scholarly journals Research Progress on the Neuroprotective Effect of Leonurine on Ischemic Stroke

2021 ◽  
Vol 5 (6) ◽  
pp. 83-85
Author(s):  
Honglong Wu ◽  
Long He ◽  
Zhifen Tan ◽  
Meikui Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Chinese Medicine ◽  
Neuroprotective Effect ◽  
Cerebrovascular Diseases ◽  
Research Progress ◽  
The Central Nervous System ◽  
Clinical Drugs ◽  
Main Component

Leonurus is one of the commonly used clinical drugs in traditional Chinese medicine. In recent years, leonurus has been widely used for cerebrovascular diseases. With the deepening of research, the effect of its main component, leonurine, on the central nervous system has become clearer, and its mechanism has been confirmed and explained from many aspects. For reference, this paper discusses the latest research on the neuroprotective effect of leonurine on ischemic stroke at home and abroad in recent years.

scholarly journals Research Progress in the Effect of Traditional Chinese Medicine for Invigoration on Neurotransmitter Related Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Xiting Zhang ◽  
Lin Li ◽  
Ting Chen ◽  
Zuoyan Sun ◽  
Weiwei Tang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Practice ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Present Report ◽  
Aminobutyric Acid ◽  
Research Progress ◽  
The Central Nervous System ◽  
Perimenopausal Syndrome

Tonic traditional Chinese medicine is widely used in clinical practice and is categorized into four main drugs, namely, Qi-supplementing, Blood-enriching, Yin-nourishing, and Yang-tonifying. Neurotransmitters play a coordinating role in the nervous system, visceral function, and stress response. The excitation or suppression of the central nervous system is closely related to various diseases, such as insomnia, depression, Alzheimer’s disease, Parkinson’s disease, and perimenopausal syndrome. An increasing amount of evidence shows that Chinese tonic herb and its active ingredients can delay the occurrence and development of these diseases by modulating related neurotransmitters and their receptors, including norepinephrine (NE), serotonin (5-HT), dopamine (DA), acetylcholine (ACh), and γ-aminobutyric acid (GABA). In the present report, studies on the treatment of these neurotransmitter related diseases in relation to the application of tonic Chinese medicine are reviewed.

scholarly journals Research Progress on the Effect of Sphingosine Kinase 2 on Glioma

2021 ◽  
Vol 5 (6) ◽  
pp. 16-19
Author(s):  
Chunpeng Wang ◽  
Xiaohui Liu ◽  
Shiwen Guo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sphingosine Kinase ◽  
Immunohistochemical Method ◽  
Research Progress ◽  
Control Group ◽  
Sphingosine Kinase 2 ◽  
Two Factors ◽  
The Central Nervous System

Objective: The purpose of this study is to explore the role of sphingosine kinase 2 (SphK2) in the treatment of glioma, which is the most common primary tumor in the central nervous system. Methods: A total of 82 patients were included in this study, with 27 cases in the control group and 55 cases in the glioma group; the expressions of SphK2 and gp130 in the two groups were compared by immunohistochemical method, and the correlation between the two factors was analyzed. Results: Both SphK2 and gp130 were upregulated in the glioma group, and the two factors were significantly correlated. Conclusion: The high expression of SphK2 may play an important role in the occurrence, development, and diagnosis of glioma.

scholarly journals Preoperative assessment and preparation of patients with diseases affecting the central nervous system

2011 ◽  
Vol 58 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Branko Milakovic ◽  
Ivan Dimitrijevic ◽  
Vesna Malenkovic ◽  
Dejan Markovic ◽  
Vesna Pantic-Palibrk ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Autoregulation ◽  
Neuroprotective Effect ◽  
Preoperative Evaluation ◽  
Preoperative Assessment ◽  
Positive Pressure ◽  
Anesthetic Drugs ◽  
The Central Nervous System ◽  
Bedside Method

Purpose of review: This review will examine the most important issues of preoperative evaluation and preparation in relation to patients with deseases affecting the central nervous system. Those patients may undergo various forms of surgery unrelated to the central nervous system disease. We discuss the effect of physiologic and pharmacological factors on cerebral autoregulation and control of intracranial pressure alongside its clinical relevance with the help of new evidence. Recent findings: Regardless of the reason for surgery, coexisting diseases of brain often have important implications when selecting anesthetic drugs, procedures and monitoring techniques. Suppression of cerebral metabolic rate is not the sole mechanism for the neuroprotective effect of anaesthetic agents. There are certain general principles, but also some specific circumstances, when we are talking about optimal anesthetic procedure for a patient with coexisting brain disease. Intravenous anesthesia, such as combination of propofol and remifentanil, provides best preservation of autoregulation. Among inhaled agents isoflurane and sevoflurane appear to preserve autoregulation at all doses, whereas with other agents autoregulation is impaired in a dose-related manner. During maintenance of anesthesia the patient is ventilated by intermittent positive pressure ventilation, at intermediate hyperventilation (PaCO2 25 - 30 mmHg). Summary: Intraoperative cerebral autoregulation monitoring is an important consideration for the patients with coexisting neurological disease. Transcranial Doppler based static autoregulation measurements appears to be the most robust bedside method for this purpose.

Surgical Endovascular Neuroradiology in the 21st Century: What Lies Ahead?

Neurosurgery ◽  
2006 ◽  
Vol 59 (suppl_5) ◽  
pp. S3-48-S3-55 ◽  
Author(s):  
Charles J. Prestigiacomo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endovascular Therapy ◽  
Neck Surgery ◽  
Cerebrovascular Diseases ◽  
Endovascular Surgery ◽  
Invasive Approach ◽  
Current State ◽  
Push Forward ◽  
The Central Nervous System

Abstract FEW COULD HAVE imagined the tremendous growth of endovascular surgery over the past 40 years. Endovascular therapy has greatly enhanced the care of the patient in neurosurgery, spine surgery, and head and neck surgery. Progress in technology and techniques continue to push forward the boundaries of what is deemed “treatable,” assuming acceptable risk. This article will briefly review the current state of endovascular surgery and speculate about what its role will be in the near and far future. Endovascular therapy provides a minimally invasive approach to the central nervous system and other systems via natural and, at times, highly selective pathways. Maximizing the accessibility of these routes to highly specific regions of the central nervous system provides an elegant and minimalist approach to treating diseases of the central nervous system with almost no “footprints” of ever having accessed the region. In the future, safe, efficient and intelligent delivery systems that may enhance or alter the tissue's response may result in successful treatment of cerebrovascular diseases, as well as other diseases of the craniospinal axis. The growth of nanotechnology, metallurgy, synthetic polymers, imaging, and training will all combine to help grow the technology and the science that is surgical endovascular neuroradiology.

Neuroprotective effect of mexiletine in the central nervous system of diabetic rats

2006 ◽  
Vol 286 (1-2) ◽  
pp. 125-131 ◽  
Author(s):  
Ozkan Ates ◽  
Suleyman R. Cayli ◽  
Eyup Altinoz ◽  
Neslihan Yucel ◽  
Ayhan Kocak ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuroprotective Effect ◽  
Diabetic Rats ◽  
The Central Nervous System

scholarly journals Role of CCR2 in Inflammatory Conditions of the Central Nervous System

2014 ◽  
Vol 34 (9) ◽  
pp. 1425-1429 ◽  
Author(s):  
Hannah X Chu ◽  
Thiruma V Arumugam ◽  
Mathias Gelderblom ◽  
Tim Magnus ◽  
Grant R Drummond ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Inflammatory Diseases ◽  
Protective Effects ◽  
Cns Inflammation ◽  
Inflammatory Conditions ◽  
The Central Nervous System ◽  
Effective Development

CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.

scholarly journals Pericytes for Therapeutic Approaches to Ischemic Stroke

2021 ◽  
Vol 15 ◽  
Author(s):  
Lu Cao ◽  
Yanbo Zhou ◽  
Mengguang Chen ◽  
Li Li ◽  
Wei Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Therapeutic Target ◽  
Neurological Disorders ◽  
Neurovascular Unit ◽  
Therapeutic Approaches ◽  
Multipotent Cells ◽  
The Central Nervous System

Pericytes are perivascular multipotent cells located on capillaries. Although pericytes are discovered in the nineteenth century, recent studies have found that pericytes play an important role in maintaining the blood—brain barrier (BBB) and regulating the neurovascular system. In the neurovascular unit, pericytes perform their functions by coordinating the crosstalk between endothelial, glial, and neuronal cells. Dysfunction of pericytes can lead to a variety of diseases, including stroke and other neurological disorders. Recent studies have suggested that pericytes can serve as a therapeutic target in ischemic stroke. In this review, we first summarize the biology and functions of pericytes in the central nervous system. Then, we focus on the role of dysfunctional pericytes in the pathogenesis of ischemic stroke. Finally, we discuss new therapies for ischemic stroke based on targeting pericytes.

scholarly journals Reversible lesion of the corpus callosum associated with COVID-19: A case report

2021 ◽  
Vol 26 (4) ◽  
pp. 821-824
Author(s):  
Yagmur Inalkac Gemici ◽  
Irem Tasci
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Rare Case ◽  
Splenial Lesion ◽  
Reversible Lesion ◽  
The Central Nervous System ◽  
Reversible Splenial Lesion Syndrome

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the central nervous system and peripheral nervous system. Major central nervous system manifestations of SARS-CoV-2 infection include seizures, meningoencephalitis, ischemic stroke, anosmia, and hypogeusia. The reversible splenial lesion syndrome was first described in 2004. Although reversible splenial lesion syndrome was initially recognized as a benign phenomenon, a second type of reversible splenial lesion syndrome was identified in later years, which has a poorer prognosis and potentially serious sequela. Reversible splenial lesion syndrome can be caused by numerous etiologies including viruses. In this report, we present a rare case of COVID-19 with reversible splenial lesion, who presented with ataxia and dizziness.

scholarly journals Acute Ischemic Stroke as a Presenting Feature of COVID-19 in a Young Adult

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Alikhani A ◽  
Azad MAS ◽  
Pakzad A ◽  
Beyzaee AM
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Young Adult ◽  
Respiratory Symptoms ◽  
Respiratory Organ ◽  
The Central Nervous System ◽  
Neurological Presentation ◽  
Lung Ct ◽  
Lung Ct Scan

Introduction: Coronavirus primarily affects the respiratory organ and results in respiratory symptoms. However, this newly emergent virus is not entirely known; therefore, not all symptoms are defined yet. Several reports have shown that the virus has a tendency to infect the central nervous system. In this report, we present a patient with COVID-19 and concurrent neurological presentation who was positive for lung CT scan and positive anti-COVID-19 antibody.

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