scholarly journals Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Vahid Alimardani ◽  
Samira Sadat Abolmaali ◽  
Gholamhossein Yousefi ◽  
Zahra Rahiminezhad ◽  
Mehdi Abedi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Therapeutic Agents ◽  
Inorganic Nanoparticles ◽  
Microneedle Array ◽  
Wide Range ◽  
Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

scholarly journals Microneedle Array Patches: Characterization and in -vitro Evaluation

2021 ◽  
Vol 30 (1) ◽  
pp. 66-75
Author(s):  
Zainab A. Sadeq
Keyword(s):  
Drug Delivery ◽  
Blood Vessel ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Solid Polymer ◽  
Microneedle Array ◽  
Microneedle Patch ◽  
Novel Drug

 Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle.  Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication

scholarly journals THE THE MICROEMULSION AS A KEY PLAYER IN CONQUERING THE SKIN BARRIER FOR THE AIM OF TRANSDERMAL DELIVERY OF DRUGS: REVIEWING A SUCCESSFUL DECADE

2019 ◽  
pp. 34-48
Author(s):  
RANIA YEHIA ◽  
DALIA A ATTIA
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Barrier ◽  
The Other ◽  
Penetration Enhancers ◽  
The Past ◽  
Transdermal Drug Delivery Systems ◽  
The One

Microemulsion (ME) systems are now considered of the most successful transdermal drug delivery systems. This is due to their nanodroplets size in the one hand and to their composition that enables the use of several mechanistically penetration enhancers in the same formulation on the other hand. This work summarizes the types, properties, and the merits of the use of MEs for transdermal delivery and reviews the successful studies that were performed to deliver several drugs through this important route during the past 10–12 years.

Liposomes and transferosomes: a breakthrough in topical and transdermal delivery

2021 ◽  
Vol 12 (2) ◽  
pp. 145-158
Author(s):  
Rachana Sapkota ◽  
Alekha K Dash
Keyword(s):  
Physicochemical Properties ◽  
Drug Administration ◽  
Transdermal Delivery ◽  
Therapeutic Agents ◽  
Wide Range ◽  
Liposomal Delivery ◽  
The 1960S ◽  
Routes Of Drug Administration

The topical and transdermal routes of drug administration are long known to the field of pharmaceutics. These routes have been explored for the delivery of a wide range of therapeutic agents over centuries. However, the anatomy of the skin and the physicochemical properties of molecules limit their transport via these routes. To overcome these challenges, a nano-phospholipid carrier called liposome was developed in the 1960s. Liposomal delivery of drugs was reported to be limited to the upper layers of skin. This led to the development of self-regulating and self-adaptable vesicles known as transfersomes. This review critically evaluates the barriers in delivery across the skin, recent advancements in liposomes, transfersomes and their impact in the pharmaceutical field.

Transdermal Drug delivery: A step towards treatment of cancer

2021 ◽  
Vol 16 ◽  
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Penetration ◽  
Delivery Systems ◽  
New Developments ◽  
Transdermal Drug Delivery Systems ◽  
Transdermal Route

Background: Transdermal drug delivery is an emerging and tempting system over oral and hypodermic drug delivery system. With the new developments in skin penetration techniques, anticancer drugs ranging from hydrophilic macromolecules to lipophilic drugs can be administered via transdermal route to treat cancer. Objective: In the present review, various approaches to enhance the transdermal delivery of drugs is discussed including the micro and nanotechnology based transdermal formulations like chemotherapy, gene therapy, immunotherapy, phototherapy, vaccines and medical devices. Limitations and advantages of various transdermal technologies is also elaborated. Method: In this review, patent applications and recent literature of transdermal drug delivery systems employed to cure mainly cancer are covered. Results: Transdermal drug delivery systems have proved their potential to cure cancer. They increase the bioavailability of drug by site specific drug delivery and can reduce the side effects/toxicity associated with anticancer drugs. Conclusion: The potential of transdermal drug delivery systems to carry the drug may unclutter novel ways for therapeutic intercessions in various tumors.

scholarly journals Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 402 ◽  
Author(s):  
Seunghee Lee ◽  
Shayan Fakhraei Lahiji ◽  
Jeesu Jang ◽  
Mingyu Jang ◽  
Hyungil Jung
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Irritation ◽  
Skin Penetration ◽  
Therapeutic Drugs ◽  
Dissolving Microneedles ◽  
Materials Used ◽  
Micro Pillars ◽  
Adhesive Materials

The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertion and accurate delivery of encapsulated compounds into the skin. Moreover, the adhesive materials used in patches may cause skin irritation, inflammation, and redness. Therefore, we developed a patchless, micro-pillar integrated DMN (P-DMN) that is simple to fabricate and enhances transdermal drug delivery compared with traditional DMN patches. The micro-pillars were made of polymethyl methacrylate at a height of 300 μm and a base diameter of 500 μm. To fabricate P-DMNs, we employed hyaluronic acid, which is a widely used derma filler and plays a role in tissue re-epithelialization. We demonstrate that utilizing P-DMNs significantly improves the delivery efficiency of an encapsulated drug surrogate (91.83% ± 7.75%) compared with traditional DMNs (64.86% ± 8.17%). Interestingly, P-DMNs remarkably increase the skin penetration accuracy rate of encapsulated drugs, up to 97.78% ± 2.22%, compared with 44.44% ± 7.85% in traditional DMNs. Our findings suggest that P-DMNs could serve as a highly accurate and efficient platform for transdermal delivery of various types of micro- and macro-biomolecules.

scholarly journals Transdermal drug delivery an emerging approach for antipsychotics

2020 ◽  
Vol 11 (4) ◽  
pp. 5615-5625
Author(s):  
Akash Tekawade ◽  
Tanaji Nandgude
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Oral Drug Delivery ◽  
Skin Penetration ◽  
Barrier Properties ◽  
Oral Drug ◽  
Transdermal Drug Delivery System

Transdermal drug delivery system is one of the leading technology which gives extensive benefits compared to other dosage forms. In the case of drugs having a first-pass metabolism problem, small doses of drugs can be delivered. Oral drug delivery is associated with several problems like pain interrelated with the use of injections,needles, and the researchers mainly focus on the development of the transdermal route. The aim is to provide a rationale for improvement of the transdermal system of antipsychotics by highlighting the antipsychotic formulation and safely delivering medications across the skin.The present review emphasis on the latest advances in a transdermal delivery system which acts as a platform for effective transdermal delivery of antipsychotic. By using this technique, the pharmacotherapy of patients who have psychosis can be improved. There are numeral physical methods, and the skin penetration enhancement techniques have been developed that helps in delivering drugs through the skin.This technique helps to alter the barrier properties of skin and improves the penetration of the drug.It majorly highlights the possible role of microneedle in the transdermal system and acts as a different carrier in delivering several therapeutic agents effectively. This article summarizes thenovel transdermal delivery approaches, advantages, and the choice of antipsychotropic drugs.

scholarly journals A Review on Chemical Permeation Enhancers used in the Formulation of Transdermal Drug Delivery System

2021 ◽  
pp. 429-437
Author(s):  
. Shivani ◽  
Ritika Puri
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Free Water ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Penetration Enhancers ◽  
Permeation Enhancers ◽  
Transdermal Drug Delivery System ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Skin penetration enhancement technology is a rapidly evolving area that will greatly increase the quantity of transdermal drug delivery medications. Penetration enhancers are used to facilitate the movement of drugs through the skin barrier. Numerous methods exist for extending partition enhancement. The enhancers' contact with the polar head of the lipid groups is the potential means for increasing the penetration. Penetration enhancers improve the amount of free water molecules between the bilayer, leading to an improvement of the polar drug diffusion cross section. This article focuses on the different compounds assessed for improving penetration activity like sulphoxides, azones, pyrrolidones, alcohols and alkanols, glycols, surfactants and terpenes.

scholarly journals Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Lalit Kumar ◽  
Shivani Verma ◽  
Kajal Joshi ◽  
Puneet Utreja ◽  
Sumit Sharma
Keyword(s):  
Transdermal Delivery ◽  
Skin Barrier ◽  
Oral Route ◽  
Therapeutic Agents ◽  
Bioactive Molecules ◽  
Main Body ◽  
High Concentration ◽  
Polymeric Nanofibers ◽  
Challenges And Opportunities ◽  
Novel Drug

Abstract Background Transdermal delivery of drugs is a quite challenging task for pharmaceutical scientists. The transdermal route is preferred over the oral route due to various advantages like avoidance of the first-pass effect, non-invasiveness, and high patient compliance. Therefore, it is necessary to develop an effective carrier system that enables the effective passage of the drug through the dermal barrier. Main body of abstract Various novel drug delivery systems are used to enhance the permeation of a variety of drugs through the skin barrier. Researchers around the globe have explored nanofibers for the transdermal delivery of various therapeutic agents. Nanofibers are designed to have a high concentration of therapeutic agents in them promoting their flux through various skin layers. Polymeric nanofibers can be explored for the loading of both hydrophilic and lipophilic drugs. Biopolymer-based nanofibers have been also explored for transdermal delivery. They are capable of controlling the release of therapeutic agents for a prolonged time. Short conclusion The literature presented in this review paper provides significant proof that nanofibers will have an intense impact on the transdermal delivery of different bioactive molecules in the future. Graphic abstract

Transdermal delivery of therapeutics through dissolvable gelatin/sucrose films coated on PEGDA microneedle arrays with improved skin permeability

2019 ◽  
Vol 7 (47) ◽  
pp. 7515-7524 ◽  
Author(s):  
Ya Gao ◽  
Mengmeng Hou ◽  
Ruihao Yang ◽  
Lei Zhang ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Permeability ◽  
Microneedle Arrays

Microneedles are primarily designed for enhancing transdermal drug delivery in a minimally invasive manner.

Evaluation of the nucleopolyhedrovirus of Anticarsia gemmatalis as a vector for gene therapy in mammals

2020 ◽  
Vol 20 ◽  
Author(s):  
Cintia N. Parsza ◽  
Diego L. Mengual Gómez ◽  
Jorge Alejandro Simonin ◽  
Mariano Nicolás Belaich ◽  
Pablo Daniel Ghiringhelli
Keyword(s):  
Gene Therapy ◽  
Mammalian Cells ◽  
Insect Cells ◽  
Autographa Californica ◽  
Anticarsia Gemmatalis ◽  
Agricultural Pests ◽  
Mammalian Cell Lines ◽  
Delivery Vector ◽  
Wide Range ◽  
Insect Pathogens

Background: Baculoviruses are insect pathogens with important biotechnological applications that transcend their use as biological controllers of agricultural pests. One species, Autographa californica multiple nucleopolhyedrovirus (AcMNPV) has been extensively exploited as a molecular platform to produce recombinant proteins and as a delivery vector for genes in mammals, because it can transduce a wide range of mammalian cells and tissues without replicating or producing progeny. Objective/Method: To investigate if the budded virions of Anticarsia gemmatalis multiple nucleopolhyedrovirus (AgMNPV) species has the same ability, the viral genome was modified by homologous recombination into susceptible insect cells to integrate reporter genes and then it was evaluated on mammalian cell lines in comparative form with respect to equivalent viruses derived from AcMNPV. Besides, the replicative capacity of AgMNPV´s virions in mammals was determined. Results: The experiments carried out showed that the recombinant variant of AgMNPV transduces and support the expression of delivered genes but not replicates in mammalian cells. Conclusion: Consequently, this insect pathogen is proposed as an alternative of non-infectious viruses in humans to explore new approaches in gene therapy and other applications based on the use of mammalian cells.

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