The prognostic significance of macroscopic serosal change in subserosal invasion (stage T3) gastric cancer

Background For patients with gastric cancer intraoperative macroscopic serosal change is not always consistent with pathological T stage. We investigated whether macroscopic serosal change is associated with unfavourable prognosis of patients with gastric cancer. Methods We reviewed 856 patients with stage T3 gastric cancer who underwent curative gastrectomy in our institution. All patients were classified as serosa negative and serosa positive according to the macroscopic serosal change during the operation. The prognostic difference between two groups was compared and clinicopathologic features were analysed. Results The percentage of macroscopic serosal change accounted for 55.7% of all patients. Compared with normal serosal surface, the patients with macroscopic serosal change had larger tumour size, more extensive stomach involvement and more advanced stage N. The prognosis of stage T3 with macroscopic serosal change was significantly poorer than that of those with normal serosal surface, especially for those with stages T3N0 and T3N1. Multivariate analysis identified macroscopic serosal change as an independent factor associated with unfavourable prognosis of stage T3 cancer. Conclusion Although the depth of tumour invasion mainly depends on pathological evaluation after surgery, the prognostic significance of intraoperative macroscopic serosal change should not be ignored for those patients with subserosal invasion.

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Prognostic Significance of Metastatic Lymph Node Ratio in Patients with pN3 Gastric Cancer Who Underwent Curative Gastrectomy

Oncology Research and Treatment ◽

10.1159/000496746 ◽

2019 ◽

Vol 42 (4) ◽

pp. 209-216 ◽

Cited By ~ 4

Author(s):

Ahmet Bilici ◽

Fatih Selcukbiricik ◽

Mesut Seker ◽

Basak B. Oven ◽

Omer Fatih Olmez ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Ratio ◽

Metastatic Lymph Node ◽

Prognostic Significance ◽

Curative Gastrectomy ◽

Metastatic Lymph ◽

Node Ratio

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Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.3_suppl.60 ◽

2015 ◽

Vol 33 (3_suppl) ◽

pp. 60-60

Author(s):

Ahmet Bilici ◽

Dincer Aydin ◽

Dilek Yavuzer ◽

Hatice Odabas ◽

Ozlem Ercelep ◽

...

Keyword(s):

Gastric Cancer ◽

Multivariate Analysis ◽

Molecular Marker ◽

Cancer Progression ◽

Prognostic Significance ◽

Disease Free Survival ◽

Prognostic Indicator ◽

Curative Gastrectomy ◽

Prognostic Importance ◽

Gastric Cancer Patients

60 Background: Tumor invasion and metastasis are complex processes, involving regulation at the molecular level of adhesive molecules, proteolitic enzymes, and cell growth and angiogenesis factors. A Disintegrin and Metalloproteinase (ADAM)17 has been indicated to be indispensable regulator of celular event from proliferation to migration.Although prognostic importance of ADAM17 expression has been investigated in several tumors, its clinical utility as a useful prognostic molecular marker remains unclearin gastric cancer.In the present study, we evaluated the expression of ADAM17 and its prognostic significance in gastric cancer patients after surgery. Methods: Prognostic significance of ADAM17 expression was analyzed by immunohistochemically in 158 patients with gastric cancer and the relationship between its expression and clinicopathological factors was also evaluated. Results: High expression of ADAM17 was detected in 81 patients(51%),while low expression was found in 77 cases (49%). There was significant correlation between gender, histology, lymph node metastasis, vascular invasion, the presence of recurrence and high ADAM17 expression. Recurrence in patients with high ADAM17 expression was significantly higher than that for patients with low ADAM17 expression(p=0.032). The median disease-free survival (DFS) time for patients with high ADAM17 expressed tumors were worse than those of patients with low ADAM17 expressed tumor (16.6 vs. 44.2 months, p=0.004).In addition, patients with low ADAM17 expression had a higher median overall survival (OS)interval than those of high ADAM17 expressed patients (49.6 vs. 26.9 months, p=0.019). Multivariate analysis indicated that the rate of ADAM17 expression was an independent prognostic factor for DFS, in addition to known important clinicopathological prognostic indicator for DFS. But its' prognostic importance could not be proved by multivariate analysis for OS. Conclusions: The potential value of ADAM17 expression as a useful molecular marker in gastric cancer progression should be evaluated comprehensively,it may predict recurrence and poor prognosis in patients with gastric cancer after curative resection.

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Prognostic significance of the concomitant existence of lymphovascular and perineural invasion in locally advanced gastric cancer patients who underwent curative gastrectomy and adjuvant chemotherapy

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyv031 ◽

2015 ◽

Cited By ~ 1

Author(s):

J.-E. Hwang ◽

J.-Y. Hong ◽

J. E. Kim ◽

H.-J. Shim ◽

W.-K. Bae ◽

...

Keyword(s):

Gastric Cancer ◽

Adjuvant Chemotherapy ◽

Advanced Gastric Cancer ◽

Cancer Patients ◽

Perineural Invasion ◽

Locally Advanced ◽

Prognostic Significance ◽

Curative Gastrectomy ◽

Locally Advanced Gastric Cancer ◽

Gastric Cancer Patients

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Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy

Clinical & Translational Oncology ◽

10.1007/s12094-015-1283-1 ◽

2015 ◽

Vol 17 (8) ◽

pp. 604-611 ◽

Cited By ~ 12

Author(s):

D. Aydin ◽

A. Bilici ◽

D. Yavuzer ◽

U. Kefeli ◽

A. Tan ◽

...

Keyword(s):

Gastric Cancer ◽

Prognostic Significance ◽

Curative Gastrectomy

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Prognostic significance of the recurrence pattern and risk factors for recurrence in patients with proximal gastric cancer who underwent curative gastrectomy

Tumor Biology ◽

10.1007/s13277-015-3304-7 ◽

2015 ◽

Vol 36 (8) ◽

pp. 6191-6199 ◽

Cited By ~ 13

Author(s):

Ahmet Bilici ◽

Fatih Selcukbiricik

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Prognostic Significance ◽

Recurrence Pattern ◽

Proximal Gastric Cancer ◽

Curative Gastrectomy ◽

Risk Factors For Recurrence

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Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy

Digestive Diseases and Sciences ◽

10.1007/s10620-012-2076-9 ◽

2012 ◽

Vol 57 (6) ◽

pp. 1568-1575 ◽

Cited By ~ 6

Author(s):

Ahmet Bilici ◽

Bala Basak Oven Ustaalioglu ◽

Dilek Yavuzer ◽

Mesut Seker ◽

Alpaslan Mayadagli ◽

...

Keyword(s):

Gastric Cancer ◽

Prognostic Significance ◽

Regenerating Liver ◽

Curative Gastrectomy ◽

Phosphatase Of Regenerating Liver

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Analysis of the Clinicopathological Features and Prognosis of Pregnancy with Gastric Cancer: A Case-Control Study

10.21203/rs.3.rs-32729/v1 ◽

2020 ◽

Author(s):

Ying Han ◽

Junli Lu ◽

Lei Zhu ◽

Cuiqin Sang ◽

ShuZhen Wang

Keyword(s):

Gastric Cancer ◽

Prognostic Factors ◽

Abdominal Mass ◽

Supportive Therapy ◽

Tumor Stage ◽

Clinicopathological Features ◽

Control Group ◽

Advanced Stage ◽

Curative Gastrectomy ◽

Cancer In Pregnancy

Abstract BackgroundTo summarize the clinicopathological features and prognostic factors of pregnancy with gastric cancer.MethodsThe clinical data of pregnant patients with gastric cancer diagnosed and treated in our hospital from 2009.1 to 2019.12 were analyzed. Two sex-, age-, and stage- matched controls for each case were identified from the medical data. Clinical characteristics, pathological features and prognosis were summarized.ResultsThe median overall survival time of the pregnancy with gastric cancer and the control group were 8.0 months and 11.0 months, respectively (P = 0.05). The advanced stage was associated with poor prognostic factors. Pregnancy with gastric cancer was associated with a longer time from diagnosis to treatment (19.0 days vs 9.0 days, p = 0.012). The median age was 32 years old (26.0ཞ41.0 years old). The diagnosed time of prengnancy week was 9.0 ~ 37.0 weeks. Of 22 patients, 4 patients had gastric cancer family history. Abdominal pain (6/22, 27.3%) was the most common presentation, and other symptoms were nausea and/or vomiting (3/22, 13.6%), nonspecific dyspepsia (3 cases, 13.6%), and melena (1 case, 4.5%). Other 9 patients (41.0%) were identified with metastatic features, including abdominal distention, ascites, abdominal mass, and jaundice. 5 cases(22.7%) received curative gastrectomy, 5 patients (22.7%) received chemotherapy,and other 12 patients (54.6%) received supportive therapy. ConclusionsThe prognosis of patients with gastric cancer in pregnancy is very poor, and patients often cannot be diagnosed in time. The tumor differentiation is poor with advanced stage, always progresses rapidly with high mortality. And the tumor stage was the significant factor influecing the prognosis.

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Prognostic significance of human tissue kallikrein-related peptidases 6 and 10 in gastric cancer

Biological Chemistry ◽

10.1515/hsz-2014-0143 ◽

2014 ◽

Vol 395 (9) ◽

pp. 1087-1093 ◽

Cited By ~ 14

Author(s):

David L. Kolin ◽

Keiyan Sy ◽

Fabio Rotondo ◽

Mena N. Bassily ◽

Kalman Kovacs ◽

...

Keyword(s):

Gastric Cancer ◽

Tissue Microarray ◽

Human Tissue ◽

Serine Proteases ◽

Prognostic Significance ◽

Staining Intensity ◽

Clinicopathological Parameters ◽

Tissue Kallikrein ◽

Advanced Stage ◽

Stage Disease

Abstract The prognosis of patients following surgery for gastric cancer is often poor and is estimated using traditional clinicopathological parameters, which can be inaccurate predictors of future survival. Kallikreins are a group of serine proteases, which are differentially expressed in many human tumors and are being investigated as potential cancer biomarkers. This study assessed the prognostic utility of human tissue kallikrein-like peptidases 6 and 10 (KLK6 and KLK10) and correlated their expression with histopathological and clinical parameters in gastric cancer. We constructed a gastric tumor tissue microarray from 113 gastrectomy specimens and quantified KLK6 and KLK10 expression using immunohistochemistry. To overcome the problem of inter-observer variability and subjectivity in immunohistochemistry interpretation, a whole-slide scanned image of the tissue microarray was analyzed using an automated algorithm to quantify staining intensity. KLK6 expression was positively correlated with nodal involvement (p=0.002) and was predictive of advanced-stage disease (p<0.05). Kaplan-Meier survival curves revealed that tumors expressing high levels of KLK6 were significantly associated with significantly lower overall survival (p=0.04). KLK10 overexpression was also a predictor of advanced-stage disease (p<0.01), but was not significantly correlated with lymph node involvement or survival period. Our results show the potential ability of KLK6 as a prognostic marker for gastric cancer.

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Prognostic significance of tumour infiltration growth pattern in patients with advanced gastric cancer

Journal of Clinical Pathology ◽

10.1136/jclinpath-2018-205403 ◽

2018 ◽

Vol 72 (2) ◽

pp. 165-171 ◽

Cited By ~ 3

Author(s):

Bochao Zhao ◽

Jiale Zhang ◽

Di Mei ◽

Xinyu Huang ◽

Shihui Zou ◽

...

Keyword(s):

Gastric Cancer ◽

Growth Pattern ◽

Prognostic Significance ◽

Disease Free Survival ◽

Curative Gastrectomy ◽

Japanese Classification ◽

Node Metastases ◽

Infiltration Growth ◽

Tumour Infiltration ◽

The Impact

AimsThe prognostic significance of infiltration growth pattern (INF) in patients with gastric cancer (GC) remains controversial. In the present study, we evaluated the impact of INF pattern on the prognosis of patients with advanced GC.MethodsA total of 1455 patients with advanced GC who underwent curative gastrectomy in our institution were retrospectively analysed. All patients were histopathologically classified as INFa/b and INFc pattern according to the Japanese Classification of Gastric Cancer. The prognostic difference between two patterns was compared and clinicopathological features were analysed.ResultsThe prognosis of the patients with INFc pattern was poorer than that of those with INFa/b pattern (5-year disease-free survival, INFa/b: 48.4% vs INFc: 33.5%, p < 0.001), even when they were stratified according to lymph node metastasis and the tumour, node, metastases stage. In addition, the subgroup analysis indicated that INFc pattern was significantly associated with poorer prognosis of T2–T3 stage patients (T2, INFa/b: 72.7% vs INFc: 55.4%; T3, INFa/b: 47.4% vs INFc: 33.5%; p<0.001). However, a similar result was not observed among T4a stage patients (INFa/b: 26.8% vs INFc: 24.8%, p>0.05). The prognosis of T2 stage patients with INFc pattern was similar to that of T3 stage patients with INFa/b pattern (p>0.05). Also, there was no significantly prognostic difference between T3 stage patients with INFc pattern and T4a stage patients (p>0.05). The multivariate analysis indicated that INF pattern was an independent prognostic factor for patients with advanced GC (HR 1.259, 95%CI 1.089 to 1.454).ConclusionIn view of its prognostic significance, histopathological evaluation of INF pattern in surgically resected specimens should be recommended in patients with advanced GC.

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