scholarly journals Author Correction: 23 Factorial Design and Optimization of Effervescent Floating Matrix Tablet of Neratinib

2021 ◽  
Author(s):  
Mohamed Rahamathulla ◽  
Umme Hani ◽  
Ali Alqahtani ◽  
H. V. Gangadharappa ◽  
M. Yasmin Begum ◽  
...  
Keyword(s):  
Factorial Design ◽  
Matrix Tablet ◽  
Design And Optimization ◽  
23 Factorial Design

23 Factorial Design and Optimization of Effervescent Floating Matrix Tablet of Neratinib

2021 ◽  
Author(s):  
Mohamed Rahamathulla ◽  
Umme Hani ◽  
Ali Alqahtani ◽  
Gangadharappa. H.V ◽  
Yasmin Begum M ◽  
...  
Keyword(s):  
Factorial Design ◽  
Matrix Tablet ◽  
Design And Optimization ◽  
23 Factorial Design

Design and Optimization of Curcumin–HPβCD Bioadhesive Vaginal Tablets by 23 Factorial Design: In Vitro and In Vivo Evaluation

2014 ◽  
Vol 10 (1) ◽  
pp. 21-35 ◽  
Author(s):  
Umme Hani ◽  
H. G. Shivakumar ◽  
Atul Srivastava ◽  
Nawaz Mahammed ◽  
Shailesh Thirumaleshwar ◽  
...  
Keyword(s):  
Factorial Design ◽  
In Vivo Evaluation ◽  
Design And Optimization ◽  
23 Factorial Design

Formulation and Evaluation of Nanosuspension of Simvastatin

2015 ◽  
Vol 8 (2) ◽  
pp. 2858-2873
Author(s):  
Rupali L. Shid ◽  
Shashikant N. Dhole ◽  
Nilesh Kulkarni ◽  
Santosh L Shid
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Factorial Design ◽  
Dissolution Rate ◽  
In Vitro Dissolution ◽  
Total Drug ◽  
23 Factorial Design ◽  
Rate Of Dissolution

Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of this study wasto increase the solubility and dissolution rate of simvastatin by the  preparation of nanosuspension by emulsification solvent diffusion method at laboratory scale. Prepared nanosus-pension was evaluated for its particle size and in vitro dissolution study and characterized by zeta potential,differential scanning calorimetry (DSC) and X-Ray diffractometry (XRD), motic digital microscopy, entrapment efficiency, total drug content, saturated solubility study and in vivo study. A 23 factorial design was employed to study the effect of independent variables, amount of SLS (X1), amount of PVPK-30 (X2) and poloxamer-188 (X3) and dependent variables are total drug content and polydispersity Index. The obtained results showed that particle size (nm) and rate of dissolution has been improved when nanosuspension prepared with the higherconcentration of PVPK-30 with the higher concentration of PVP K-30 and Poloxamer-188 and lower concentration of SLS. The particle size and zeta potential of optimized formulation was found to be 258.3 nm and 23.43. The rate of dissolution of the optimized nanosuspension was enhanced (90% in 60min), relative to plain simvastatin  (21% in 60 min), mainly due to the formation of nanosized particles. These results indicate the suitability of 23 factorial  design for preparation of simvastatin loaded nano-suspension significantly improved in vitro dissolution rate and thus possibly enhance fast onset of therapeutic drug effect. In vivo study shows increase in bioavailability in nanosuspension formulation than the plain simvastatin drug.

scholarly journals Development of Kefir beverages: Standardization of process parameters

2016 ◽  
Vol 7 (2) ◽  
pp. 80
Author(s):  
Jaqueline Gilmara Barboza Januário ◽  
Tailana Marin de Lima ◽  
Daiane Aparecida Camargo Portella ◽  
Caroline Barboza Januário ◽  
Suellen Jensen Klososki ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Factorial Design ◽  
Process Parameters ◽  
Titratable Acidity ◽  
Central Point ◽  
Sensory Characteristics ◽  
Acidic Ph ◽  
Fermentation Time ◽  
23 Factorial Design ◽  
Kefir Grains

This study aimed to characterize physico-chemically Kefir grains and standardize the process parameters of the beverages, in order to obtain an optimum product. Kefir grains consisted basically of water (85.61 ± 0.41%) and had an acidic pH (4.45) and low acidity (0.44 ± 0.09% lactic acid). To determine the process parameters, it was used a 23 factorial design with three replications at the central point, being evaluated the amount of grain (2-6%), amount of sugar (10-14%) and fermentation time (18-24 hours) at 25oC. The amount of sugar or grains had no influence on the pH and titratable acidity. A longer fermentation time (24 hours) resulted in products with pH and acidity within the recommended values, while fewer grains (2%) did not result in too firm beverages. The formulation with the best physicochemical and sensory characteristics had 2% grain, 10% sugar and 24 hours of fermentation, being described as creamy, slightly acidic and with intermediate sweetness.

scholarly journals DESIGN, OPTIMIZATION AND EVALUATION OF ACECLOFENAC FAST DISSOLVING TABLETS EMPLOYING STARCH VALERATE–A NOVEL SUPERDISINTEGRANT

2021 ◽  
pp. 168-176
Author(s):  
R. SANTOSH KUMAR ◽  
SHAMBHAVI KANDUKURI ◽  
M. RAMYA ◽  
B. KUSUMA LATHA
Keyword(s):  
Factorial Design ◽  
Immediate Release ◽  
Compression Method ◽  
Disintegration Time ◽  
23 Factorial Design ◽  
Sodium Starch Glycolate ◽  
Wetting Time ◽  
Croscarmellose Sodium ◽  
Dissolution Efficiency

Objective: To synthesize, characterize and evaluate starch valerate as a superdisintegrant in the formulation of aceclofenac fast dissolving tablets by employing 23 factorial design. Methods: Starch valerate was synthesized and its physical and micromeritic properties were performed to evaluate it. The fast dissolving tablet of aceclofenac was prepared by employing starch valerate as a superdisintegrant in different proportions in each case by direct compression method using 23 factorial design for evaluation of tablet parameters like disintegration and dissolution efficiency in 5 min. Results: The starch valerate prepared was found to be fine, amorphous and free flowing. Starch valerate exhibited good swelling in water with swelling index (125.2%). The study of starch valerate was shown by fourier transform infrared spectra (FTIR). The drug content (200±5%), hardness (3.5–4 kg/sq. cm), and friability (<0.15%) has been effective with regard to all the formulated fast dissolving tablets employing starch valerate. The disintegration time of all the formulated tablets was found to be in the range of 14±0.04 to 25.7±0.02 sec. The optimized formulation F4 had the least disintegration time i.e., 12.8±0.02 sec. The wetting time of the tablets was found to be in the range of 76±0.21 to 217±0.17s. The In vitro wetting time was less (i.e., 28±0.02s) in optimized formulation F4. The water absorption ratio of the formulated tablets was found to be in the range of 46±0.12 to 100±0.27%. The percent drug dissolved in the optimized formulation F8 was found to be 99.93% in 5 min. Conclusion: Starch valerate, when combined with sodium starch glycolate, croscarmellose sodium, with aceclofenac, was found to be an effective super disintegrant which improved the dissolution efficiency and could therefore be used in the formulation of quick dissolving tablets to provide immediate release of the contained drug within 5 min.

scholarly journals Application of optimization tools for preparation of nebivolol liquid solid composite compressed tablet

2021 ◽  
Vol 12 (3) ◽  
pp. 1967-1976
Author(s):  
Kumar Babu P ◽  
Venkatachalam A ◽  
Bhaskar Reddy K
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Factorial Design ◽  
Dissolution Rate ◽  
Disintegration Time ◽  
Independent Variables ◽  
23 Factorial Design ◽  
Sustained Release Tablet ◽  
Wetting Time ◽  
Solid Liquid

The purpose of this study is to make Nebivolol more efficient by converting it into a liquid solid composite compressed tablet. Blending cum sonication process was used to create the liquid solid composite. By altering the independent variables such as vehicle, carrier, and superdisintegrants, nearly 12 compositions were created in a 23 factorial design with four centre points. The influence on response, such as disintegration time in seconds and wetting time in seconds, was then determined. In addition, the liquid solid composite was compacted into a tablet and its percent invitro drug release was assessed. Based on disintegration time and wetting time, the optimal solid liquid compacts sustained release tablet formulation was identified to be LSC6 , which may be ideal candidates for boosting the solubility and dissolution rate of less soluble medications like Nebivolol.

scholarly journals Efficiency Improvements of Antenna Optimization Using Orthogonal Fractional Experiments

2015 ◽  
Vol 2015 ◽  
pp. 1-12
Author(s):  
Yen-Sheng Chen ◽  
Ting-Yu Ku
Keyword(s):  
Factorial Design ◽  
Radio Frequency Identification ◽  
Heuristic Algorithms ◽  
Full Factorial Design ◽  
Antenna Design ◽  
Handheld Devices ◽  
Small Subset ◽  
Design And Optimization ◽  
Blind Search ◽  
Full Factorial

This paper presents an extremely efficient method for antenna design and optimization. Traditionally, antenna optimization relies on nature-inspired heuristic algorithms, which are time-consuming due to their blind-search nature. In contrast, design of experiments (DOE) uses a completely different framework from heuristic algorithms, reducing the design cycle by formulating the surrogates of a design problem. However, the number of required simulations grows exponentially if a full factorial design is used. In this paper, a much more efficient technique is presented to achieve substantial time savings. By using orthogonal fractional experiments, only a small subset of the full factorial design is required, yet the resultant response surface models are still effective. The capability of orthogonal fractional experiments is demonstrated through three examples, including two tag antennas for radio-frequency identification (RFID) applications and one internal antenna for long-term-evolution (LTE) handheld devices. In these examples, orthogonal fractional experiments greatly improve the efficiency of DOE, thereby facilitating the antenna design with less simulation runs.

scholarly journals In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin

2005 ◽  
Vol 73 (1) ◽  
pp. 59-74
Author(s):  
Lütfi Genç ◽  
A. Kıran
Keyword(s):  
Drug Release ◽  
Hydroxypropyl Methylcellulose ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Assay Method ◽  
Content Uniformity ◽  
Matrix Tablet ◽  
Compression Technique ◽  
23 Factorial Design

Sustained release matrix tablets of clarithromycin were prepared using different polymers as Hydroxypropyl methylcellulose (H PMC), Carbopol 934 and Eudragit RL/PO by direct compression technique. For the quality control of these formulations, weight deviation, hardness, friability, diameter-height ratio, content uniformity of the active substance and in vitro dissolution technique were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. Dissolution profiles of the tablets were plotted and evaluated kinetically. The effects on drug release of polymer type and concentrations were investigated by 23 factorial design. The tablets containing HPMC, Carbopol 934 and Eudragit RLIPO were found suitably to sustain drug release

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