<p>The S&#227;o Paulo Macro Metropolis (SPMM) is composed of five metropolitan regions (i.e., S&#227;o Paulo, Campinas, Para&#237;ba Valley and North Coast, Sorocaba, and Santos), two urban agglomerations (i.e., Piracicaba and Jundia&#237;) and a microregion of Bragan&#231;a. With an estimated 33 million inhabitants over an area 53,000 km<sup>2</sup>. Urban areas take up 11,000 km<sup>2</sup> of this area, represented by 174 municipalities that account for nearly 73.9% of the state&#8217;s total population. The SPMM is already experiencing the impacts of severe climate events. It is situated along a transition climatic region between humid subtropical and tropical climates. Meteorological systems such as cold fronts, the South Atlantic Convergence Zone (ZCAS), sea breezes, urban heat islands, and other local circulations associated with topography favor the occurrence of severe weather at different time scales. The study aims at understanding climate change effects on the intensity and frequency of temperature and precipitation extremes in the SPMM, contributing to the establishment of policies to reduce the existing socioenvironmental risks in urban areas. For this, the ability of observation systems, reanalysis (ERA5, ERA40, NCEP/NCAR, and Terra Climate), and remote sensing (CMAP and CPC) were analyzed and used to show the decadal evolution of extreme events in SPMM. We also investigated the potential of CMIP5 models to simulate the extreme precipitation and temperature events in the SPMM that occurred between the 1950s and 2005. Future climate changes in the SPMM were analyzed based on CMIP5 models that best simulate past extreme events in the SPMM, considering the different carbon emission scenarios. This study is important to develop adaptive strategies to deal with climate change impacts on urban areas, such as droughts and floods.</p>