scholarly journals A high performance bench scale process for isolation from inclusion bodies, refolding and dimerisation of a thiol-engineered recombinant therapeutic protein

2017 ◽  
Vol 22 (4) ◽  
pp. 423-430
Author(s):  
Desmond M. Schofield ◽  
Darren N. Nesbeth
Keyword(s):  
Inclusion Bodies ◽  
High Performance ◽  
Therapeutic Protein ◽  
Bench Scale ◽  
Recombinant Therapeutic Protein

scholarly journals The Different Colors of mAbs in Solution

Antibodies ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 21
Author(s):  
Alexandre Ambrogelly
Keyword(s):  
Visual Inspection ◽  
Quantitative Methods ◽  
Geographical Area ◽  
Therapeutic Protein ◽  
Protein Solutions ◽  
Protein Solution ◽  
Critical Quality Attribute ◽  
Recombinant Therapeutic Protein ◽  
Protein Variants ◽  
Antibody Solution

The color of a therapeutic monoclonal antibody solution is a critical quality attribute. Consistency of color is typically assessed at time of release and during stability studies against preset criteria for late stage clinical and commercial products. A therapeutic protein solution’s color may be determined by visual inspection or by more quantitative methods as per the different geographical area compendia. The nature and intensity of the color of a therapeutic protein solution is typically determined relative to calibrated standards. This review covers the analytical methodologies used for determining the color of a protein solution and presents an overview of protein variants and impurities known to contribute to colored recombinant therapeutic protein solutions.

scholarly journals Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein

2007 ◽  
Vol 124 (1) ◽  
pp. 26-32 ◽  
Author(s):  
E. Koren ◽  
A.S. De Groot ◽  
V. Jawa ◽  
K.D. Beck ◽  
T. Boone ◽  
...  
Keyword(s):  
In Silico ◽  
Therapeutic Protein ◽  
Clinical Validation ◽  
In Silico Prediction ◽  
Recombinant Therapeutic Protein

Characterization of a cathepsin D protease from CHO cell-free medium and mitigation of its impact on the stability of a recombinant therapeutic protein

2017 ◽  
Vol 34 (1) ◽  
pp. 120-129 ◽  
Author(s):  
Amareth Lim ◽  
Brandon L. Doyle ◽  
Gerard M. Kelly ◽  
Angelia M. Reed-Bogan ◽  
Lawrence H. Breen ◽  
...  
Keyword(s):  
Cathepsin D ◽  
Therapeutic Protein ◽  
Free Medium ◽  
Cho Cell ◽  
Recombinant Therapeutic Protein ◽  
The Stability

scholarly journals Establishment and characterization of new human cell lines for recombinant therapeutic protein production

2015 ◽  
Vol 9 (Suppl 9) ◽  
pp. P3
Author(s):  
Yuichi Inoue ◽  
Akira Iwamoto ◽  
Aiko Inoue ◽  
Hiroharu Kawahara
Keyword(s):  
Cell Lines ◽  
Human Cell ◽  
Protein Production ◽  
Therapeutic Protein ◽  
Human Cell Lines ◽  
Recombinant Therapeutic Protein
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