scholarly journals Differential Expression of EZH2 and H3K27me3 in Oral Verrucous Carcinoma and Oral Verrucous Hyperplasia

2020 ◽  
Author(s):  
Phetmany Sihavong ◽  
Nakarin Kitkumthorn ◽  
Natchalee Srimaneekarn ◽  
Dusit Bumalee ◽  
Puangwan Lapthanasupkul
Keyword(s):  
Differential Expression ◽  
Verrucous Carcinoma ◽  
Verrucous Hyperplasia

scholarly journals Oral Verrucous Carcinoma: A Study of 12 Cases

2010 ◽  
Vol 04 (02) ◽  
pp. 202-207 ◽  
Author(s):  
Alper Alkan ◽  
Emel Bulut ◽  
Omer Gunhan ◽  
Bora Ozden
Keyword(s):  
Verrucous Carcinoma ◽  
Precancerous Lesion ◽  
Excisional Biopsy ◽  
Follow Up Study ◽  
Floor Of The Mouth ◽  
The Past ◽  
Verrucous Hyperplasia ◽  
Retromolar Trigone ◽  
Diagnostic Difficulties

Objectives: The purpose of this clinical study was to identify a clinical and histopathological relationship between verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma.Methods: We evaluated 12 patients who had developed oral verrucous carcinoma in the past 10 years in a follow-up study. In this study, the diagnostic criteria included clinical and histopathological features of the lesions. Each lesion was examined by a single oral pathologist.Results: All the patients were diagnosed with verrucous carcinoma following excisional biopsy. One patient was diagnosed with verrucous hyperplasia and another with verrucous keratosis in their initial histological findings. Mandibular, posterior alveolar crest, and retromolar trigone were the most affected sites (41.6%), followed by the buccal mucosa (16.6%), the palate (16.6%), the floor of the mouth (16.6%), and the lip (8.3%). No patients had evidence of recurrence after treatment.Conclusions: Verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma may not be distinguished clinically or may coexist, resulting in diagnostic difficulties. It should be kept in mind that verrucous hyperplasia may also develop from leukoplakic lesions, and it may transform into verrucous carcinoma or squamous-cell carcinoma, acting as a potential precancerous lesion. (Eur J Dent 2010;4:202-207)

Proliferative Verrucous Leukoplakia and Verrucous Hyperplasia

1994 ◽  
Vol 103 (8) ◽  
pp. 660-663 ◽  
Author(s):  
Valerie A. Murrah ◽  
John G. Batsakis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
De Novo ◽  
Verrucous Carcinoma ◽  
Upper Respiratory Tract ◽  
Early Form ◽  
Considerable Potential ◽  
Proliferative Verrucous Leukoplakia ◽  
Verrucous Hyperplasia ◽  
Upper Respiratory

Proliferative verrucous leukoplakia and hyperplasia are irreversible clinicopathologic lesions of the oral cavity and upper respiratory tract with considerable potential for evolving into verrucous or other forms of squamous cell carcinoma. Proliferative verrucous leukoplakia is a disease of the oral cavity in which verrucous hyperplasia is a part of its developmental spectrum. Verrucous hyperplasia, at other head and neck mucosal sites, may be associated with papillomas or be a de novo lesion. Human papillomavirus, as a cefaclor, plays a role in some of the lesions. In the instance of verrucous hyperplasia, the authors consider it an early form of verrucous carcinoma and recommend it be treated accordingly.

scholarly journals Verrucous Papillary Lesions: Dilemmas in Diagnosis and Terminology

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Thomas George Kallarakkal ◽  
Anand Ramanathan ◽  
Rosnah Binti Zain
Keyword(s):  
Verrucous Carcinoma ◽  
Growth Patterns ◽  
Treatment Modalities ◽  
Clear Understanding ◽  
Tissue Sections ◽  
Viral Aetiology ◽  
Verrucous Hyperplasia ◽  
Potentially Malignant ◽  
Papillary Lesions ◽  
Malignant Lesions

Verrucous papillary lesions (VPLs) of oral cavity are diagnostically challenging as they include a spectrum of benign, potentially malignant, and frankly malignant lesions. A majority of the benign VPLs have viral aetiology and include commonly occurring squamous papilloma along with verruca vulgaris, focal epithelial hyperplasia, and condyloma. Current understanding of potentially malignant VPLs is perplexing and is primarily attributed to the use of confusing and unsatisfactory terminology. Clinically and histologically oral verrucous hyperplasia, a potentially malignant disorder, resembles oral verrucous carcinoma and may be indistinguishable from one another. The most reliable way to separate these entities on routine haematoxylin-eosin stained tissue sections is to recognize the exophytic growth patterns of oral verrucous hyperplasia from the combined exophytic and endophytic growth patterns associated with verrucous carcinoma. A review of the literature showed that there is a lot of confusion regarding the current clinical and histopathological guidelines to diagnose this potentially malignant entity. The criteria elaborated by different authors in establishing the diagnosis of oral verrucous hyperplasia are discussed in detail. A brief overview of the treatment modalities adopted is also discussed. The need for establishing a clear understanding of this potentially malignant entity is stressed as it may have far reaching implications on its management.

Oral Verrucous Hyperplasia: A Case Report

2019 ◽  
Vol 11 (1) ◽  
pp. 56-61
Author(s):  
Dr. Sanjeela Guru ◽  
Dr. Adithya Reddy ◽  
Dr. Shyam Padmanabhan ◽  
Dr. Rakshith Guru
Keyword(s):  
Case Report ◽  
Present Article ◽  
Histopathological Examination ◽  
Verrucous Carcinoma ◽  
Alveolar Ridge ◽  
Histopathologic Examination ◽  
Oral Mucous Membrane ◽  
Verrucous Hyperplasia ◽  
The Right

Oral Verrucous Hyperplasia is considered as an initialtype of verrucous carcinoma, representing a plausible malignant transformationof the oral mucous membrane. Studies have documented that verrucous hyperplasia transforms into verrucous carcinoma quite consistently and hence both theselesions should be managed identically. The present article reports the case of a 62-year-old male patient whoseprimary complaintwas that of a non-scrapableexophytic warty white outgrowth on edentulous alveolar ridge in the right upper posterior tooth region of the jaw. The growth was provisionally diagnosed as Squamous papilloma. Excision of the exophyticlesion was doneand the tissue biopsy sent for histopathological examination. Histopathologic examination suggested that the lesion was Oral Verrucous hyperplasia. 3 month follow-up of the patient revealed no signs of recurrence.

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