Surface modification of titanium implants with micro–nano-topography and NIR photothermal property for treating bacterial infection and promoting osseointegration

Many techniques for the surface modification of titanium and its alloys have been proposed from the viewpoint of improving bioactivity. This paper contains an overview of surface treatment methods, including coating with hydroxyapatite (HAp), an osteoconductive compound. There are two types of coating methods: pyroprocessing and hydroprocessing. In this paper, hydroprocessing for coating on the titanium substrate with HAp, carbonate apatite (CO3–Ap), a CO3–Ap/CaCO3composite, HAp/collagen, and a HAp/gelatin composite is outlined. Moreover, evaluation by implantation of surface-modified samples in rat tibiae is described.

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Surface Modification of Titanium Dental Implants: A Review

Journal of Nepalese Prosthodontic Society ◽

10.3126/jnprossoc.v1i1.23849 ◽

2018 ◽

Vol 1 (1) ◽

pp. 38-46

Author(s):

Ujjwal Rimal ◽

S. Joshi ◽

P. Shrestha

Keyword(s):

Surface Modification ◽

Dental Implants ◽

Titanium Implant ◽

Clinical Parameter ◽

Titanium Implants ◽

Advantages And Disadvantages ◽

Roughened Surface ◽

Living Bone ◽

Modification Of Titanium ◽

Titanium Dental Implants

Osseointegration of titanium dental implants is the most important clinical parameter for an implant to be successful. One of most biocompatible material, titanium can be made to affix fast on to host bone via various modification of its surface. Machined and smooth titanium implant osseointegrate into living bone tissue but with a roughened surface, this is much more predictable as well as promising clinically. Surface modification allows for an increase in the surface area on to which the osteoblasts easily start laying bone. So, there have been various methods to roughen the surface of titanium implants. The article describes various methods used for modifying the surfaces of dental implants, giving a note on their clinical efficacy as well as advantages and disadvantages of these methods.

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Surface Modification of Titanium with Heparin-Chitosan Multilayers via Layer-by-Layer Self-Assembly Technique

Journal of Nanomaterials ◽

10.1155/2011/423686 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 19

Author(s):

Yao Shu ◽

Guomin Ou ◽

Li Wang ◽

Jingcai Zou ◽

Quanli Li

Keyword(s):

Surface Modification ◽

Self Assembly ◽

Pure Titanium ◽

Titanium Substrate ◽

Titanium Implants ◽

Layer By Layer ◽

Assembly Technique ◽

Titanium Surfaces ◽

Modification Of Titanium ◽

Positively Charged

Extracellular matrix (ECM), like biomimetic surface modification of titanium implants, is a promising method for improving its biocompatibility. In this paper chitosan (Chi) and heparin (Hep) multilayer was coated on pure titanium using a layer-by-layer (LbL) self-assembly technique. The Hep-Chi multilayer growth was carried out by first depositing a single layer of positively charged poly-L-lysine (PLL) on the NaOH-treated titanium substrate (negatively charged surface), followed by alternate deposition of negatively charged Hep and positively charged Chi, and terminated by an outermost layer of Chi. The multilayer was characterized by DR-FTIR, SEM, and AFM, and osteoblasts were cocultured with the modified titanium and untreated titanium surfaces, respectively, to evaluate their cytocompatibilityin vitro. The results confirmed that Hep-Chi multilayer was fabricated gradually on the titanium surface. The Hep-Chi multilayer-coated titanium improved the adhesion, proliferation and differentiation of osteoblasts. Thus, the approach described here may provide a basis for the preparation of modified titanium surfaces for use in dental or orthopedic implants.

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