scholarly journals Research progress on interleukin-33 and its roles in the central nervous system

2011 ◽  
Vol 27 (5) ◽  
pp. 351-357 ◽  
Author(s):  
Ping Han ◽  
Wen-Li Mi ◽  
Yan-Qing Wang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Research Progress ◽  
Interleukin 33 ◽  
The Central Nervous System

scholarly journals Research Progress on the Effect of Sphingosine Kinase 2 on Glioma

2021 ◽  
Vol 5 (6) ◽  
pp. 16-19
Author(s):  
Chunpeng Wang ◽  
Xiaohui Liu ◽  
Shiwen Guo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sphingosine Kinase ◽  
Immunohistochemical Method ◽  
Research Progress ◽  
Control Group ◽  
Sphingosine Kinase 2 ◽  
Two Factors ◽  
The Central Nervous System

Objective: The purpose of this study is to explore the role of sphingosine kinase 2 (SphK2) in the treatment of glioma, which is the most common primary tumor in the central nervous system. Methods: A total of 82 patients were included in this study, with 27 cases in the control group and 55 cases in the glioma group; the expressions of SphK2 and gp130 in the two groups were compared by immunohistochemical method, and the correlation between the two factors was analyzed. Results: Both SphK2 and gp130 were upregulated in the glioma group, and the two factors were significantly correlated. Conclusion: The high expression of SphK2 may play an important role in the occurrence, development, and diagnosis of glioma.

scholarly journals Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiangyu Li ◽  
Ming Liu ◽  
Junfeng Zhao ◽  
Tong Ren ◽  
Xin Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Tumor Progression ◽  
Tumor Recurrence ◽  
Research Progress ◽  
Glioma Stem Cells ◽  
Immune Microenvironment ◽  
Primary Tumors ◽  
The Central Nervous System

Gliomas are the most common primary tumors of the central nervous system. Due to the existence of the blood-brain barrier and its unique regional immune characteristics, the study of the immune microenvironment of gliomas is particularly important. Glioma stem cells are an important cause of initiating glioma, promoting tumor progression and leading to tumor recurrence. Immunotherapeutic strategies targeting glioma stem cells have become the focus of current research. This paper will focus on the research progress of glioma stem cells in the immune microenvironment of glioma to provide the basis for the immunotherapy of glioma.

scholarly journals Research Progress on the Neuroprotective Effect of Leonurine on Ischemic Stroke

2021 ◽  
Vol 5 (6) ◽  
pp. 83-85
Author(s):  
Honglong Wu ◽  
Long He ◽  
Zhifen Tan ◽  
Meikui Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Chinese Medicine ◽  
Neuroprotective Effect ◽  
Cerebrovascular Diseases ◽  
Research Progress ◽  
The Central Nervous System ◽  
Clinical Drugs ◽  
Main Component

Leonurus is one of the commonly used clinical drugs in traditional Chinese medicine. In recent years, leonurus has been widely used for cerebrovascular diseases. With the deepening of research, the effect of its main component, leonurine, on the central nervous system has become clearer, and its mechanism has been confirmed and explained from many aspects. For reference, this paper discusses the latest research on the neuroprotective effect of leonurine on ischemic stroke at home and abroad in recent years.

scholarly journals Research Progress in the Effect of Traditional Chinese Medicine for Invigoration on Neurotransmitter Related Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Xiting Zhang ◽  
Lin Li ◽  
Ting Chen ◽  
Zuoyan Sun ◽  
Weiwei Tang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Present Report ◽  
Aminobutyric Acid ◽  
Research Progress ◽  
The Central Nervous System ◽  
Perimenopausal Syndrome

Tonic traditional Chinese medicine is widely used in clinical practice and is categorized into four main drugs, namely, Qi-supplementing, Blood-enriching, Yin-nourishing, and Yang-tonifying. Neurotransmitters play a coordinating role in the nervous system, visceral function, and stress response. The excitation or suppression of the central nervous system is closely related to various diseases, such as insomnia, depression, Alzheimer’s disease, Parkinson’s disease, and perimenopausal syndrome. An increasing amount of evidence shows that Chinese tonic herb and its active ingredients can delay the occurrence and development of these diseases by modulating related neurotransmitters and their receptors, including norepinephrine (NE), serotonin (5-HT), dopamine (DA), acetylcholine (ACh), and γ-aminobutyric acid (GABA). In the present report, studies on the treatment of these neurotransmitter related diseases in relation to the application of tonic Chinese medicine are reviewed.

scholarly journals Therapeutic Opportunities of Interleukin-33 in the Central Nervous System

2021 ◽  
Vol 12 ◽  
Author(s):  
Yun Sun ◽  
Yankai Wen ◽  
Luxi Wang ◽  
Liang Wen ◽  
Wendong You ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebrovascular Diseases ◽  
Receptor Complex ◽  
Functional Roles ◽  
Interleukin 33 ◽  
Current Review ◽  
Signaling Mechanisms ◽  
The Central Nervous System ◽  
Receptor Accessory Protein

Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is involved in various diseases. IL-33 exerts its effects via its heterodimeric receptor complex, which comprises suppression of tumorigenicity 2 (ST2) and the IL-1 receptor accessory protein (IL-1RAP). Increasing evidence has demonstrated that IL-33/ST2 signaling plays diverse but crucial roles in the homeostasis of the central nervous system (CNS) and the pathogenesis of CNS diseases, including neurodegenerative diseases, cerebrovascular diseases, infection, trauma, and ischemic stroke. In the current review, we focus on the functional roles and cellular signaling mechanisms of IL-33 in the CNS and evaluate the potential for diagnostic and therapeutic applications.

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