Exploration of the role of disorder and the behaviour of the surface state in the three-dimensional topological insulator—Bi2Se3

This study tests some hypotheses included in the psycho-social-communicational paradigm, which emphasizes the cognitive effects of the media and the role of the psychosocial subject as the recipient

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Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

Current Medicinal Chemistry ◽

10.2174/0929867327666201102115327 ◽

2020 ◽

Vol 27 ◽

Author(s):

Ji-Yeon Lee ◽

Myoung Hee Kim

Keyword(s):

Breast Cancer ◽

Hox Genes ◽

Therapeutic Potential ◽

Expression Patterns ◽

Genome Structure ◽

Control Cell ◽

Three Dimensional ◽

Cellular Processes ◽

Hox Protein

: HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer; they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs, embedded within the HOX cluster, and the role of these molecules in breast cancer have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.

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Central ossifying fibroma of mandible

BMJ Case Reports ◽

10.1136/bcr-2020-239286 ◽

2020 ◽

Vol 13 (12) ◽

pp. e239286

Author(s):

Kumar Nilesh ◽

Prashant Punde ◽

Nitin Shivajirao Patil ◽

Amol Gautam

Keyword(s):

Fibrous Tissue ◽

Three Dimensional ◽

Facial Asymmetry ◽

Ossifying Fibroma ◽

Mandible Reconstruction ◽

Three Dimensional Printing ◽

Osseous Lesion ◽

Large Size ◽

Dimensional Printing

Ossifying fibroma (OF) is a rare, benign, fibro-osseous lesion of the jawbone characterised by replacement of the normal bone with fibrous tissue. The fibrous tissue shows varying amount of calcified structures resembling bone and/or cementum. The central variant of OF is rare, and shows predilection for mandible among the jawbone. Although it is classified as fibro-osseous lesion, it clinically behaves as a benign tumour and can grow to large size, causing bony swelling and facial asymmetry. This paper reports a case of large central OF of mandible in a 40-year-old male patient. The lesion was treated by segmental resection of mandible. Reconstruction of the surgical defect was done using avascular fibula bone graft. Role of three-dimensional printing of jaw and its benefits in surgical planning and reconstruction are also highlighted.

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Charge algebra in Al(A)dSn spacetimes

Journal of High Energy Physics ◽

10.1007/jhep05(2021)210 ◽

2021 ◽

Vol 2021 (5) ◽

Author(s):

Adrien Fiorucci ◽

Romain Ruzziconi

Keyword(s):

Boundary Conditions ◽

Dirichlet Boundary ◽

Three Dimensional ◽

Dirichlet Boundary Conditions ◽

Boundary Structure ◽

Asymptotic Symmetry ◽

Renormalization Procedure ◽

Field Dependent ◽

Odd Dimensions

Abstract The gravitational charge algebra of generic asymptotically locally (A)dS spacetimes is derived in n dimensions. The analysis is performed in the Starobinsky/Fefferman-Graham gauge, without assuming any further boundary condition than the minimal falloffs for conformal compactification. In particular, the boundary structure is allowed to fluctuate and plays the role of source yielding some symplectic flux at the boundary. Using the holographic renormalization procedure, the divergences are removed from the symplectic structure, which leads to finite expressions. The charges associated with boundary diffeomorphisms are generically non-vanishing, non-integrable and not conserved, while those associated with boundary Weyl rescalings are non-vanishing only in odd dimensions due to the presence of Weyl anomalies in the dual theory. The charge algebra exhibits a field-dependent 2-cocycle in odd dimensions. When the general framework is restricted to three-dimensional asymptotically AdS spacetimes with Dirichlet boundary conditions, the 2-cocycle reduces to the Brown-Henneaux central extension. The analysis is also specified to leaky boundary conditions in asymptotically locally (A)dS spacetimes that lead to the Λ-BMS asymptotic symmetry group. In the flat limit, the latter contracts into the BMS group in n dimensions.

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