic mild cognitive impairment (naMCI), and amnestic mild cognitive impairment (aMCI) are regarded to be at high risk of converting to Alzheimer’s disease (AD). Amplitude of low-frequency fluctuations (ALFF) can reflect functional deterioration while diffusion tensor imaging (DTI) is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 (0.027–0.073 Hz) and slow-5 (0.01–0.027 Hz) bands and white matter fiber integrity among normal controls (CN), SCD, naMCI, and aMCI groups. Correlation analyses were further utilized among paired DTI alteration, ALFF deterioration, and cognitive decline.ResultsFor ALFF calculation, ascended ALFF values were detected in the lingual gyrus (LING) and superior frontal gyrus (SFG) within SCD and naMCI patients, respectively. Descended ALFF values were presented mainly in the LING, SFG, middle frontal gyrus, and precuneus in aMCI patients compared to CN, SCD, and naMCI groups. For DTI analyses, white matter alterations were detected within the uncinate fasciculus (UF) in aMCI patients and within the superior longitudinal fasciculus (SLF) in naMCI patients. SCD patients presented alterations in both fasciculi. Correlation analyses revealed that the majority of these structural and functional alterations were associated with complicated cognitive decline. Besides, UF alterations were correlated with ALFF deterioration in the SFG within aMCI patients.ConclusionsSCD shares structurally and functionally deteriorative characteristics with aMCI and naMCI, and tends to convert to either of them. Furthermore, abnormalities in white matter fibers may be the structural basis of abnormal brain activation in preclinical AD stages. Combined together, it suggests that structural and functional integration may characterize the preclinical AD progression.

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