In-situ synthesized carboxymethyl chitosan/poly(vinyl alcohol) bio-nanocomposite hydrogels containing nanoparticles with drug-delivery properties

2020 ◽  
Vol 43 (1) ◽  
Author(s):  
Iman Gholamali ◽  
Manzarbanou Asnaashariisfahani ◽  
Eskandar Alipour ◽  
Abbas Akhavan Sepahi
Keyword(s):  
Drug Delivery ◽  
Vinyl Alcohol ◽  
Carboxymethyl Chitosan ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels

scholarly journals In Situ Preparation and Properties of Poly(vinyl alcohol)/Carboxymethyl Chitosan/Cyanidin Hydrogel Films

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Xiaojuan Zhang ◽  
Wenbin Cai ◽  
Lingyun Hao ◽  
Wei Zhang
Keyword(s):  
Vinyl Alcohol ◽  
Encapsulation Efficiency ◽  
Umbilical Vein ◽  
Antibacterial Activities ◽  
Carboxymethyl Chitosan ◽  
Poly Vinyl Alcohol ◽  
In Situ Preparation ◽  
Umbilical Vein Endothelial Cells ◽  
Hydrogel Films

This study synthesized poly(vinyl alcohol)/carboxymethyl chitosan/cyanidin (PVA/CMCS/CY) hydrogel films. First, PVA and CMCS were used to synthesize hydrogel films by ultraviolet irradiation. Meanwhile, CY was in situ combined into the hydrogel films through the electrostatic attraction between CMCS and CY. Next, the products were analyzed using Fourier-transform infrared spectroscopy, scanning electron microscopy, contact angle test, swelling analysis, and mechanical property test. The results revealed that compared with PVA/CMCS hydrogel films, the PVA/CMCS/CY hydrogel films had an interporous structure and good swelling and mechanical properties. Moreover, the drug release experiments demonstrated that the PVA/CMCS/CY hydrogel films had a CY encapsulation efficiency of 33.5% with a sustained CY release of up to 60 h. Furthermore, the examined antibacterial activities against Staphylococcus aureus and Escherichia coli showed that the porous PVA/CMCS/CY hydrogel films exhibited a certain inhibition. Cell viability experiments demonstrated that the PVA/CMCS/CY films displayed no obvious cytotoxicity to human umbilical vein endothelial cells.

Anti‐bacterial poly(vinyl alcohol) nanocomposite hydrogels reinforced with in situ synthesized silver nanoparticles

2018 ◽  
Vol 40 (4) ◽  
pp. 1322-1328 ◽  
Author(s):  
Atena Golabdar ◽  
Hossein Adelnia ◽  
Nooshafarin Moshtzan ◽  
Jaber Nasrollah Gavgani ◽  
Hossein Izadi‐Vasafi
Keyword(s):  
Silver Nanoparticles ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Nanocomposite Hydrogels
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