Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy

2015 ◽  
Vol 17 (8) ◽  
pp. 604-611 ◽  
Author(s):  
D. Aydin ◽  
A. Bilici ◽  
D. Yavuzer ◽  
U. Kefeli ◽  
A. Tan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Significance ◽  
Curative Gastrectomy

Prognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy

2019 ◽  
Vol 42 (4) ◽  
pp. 209-216 ◽  
Author(s):  
Ahmet Bilici ◽  
Fatih Selcukbiricik ◽  
Mesut Seker ◽  
Basak B. Oven ◽  
Omer Fatih Olmez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Curative Gastrectomy ◽  
Metastatic Lymph ◽  
Node Ratio

Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 60-60
Author(s):  
Ahmet Bilici ◽  
Dincer Aydin ◽  
Dilek Yavuzer ◽  
Hatice Odabas ◽  
Ozlem Ercelep ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Multivariate Analysis ◽  
Molecular Marker ◽  
Cancer Progression ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Prognostic Indicator ◽  
Curative Gastrectomy ◽  
Prognostic Importance ◽  
Gastric Cancer Patients

60 Background: Tumor invasion and metastasis are complex processes, involving regulation at the molecular level of adhesive molecules, proteolitic enzymes, and cell growth and angiogenesis factors. A Disintegrin and Metalloproteinase (ADAM)17 has been indicated to be indispensable regulator of celular event from proliferation to migration.Although prognostic importance of ADAM17 expression has been investigated in several tumors, its clinical utility as a useful prognostic molecular marker remains unclearin gastric cancer.In the present study, we evaluated the expression of ADAM17 and its prognostic significance in gastric cancer patients after surgery. Methods: Prognostic significance of ADAM17 expression was analyzed by immunohistochemically in 158 patients with gastric cancer and the relationship between its expression and clinicopathological factors was also evaluated. Results: High expression of ADAM17 was detected in 81 patients(51%),while low expression was found in 77 cases (49%). There was significant correlation between gender, histology, lymph node metastasis, vascular invasion, the presence of recurrence and high ADAM17 expression. Recurrence in patients with high ADAM17 expression was significantly higher than that for patients with low ADAM17 expression(p=0.032). The median disease-free survival (DFS) time for patients with high ADAM17 expressed tumors were worse than those of patients with low ADAM17 expressed tumor (16.6 vs. 44.2 months, p=0.004).In addition, patients with low ADAM17 expression had a higher median overall survival (OS)interval than those of high ADAM17 expressed patients (49.6 vs. 26.9 months, p=0.019). Multivariate analysis indicated that the rate of ADAM17 expression was an independent prognostic factor for DFS, in addition to known important clinicopathological prognostic indicator for DFS. But its' prognostic importance could not be proved by multivariate analysis for OS. Conclusions: The potential value of ADAM17 expression as a useful molecular marker in gastric cancer progression should be evaluated comprehensively,it may predict recurrence and poor prognosis in patients with gastric cancer after curative resection.

scholarly journals The prognostic significance of macroscopic serosal change in subserosal invasion (stage T3) gastric cancer

2019 ◽  
Vol 101 (4) ◽  
pp. 249-255 ◽  
Author(s):  
B Zhao ◽  
D Mei ◽  
J Zhang ◽  
S Zou ◽  
Hn Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumour Size ◽  
Prognostic Significance ◽  
Advanced Stage ◽  
Tumour Invasion ◽  
Curative Gastrectomy ◽  
Serosal Surface ◽  
Invasion Stage ◽  
Pathological Evaluation ◽  
Unfavourable Prognosis

Background For patients with gastric cancer intraoperative macroscopic serosal change is not always consistent with pathological T stage. We investigated whether macroscopic serosal change is associated with unfavourable prognosis of patients with gastric cancer. Methods We reviewed 856 patients with stage T3 gastric cancer who underwent curative gastrectomy in our institution. All patients were classified as serosa negative and serosa positive according to the macroscopic serosal change during the operation. The prognostic difference between two groups was compared and clinicopathologic features were analysed. Results The percentage of macroscopic serosal change accounted for 55.7% of all patients. Compared with normal serosal surface, the patients with macroscopic serosal change had larger tumour size, more extensive stomach involvement and more advanced stage N. The prognosis of stage T3 with macroscopic serosal change was significantly poorer than that of those with normal serosal surface, especially for those with stages T3N0 and T3N1. Multivariate analysis identified macroscopic serosal change as an independent factor associated with unfavourable prognosis of stage T3 cancer. Conclusion Although the depth of tumour invasion mainly depends on pathological evaluation after surgery, the prognostic significance of intraoperative macroscopic serosal change should not be ignored for those patients with subserosal invasion.

Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy

2012 ◽  
Vol 57 (6) ◽  
pp. 1568-1575 ◽  
Author(s):  
Ahmet Bilici ◽  
Bala Basak Oven Ustaalioglu ◽  
Dilek Yavuzer ◽  
Mesut Seker ◽  
Alpaslan Mayadagli ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Significance ◽  
Regenerating Liver ◽  
Curative Gastrectomy ◽  
Phosphatase Of Regenerating Liver

Prognostic significance of tumour infiltration growth pattern in patients with advanced gastric cancer

2018 ◽  
Vol 72 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Bochao Zhao ◽  
Jiale Zhang ◽  
Di Mei ◽  
Xinyu Huang ◽  
Shihui Zou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Pattern ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Curative Gastrectomy ◽  
Japanese Classification ◽  
Node Metastases ◽  
Infiltration Growth ◽  
Tumour Infiltration ◽  
The Impact

AimsThe prognostic significance of infiltration growth pattern (INF) in patients with gastric cancer (GC) remains controversial. In the present study, we evaluated the impact of INF pattern on the prognosis of patients with advanced GC.MethodsA total of 1455 patients with advanced GC who underwent curative gastrectomy in our institution were retrospectively analysed. All patients were histopathologically classified as INFa/b and INFc pattern according to the Japanese Classification of Gastric Cancer. The prognostic difference between two patterns was compared and clinicopathological features were analysed.ResultsThe prognosis of the patients with INFc pattern was poorer than that of those with INFa/b pattern (5-year disease-free survival, INFa/b: 48.4% vs INFc: 33.5%, p < 0.001), even when they were stratified according to lymph node metastasis and the tumour, node, metastases stage. In addition, the subgroup analysis indicated that INFc pattern was significantly associated with poorer prognosis of T2–T3 stage patients (T2, INFa/b: 72.7% vs INFc: 55.4%; T3, INFa/b: 47.4% vs INFc: 33.5%; p<0.001). However, a similar result was not observed among T4a stage patients (INFa/b: 26.8% vs INFc: 24.8%, p>0.05). The prognosis of T2 stage patients with INFc pattern was similar to that of T3 stage patients with INFa/b pattern (p>0.05). Also, there was no significantly prognostic difference between T3 stage patients with INFc pattern and T4a stage patients (p>0.05). The multivariate analysis indicated that INF pattern was an independent prognostic factor for patients with advanced GC (HR 1.259, 95%CI 1.089 to 1.454).ConclusionIn view of its prognostic significance, histopathological evaluation of INF pattern in surgically resected specimens should be recommended in patients with advanced GC.

scholarly journals Prognostic significance of positive lymph node ratio in patients with pN3 gastric cancer who underwent curative gastrectomy

2017 ◽  
Vol 28 ◽  
pp. iii35-iii36
Author(s):  
Ahmet Bilici ◽  
Mesut Seker ◽  
Basak Oven Ustaalioglu Bala ◽  
Fatih Olmez Omer ◽  
Ozcan Yildiz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Prognostic Significance ◽  
Positive Lymph Node ◽  
Curative Gastrectomy ◽  
Node Ratio

scholarly journals Impact of Lymphovascular Invasion on Survival Outcome in Patients With Gastric Cancer

2020 ◽  
Vol 153 (6) ◽  
pp. 833-841
Author(s):  
Di Mei ◽  
Bochao Zhao ◽  
Jiale Zhang ◽  
Rui Luo ◽  
Huiwen Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymphovascular Invasion ◽  
Prognostic Significance ◽  
Tumor Stage ◽  
Survival Outcome ◽  
Prognostic Information ◽  
Clinicopathologic Characteristics ◽  
Curative Gastrectomy ◽  
Node Negative ◽  
Impact On Survival

Abstract Objectives To evaluate the prognostic significance of lymphovascular invasion (LVI) for patients with gastric cancer (GC). Methods A total of 1,720 consecutive patients who underwent curative gastrectomy were retrospectively identified. The association between LVI and clinicopathologic characteristics was determined and its impact on survival outcome was evaluated. Results LVI was detected in 21.3% of GC patients, 5.9% of patients with early GC, 24.0% of patients with advanced GC, and 6.7% of node-negative patients using H&E staining. Tumor size (odds ratio [OR], 1.509; 95% confidence interval [CI], 1.159-1.965; P &lt; .01), differentiated type (OR, 1.817; 95% CI, 1.377-2.398; P &lt; .001), and the depth of tumor invasion (OR, 3.011; 95% CI, 2.174-4.171; P &lt; .001) were independent predictive factors for LVI. LVI-positive patients have a poorer prognosis than LVI-negative patients, irrespective of tumor stage or lymph node metastasis. LVI was an independent prognostic factor for patients with GC (hazard ratio, 1.299; 95% CI, 1.112-1.518; P &lt; .001). Conclusions LVI provided additional prognostic information for GC patients, and LVI-positive patients should be considered candidates for adjuvant chemotherapy.

scholarly journals RhoA, Claudin 18, and c-MET in Gastric Cancer: Clinicopathological Characteristics and Prognostic Significance in Curative Resected Patients

2021 ◽  
Vol 10 (1) ◽  
pp. 4
Author(s):  
Marina Alessandra Pereira ◽  
Marcus Fernando Kodama Pertille Ramos ◽  
Andre Roncon Dias ◽  
Leonardo Cardili ◽  
Renan Ribeiro e Ribeiro ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Inflammatory Infiltrate ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Venous Invasion ◽  
Molecular Classification ◽  
Clinicopathological Characteristics ◽  
Curative Gastrectomy ◽  
Poorly Differentiated ◽  
Prediction Of Prognosis

Background: Recently, markers related to molecular classification were suggested as promising therapeutic targets for treatment and prediction of prognosis in gastric cancer (GC), including c-MET, RhoA, and Claudin-18 (CLDN18). This study aimed to investigate their expression in GC and its correlation with clinicopathological characteristics and survival. Methods: We retrospectively evaluated GC patients who underwent curative gastrectomy. c-MET, RhoA, and CLDN18 were analyzed through immunohistochemistry (IHC), and groups for analysis were determined according to the median values obtained for each marker. Results: Among the 349 GC evaluated, 180 (51.6%), 59 (16.9%), and 61 (17.5%) patients were completely negative for c-MET, RhoA, and CLDN18, respectively. Total gastrectomy, D1 lymphadenectomy, poorly differentiated histology, and greater inflammatory infiltrate were more frequent in the c-MET-negative group. Diffuse type, greater inflammatory infiltrate, and advanced pT and pTNM stage were associated with low-RhoA GC. The venous invasion was more frequent in the low-CLDN18 group. Furthermore, c-MET was positively correlated with RhoA and negatively with CLDN18. HER2 expression was associated with c-MET-positive and high-CLDN18 GC; and loss of E-cadherin expression in c-MET-negative and low-RhoA GC. c-MET-negative and Low-RhoA were significantly associated with worse disease-free survival. Conclusions: c-MET, RhoA, and CLD18 expression occurred frequently in GC. RhoA GC had distinct clinicopathological characteristics related to prognosis. c-MET and RhoA were associated with survival but were not independent predictors of prognosis.

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