Allergic reaction and metal hypersensitivity after shoulder joint replacement

Abstract Purpose Metal ion release may cause local and systemic effects and induce hypersensitivity reactions. The aim of our study is first to determine if implant-related hypersensitivity correlates to patient symptoms or not; second, to assess the rate of hypersensitivity and allergies in shoulder arthroplasty. Methods Forty patients with shoulder replacements performed between 2015 and 2017 were studied with minimum 2-year follow-up; no patient had prior metal implants. Each patient underwent radiographic and clinical evaluation using the Constant-Murley Score (CMS), 22 metal and cement haptens patch testing, serum and urine tests to evaluate 12 metals concentration, and a personal occupational medicine interview. Results At follow-up (average 45 ± 10.7 months), the mean CMS was 76 ± 15.9; no clinical complications or radiographic signs of loosening were detected; two nickel sulfate (5%), 1 benzoyl peroxide (2.5%) and 1 potassium dichromate (2.5%) positive findings were found, but all these patients were asymptomatic. There was an increase in serum aluminum, urinary aluminum and urinary chromium levels of 1.74, 3.40 and 1.83 times the baseline, respectively. No significant difference in metal ion concentrations were found when patients were stratified according to gender, date of surgery, type of surgery, and type of implant. Conclusions Shoulder arthroplasty is a source of metal ion release and might act as a sensitizing exposure. However, patch test positivity does not seem to correlate to hypersensitivity cutaneous manifestations or poor clinical results. Laboratory data showed small constant ion release over time, regardless of gender, type of shoulder replacement and implant used. Levels of evidence Level II.

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Mapping Tribo-Corrosion Behaviour of TI-6AL-4V Eli in Laboratory Simulated Hip Joint Environments

Lubricants ◽

10.3390/lubricants8070069 ◽

2020 ◽

Vol 8 (7) ◽

pp. 69 ◽

Cited By ~ 1

Author(s):

Ghulam Rasool ◽

Yousuf El Shafei ◽

Margaret M. Stack

Keyword(s):

Hip Joint ◽

Metal Ion ◽

Corrosion Behaviour ◽

Abrasive Particle ◽

Wear Loss ◽

Ion Release ◽

Protective Oxide ◽

Simulated Environment ◽

Metal Ion Release ◽

Significant Difference

Wear and corrosion in artificial hip replacements are known to result in metal ion release and wear debris induced osteolysis. This may lead to pain and sensitivity for patients. This infers that pre-clinical testing is critical in determining the long-term performance, safety, and reliability of the implant materials. For this purpose, micro-abrasion-corrosion tests were carried out on a biocompatible material, Ti-6Al-4V ELI, using a T-66, Plint micro-abrasion test rig in conjunction with Gill Ac corrosion testing apparatus for the range of applied loads and electrical potentials in the hip joint simulated environment. A Ringer’s solution, with and without an abrasive particle (silicon carbide), was used to enable the interactions between abrasion and corrosion. In this paper, the effects of applied load and electrochemical potential on the tribo-corrosion behaviour of Ti-6Al-4V in a bio-simulated environment are presented. The wastage, micro-abrasion-corrosion mechanisms, and synergy behaviour were identified and mapped. A significant difference in corrosion current densities was observed in the presence of abrasive particles, suggesting the removal of the protective oxide layer. The results also indicate that Ti-6Al-4V had significant abrasive wear loss when coupled with a ceramic counterpart. According to the mechanism, micro-abrasion plays a predominant role in the abrasion-corrosion behaviour of this material and the material losses by mechanical processes are substantially larger than losses, due to electrochemical processes.

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Unexpected varus deformity and concomitant metal ion release and MRI findings of modular-neck hip stems: descriptive RSA study in 75 hips with 8 years’ follow-up

Acta Orthopaedica ◽

10.1080/17453674.2020.1853387 ◽

2020 ◽

pp. 1-7

Author(s):

Sverrir Kiernan ◽

Bart Kaptein ◽

Carl Flivik ◽

Martin Sundberg ◽

Gunnar Flivik

Keyword(s):

Metal Ion ◽

Varus Deformity ◽

Mri Findings ◽

Ion Release ◽

Modular Neck ◽

Metal Ion Release ◽

Hip Stems

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Faculty Opinions recommendation of Imperfect coordination chemistry facilitates metal ion release in the Psa permease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718170860.793499535 ◽

2014 ◽

Author(s):

Ian Roberts ◽

Helen Jesse

Keyword(s):

Coordination Chemistry ◽

Metal Ion ◽

Ion Release ◽

Metal Ion Release

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Bioactive Plasma Coatings on Orthodontic Brackets: In Vitro Metal Ion Release and Cytotoxicity

Coatings ◽

10.3390/coatings11070857 ◽

2021 ◽

Vol 11 (7) ◽

pp. 857

Author(s):

Lasni Samalka Kumarasinghe ◽

Neethu Ninan ◽

Panthihage Ruvini Lakshika Dabare ◽

Alex Cavallaro ◽

Esma J. Doğramacı ◽

...

Keyword(s):

Metal Ion ◽

Prolonged Exposure ◽

Orthodontic Brackets ◽

Plasma Polymer ◽

Functional Coatings ◽

Key Factors ◽

Ion Release ◽

Metal Ion Release ◽

Surface Functionalisation

The metal ion release characteristics and biocompatibility of meta-based materials are key factors that influence their use in orthodontics. Although stainless steel-based alloys have gained much interest and use due to their mechanical properties and cost, they are prone to localised attack after prolonged exposure to the hostile oral environment. Metal ions may induce cellular toxicity at high dosages. To circumvent these issues, orthodontic brackets were coated with a functional nano-thin layer of plasma polymer and further immobilised with enantiomers of tryptophan. Analysis of the physicochemical properties confirmed the presence of functional coatings on the surface of the brackets. The quantification of metal ion release using mass spectrometry proved that plasma functionalisation could minimise metal ion release from orthodontic brackets. Furthermore, the biocompatibility of the brackets has been improved after functionalisation. These findings demonstrate that plasma polymer facilitated surface functionalisation of orthodontic brackets is a promising approach to reducing metal toxicity without impacting their bulk properties.

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A New Nanocomposite Packaging Based on LASiS-Generated AgNPs for the Preservation of Apple Juice

Antibiotics ◽

10.3390/antibiotics10070760 ◽

2021 ◽

Vol 10 (7) ◽

pp. 760

Author(s):

Maria Chiara Sportelli ◽

Antonio Ancona ◽

Annalisa Volpe ◽

Caterina Gaudiuso ◽

Valentina Lavicita ◽

...

Keyword(s):

Metal Ion ◽

Chemical Characterization ◽

Average Diameter ◽

Biological Action ◽

Metal Species ◽

Ion Release ◽

Bioactive Materials ◽

Transmission Electron ◽

Metal Ion Release ◽

Bulk Chemical

Designing bioactive materials, with controlled metal ion release, exerting a significant biological action and associated to low toxicity for humans, is nowadays one of the most important challenges for our community. The most looked-for nanoantimicrobials are capable of releasing metal species with defined kinetic profiles, either by slowing down or inhibiting bacterial growth and pathogenic microorganism diffusion. In this study, laser ablation synthesis in solution (LASiS) has been used to produce bioactive Ag-based nanocolloids, in isopropyl alcohol, which can be used as water-insoluble nano-reservoirs in composite materials like poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Infrared spectroscopy was used to evaluate the chemical state of pristine polymer and final composite material, thus providing useful information about synthesis processes, as well as storage and processing conditions. Transmission electron microscopy was exploited to study the morphology of nano-colloids, along with UV-Vis for bulk chemical characterization, highlighting the presence of spheroidal particles with average diameter around 12 nm. Electro-thermal atomic absorption spectroscopy was used to investigate metal ion release from Ag-modified products, showing a maximum release around 60 ppb, which ensures an efficient antimicrobial activity, being much lower than what recommended by health institutions. Analytical spectroscopy results were matched with bioactivity tests carried out on target microorganisms of food spoilage.

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