New research progress on the pre-Sinian tectonic evolution and neotectonics of the Huangling anticline region, South China

2012 ◽  
Vol 23 (5) ◽  
pp. 639-647 ◽  
Author(s):  
Songbai Peng ◽  
Timothy M. Kusky ◽  
Hanwen Zhou ◽  
Lu Wang ◽  
Wei Xiang
Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 1003-1011
Author(s):  
Guanyu Zhang ◽  
Yiran Li ◽  
Jiasheng Xu ◽  
Zhenfang Xiong

AbstractOsteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18–25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS.


2021 ◽  
Vol 95 (1) ◽  
pp. 77-90
Author(s):  
Zhiwen TIAN ◽  
Wu TANG ◽  
Pujun WANG ◽  
Zhigang ZHAO ◽  
Xiaomeng SUN ◽  
...  

Minerals ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 333 ◽  
Author(s):  
Wei Liu ◽  
Xiaoyong Yang ◽  
Shengyuan Shu ◽  
Lei Liu ◽  
Sihua Yuan

Zircon U–Pb dating and Hf isotopic analyses are performed on clastic rocks, sedimentary tuff of the Dongchuan Group (DCG), and a diabase, which is an intrusive body from the base of DCG in the SW Yangtze Block. The results provide new constraints on the Precambrian basement and the Late Paleoproterozoic to Mesoproterozoic tectonic evolution of the SW Yangtze Block, South China. DCG has been divided into four formations from the bottom to the top: Yinmin, Luoxue, Heishan, and Qinglongshan. The Yinmin Formation, which represents the oldest rock unit of DCG, was intruded by a diabase dyke. The oldest zircon age of the clastic rocks from the Yinmin Formation is 3654 Ma, with εHf(t) of −3.1 and a two-stage modeled age of 4081 Ma. Another zircon exhibits an age of 2406 Ma, with εHf(t) of −20.1 and a two-stage modeled age of 4152 Ma. These data provide indirect evidence for the residues of the Hadean crustal nuclei in the Yangtze Block. In combination with the published data, the ages of detrital zircons from the Yinmin Formation yielded three peak ages: 1.84, 2.30 and 2.71 Ga. The peaks of 1.84 and 2.71 Ga are global in distribution, and they are best correlated to the collisional accretion of cratons in North America. Moreover, the peak of 1.84 Ga coincides with the convergence of the global Columbia supercontinent. The youngest age of the detrital zircon from the Yinmin Formation was 1710 Ma; the age of the intrusive diabase was 1689 ± 34 Ma, whereas the weighted average age of the sedimentary tuff from the Heishan Formation was 1414 ± 25 Ma. It was presumed that the depositional age for DCG was 1.71–1.41 Ga, which was in accordance with the timing of the breakup of the Columbia supercontinent. At ~1.7 Ga, the geochemical data of the diabase were characterized by E-MORB and the region developed the same period A-type granites. Thus, 1.7 Ga should represent the time of the initial breakup of the Yangtze Block. Furthermore, the Yangtze Block continues to stretch and breakup until ~1.4 Ga, which is characterized by the emergence of oceanic island, deep-sea siliceous rock and flysch, representing the final breakup. In brief, the tectonic evolution of the Yangtze Block during the Late Paleoproterozoic to Mesoproterozoic coincided with the events caused by the convergence and breakup of the Columbia supercontinent, because of which, the Yangtze Block experienced extensive magmatic activity and sedimentary basin development during this period.


2018 ◽  
Vol 96 (2) ◽  
pp. 103-112 ◽  
Author(s):  
Chenggui Miao ◽  
Guoxue Zhang ◽  
Zhongwen Xie ◽  
Jun Chang

miRNA is a short non-coding RNA that can influence mRNA processing at the post-transcriptional level. A large number of miRNAs have been found in virtually all species so far, and these small molecules play an important role in many different physiological processes and various pathologic conditions, such as cell metabolism, cancer, autoimmune disease, and diabetes mellitus. T2D arises from a dysregulated response to the elevated glucose level in the circulation. The prevalence of T2D has increased dramatically in all age groups, and T2D in older adults is associated with more T2D complications and higher mortality. Despite the existing findings describing the pathological mechanism, T2D pathology is more complex and the pathophysiology of the disease is still not fully elucidated. In this review, we summarize the current understanding of miRNA-mediated modulation of gene expression in T2D pathogenesis, as well as related signaling pathways, and insight into the important role of miRNA in various T2D complications. Furthermore, the potential therapeutic value of miRNA for T2D patients is also discussed in detail.


1996 ◽  
Vol 101 (B7) ◽  
pp. 16137-16154 ◽  
Author(s):  
Stuart A. Gilder ◽  
James Gill ◽  
Robert S. Coe ◽  
Xixi Zhao ◽  
Zhongwei Liu ◽  
...  

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