scholarly journals Fibroblast Growth Factor Signalling in the Diseased Nervous System

2021 ◽  
Author(s):  
Lars Klimaschewski ◽  
Peter Claus
Keyword(s):  
Nervous System ◽  
Imaging Techniques ◽  
Fibroblast Growth ◽  
Maintenance And Repair ◽  
Signalling Molecules ◽  
Mouse Mutants ◽  
Tissue Protection ◽  
Growth Factor Signalling ◽  
Fgf Signalling

AbstractFibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. They influence the intricate relationship between myelinating cells and axons as well as the association of astrocytic and microglial processes with neuronal perikarya and synapses. Advances in molecular genetics and imaging techniques have allowed novel insights into FGF signalling in recent years. Conditional mouse mutants have revealed the functional significance of neuronal and glial FGF receptors, not only in tissue protection, axon regeneration, and glial proliferation but also in instant behavioural changes. This review provides a summary of recent findings regarding the role of FGFs and their receptors in the nervous system and in the pathogenesis of major neurological and psychiatric disorders.

scholarly journals Is Crush Cytology of Central Nervous System Lesions Relevant in Surgical Practice Today?

2019 ◽  
Vol 10 (01) ◽  
pp. 34-38 ◽  
Author(s):  
Krishan Kumar Yadav ◽  
Rashmi Bhatti ◽  
Nikhil Moorchung ◽  
Deepti Mutreja ◽  
Ajay S. Carvalho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Imaging Techniques ◽  
Diagnostic Technique ◽  
High Grade ◽  
Surgical Practice ◽  
The Central Nervous System ◽  
Cns Lesions ◽  
Neurosurgical Intervention

ABSTRACT Background: Intraoperative crush cytology is a useful tool for diagnosing the lesions of the central nervous system (CNS). However, because of the development of newer and better imaging techniques, it is important to evaluate if crush cytology is still relevant in neurosurgical practice. Aims: We evaluated the crush cytology smears in a series of cases where neurosurgical intervention was performed. We studied the role of crush cytology in the intraoperative diagnosis. We report a series of cases where intraoperative crush cytology helped the surgeon revise the surgery during the operation. Materials and Methods: A small portion of all CNS lesions was taken intraoperatively and the tissue was crushed between two slides. The slide was stained using the toluidine blue, Leishman stain, Pap stain and a routine H & E stain. The slides were the evaluated. Results: We evaluated the 50 cases of CNS lesions. We found that intraoperative crush cytology is particularly important in differentiating between neoplastic and nonneoplastic CNS lesions. It may also help in differentiating lymphomas from high-grade gliomas. Finally, crush cytology may help the surgeon in delineating the lesions during surgery. Conclusion: We conclude that crush cytology remains relevant in neurosurgical practice today and it should be adopted in all neurosurgical centers as a routine diagnostic technique.

scholarly journals Fibroblast growth factor signalling in mouse mammary gland development.

2001 ◽  
pp. 211-217 ◽  
Author(s):  
B Spencer-Dene ◽  
C Dillon ◽  
V Fantl ◽  
K Kerr ◽  
A Petiot ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Critical Role ◽  
Mouse Mammary Gland ◽  
Fibroblast Growth ◽  
Aberrant Expression ◽  
Surface Receptors ◽  
Animal Development ◽  
Signalling Molecules ◽  
Growth Factor Signalling ◽  
Intercellular Signalling

Fibroblast growth factors (Fgfs) and their receptors are important intercellular signalling molecules involved in many aspects of animal development. The aberrant expression of the Fgfs or the inappropriate activation of their cell surface receptors have been implicated in tumorigenesis. Here, we describe the evidence that as well as playing a critical role in the formation of the mammary primordia during embryogenesis, signalling by Fgfs is necessary for optimal lobuloalveolar development of the mouse mammary gland during pregnancy.

Sprouty: a controversial role in receptor tyrosine kinase signalling pathways

2003 ◽  
Vol 31 (6) ◽  
pp. 1445-1446 ◽  
Author(s):  
X. Li ◽  
L. Wheldon ◽  
J.K. Heath
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Functional Divergence ◽  
Signalling Pathways ◽  
Signalling Molecules ◽  
Rich Domain ◽  
Growth Factor Signalling ◽  
Cysteine Rich Domain ◽  
Growth Factor Signalling Pathway

Sprouty was first identified in Drosophila as a novel antagonist of the fibroblast growth factor signalling pathway. Sprouty proteins comprise a big family, members of which are characterized by a cysteine-rich domain which confers inhibitory activity, whereas differences in the N-terminal region may be responsible for functional divergence. The role of Sprouty in RTK (receptor tyrosine kinase) signalling pathways is still controversial. Sprouty may negatively or positively regulate RTK signalling via differential interaction with different signalling molecules, and hence exert different mechanism of action.

scholarly journals Role of EGFR in the Nervous System

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1887 ◽  
Author(s):  
Roberta Romano ◽  
Cecilia Bucci
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Epidermal Growth Factor Receptor ◽  
Receptor Tyrosine Kinase ◽  
Growth Factor Receptor ◽  
Maintenance And Repair ◽  
Long Time ◽  
The Central Nervous System ◽  
Epidermal Growth

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation of tissue development and homeostasis has been thoroughly investigated and it has also been demonstrated that EGFR is a driver of tumorigenesis. In the nervous system, other growth factors, and thus other receptors, are important for growth, differentiation and repair of the tissue, namely neurotrophins and neurotrophins receptors. For this reason, for a long time, the role of EGFR in the nervous system has been underestimated and poorly investigated. However, EGFR is expressed both in the central and peripheral nervous systems and it has been demonstrated to have specific important neurotrophic functions, in particular in the central nervous system. This review discusses the role of EGFR in regulating differentiation and functions of neurons and neuroglia. Furthermore, its involvement in regeneration after injury and in the onset of neurodegenerative diseases is examined.

scholarly journals Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Claudia Racioppi ◽  
Ashwani K. Kamal ◽  
Florian Razy-Krajka ◽  
Gennaro Gambardella ◽  
Laura Zanetti ◽  
...  
Keyword(s):  
Nervous System ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Pigment Cell ◽  
Cell Formation ◽  
Ciona Intestinalis ◽  
Fibroblast Growth ◽  
Growth Factor Signalling

scholarly journals The Enteric Nervous System in Inflammation and Pain: The Role of Proteinase-Activated Receptors

2003 ◽  
Vol 17 (10) ◽  
pp. 589-592 ◽  
Author(s):  
Nathalie Vergnolle
Keyword(s):  
Nervous System ◽  
Animal Models ◽  
Enteric Nervous System ◽  
Neurogenic Inflammation ◽  
Pain Perception ◽  
Visceral Pain ◽  
Signalling Molecules ◽  
Proteinase Activated Receptors ◽  
Intestinal Hypersensitivity

The enteric nervous system (ENS) plays a pivotal role in inflammatory and nociceptive processes. Drugs that interact with the ENS have recently raised considerable interest because of their capacity to regulate numerous aspects of the gut physiology and pathophysiology. The present article summarizes recent research on proteinases and proteinase-activated receptors (PARs) as signalling molecules in the ENS. In particular, experiments in animal models suggest that PAR2is important to neurogenic inflammation in the intestine. Moreover, PAR2agonists seem to induce intestinal hypersensitivity and hyperalgesic states, suggesting a role for this receptor in visceral pain perception. Thus, PARs, together with the proteinases that activate them, represent exciting new targets for therapeutic intervention on the ENS.

scholarly journals The Role of Fibroblast Growth Factor Signalling in Osteosarcoma

2011 ◽  
Vol 9 (5) ◽  
pp. 365
Author(s):  
S. Mahalingam ◽  
R. Al-Dabbagh ◽  
D. Weekes ◽  
A.E. Grigoriadis
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Growth Factor Signalling

scholarly journals The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction

2019 ◽  
Vol 13 (3) ◽  
pp. e0006959 ◽  
Author(s):  
Sabine Förster ◽  
Uriel Koziol ◽  
Tina Schäfer ◽  
Raphael Duvoisin ◽  
Katia Cailliau ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Echinococcus Multilocularis ◽  
Fibroblast Growth ◽  
Growth Factor Signalling ◽  
Host Parasite
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