Development and Characterization of Starch/Gelatin Microneedle Arrays Loaded with Lecithin–Gelatin Nanoparticles of Losartan for Transdermal Delivery

2020 ◽  
Author(s):  
Ramón Andrés Pineda-Álvarez ◽  
María Josefa Bernad-Bernad ◽  
Isabel Marlen Rodríguez-Cruz ◽  
José Juan Escobar-Chávez
Keyword(s):  
Transdermal Delivery ◽  
Gelatin Nanoparticles ◽  
Microneedle Arrays

scholarly journals Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Vahid Alimardani ◽  
Samira Sadat Abolmaali ◽  
Gholamhossein Yousefi ◽  
Zahra Rahiminezhad ◽  
Mehdi Abedi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Therapeutic Agents ◽  
Inorganic Nanoparticles ◽  
Microneedle Array ◽  
Wide Range ◽  
Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

Synthesis and experimental/computational characterization of sorghum procyanidins–gelatin nanoparticles

2021 ◽  
pp. 116240
Author(s):  
Francisco Javier Carmelo-Luna ◽  
Ana María Mendoza-Wilson ◽  
Gabriela Ramos-Clamont Montfort ◽  
Jaime Lizardi-Mendoza ◽  
Tomás Madera-Santana ◽  
...  
Keyword(s):  
Gelatin Nanoparticles

Development and characterization of nano-emulsions and nano-emulgels for transdermal delivery of statins

2021 ◽  
pp. 1-13
Author(s):  
Mduduzi N. Sithole ◽  
Suzanne Marais ◽  
Sumari M. Maree ◽  
Lissinda H. Du Plessis ◽  
Jeanetta Du Plessis ◽  
...  
Keyword(s):  
Transdermal Delivery

scholarly journals Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis

2017 ◽  
Vol 265 ◽  
pp. 30-40 ◽  
Author(s):  
Patricia González-Vázquez ◽  
Eneko Larrañeta ◽  
Maelíosa T.C. McCrudden ◽  
Courtney Jarrahian ◽  
Annie Rein-Weston ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Transdermal Delivery ◽  
Potential Treatment ◽  
Microneedle Arrays

scholarly journals Transdermal diffusion of xenon from lipophilic solution of capric triglyceride and from water

2018 ◽  
Vol 2 (5) ◽  
pp. 01-04
Author(s):  
Collin Jared ◽  
Diego Luis ◽  
Jonathan Noah ◽  
Benjamin Dylan
Keyword(s):  
Phase Boundary ◽  
Diffusion Coefficients ◽  
Transdermal Delivery ◽  
Permeability Coefficient ◽  
Pharmaceutical Products ◽  
Rat Skin ◽  
Adult Rats ◽  
Franz Diffusion Cells ◽  
Phosphate Buffered Saline

Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water. Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6). Results: Xenon flux (JXe) through skin from the lipophilic solution was 0.036 mg/hour×cm2 and permeability coefficient (Kp) was 0.003 cm/h; JXe through skin from water was 0.029 mg/h×cm2 and the Kp was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h. Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use.

scholarly journals Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro

2017 ◽  
Vol 34 (7) ◽  
pp. 1491-1504 ◽  
Author(s):  
Qian Zhang ◽  
Michael Murawsky ◽  
Terri LaCount ◽  
Jinsong Hao ◽  
Gerald B. Kasting ◽  
...  
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Temperature Gradients ◽  
Temperature Profiles ◽  
Transdermal Delivery System
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