scholarly journals Green and Non‐conventional Extraction of Bioactive Compounds from Olive Leaves: Screening of Novel Natural Deep Eutectic Solvents and Investigation of Process Parameters

2021 ◽  
Author(s):  
Ayşe Ezgi Ünlü
Keyword(s):  
Bioactive Compounds ◽  
Process Parameters ◽  
Deep Eutectic Solvents ◽  
Olive Leaves ◽  
Natural Deep Eutectic Solvents ◽  
Conventional Extraction

scholarly journals Effects of Ultrasound-Assisted Extraction and Solvent on the Phenolic Profile, Bacterial Growth, and Anti-Inflammatory/Antioxidant Activities of Mediterranean Olive and Fig Leaves Extracts

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1718 ◽  
Author(s):  
Cristina Alcántara ◽  
Tihana Žugčić ◽  
Radhia Abdelkebir ◽  
Jose V. García-Pérez ◽  
Anet Režek Jambrak ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Bacterial Growth ◽  
Extraction Methods ◽  
Olive Leaves ◽  
Ultrasound Assisted Extraction ◽  
Phenolic Profile ◽  
Assisted Extraction ◽  
Ultrasound Assisted ◽  
Conventional Extraction ◽  
Anti Inflammatory

Mediterranean plants, such as fig and olive leaves, are well-known to exert beneficial effects in humans because of the presence of a wide range of bioactive compounds. However, scarce information regarding the impact of extraction methods, such as ultrasound and types of solvents, on their profile of antioxidant and anti-inflammatory compounds is provided. In addition, no information is available on the effects of extraction methods and solvents on the inhibition of pathogenic bacteria or promoting probiotic growth. In this scenario, this study was aimed to study the effects of ultrasound-assisted extraction (UAE) and solvent on the phenolic profile (Triple TOF-LC-MS/MS), antioxidant and anti-inflammatory compounds of olive and fig leaves. Results showed that UAE extracted more carotenoids compared to conventional extraction, while the conventional extraction impacted on higher flavonoids (olive leaves) and total phenolics (fig leaves). The antioxidant capacity of aqueous extract of fig leaves was three times higher than the extract obtained with ethanol for conventional extraction and four times higher for UAE. In general terms, hydroethanolic extracts presented the highest bacterial growth inhibition, and showed the highest anti-inflammatory activity. In conclusion, these side streams can be used as sources of bioactive compounds for further development of high-added-value products.

scholarly journals Deep Eutectic Solvents for the Extraction of Bioactive Compounds from Natural Sources and Agricultural By-Products

2021 ◽  
Vol 11 (11) ◽  
pp. 4897
Author(s):  
Bárbara Socas-Rodríguez ◽  
M. Vanessa Torres-Cornejo ◽  
Gerardo Álvarez-Rivera ◽  
Jose A. Mendiola
Keyword(s):  
Bioactive Compounds ◽  
Deep Eutectic Solvents ◽  
Extraction Methods ◽  
In Vitro Cytotoxicity ◽  
In Vivo Studies ◽  
Natural Sources ◽  
Natural Deep Eutectic Solvents ◽  
By Products

In this work, a review about the applicability of eutectic solvents, mainly deep eutectic solvents (DES) and natural deep eutectic solvents (NADES), for the extraction of bioactive compounds from natural products has been carried out. These alternative solvents have shown not only to have high extraction yields but also to be environmentally friendly, exhibiting very low or almost no toxicity, compared to conventional organic solvents. The last trends and main extraction methods that have been most widely used in studies using these emerging solvents have been reviewed, as well as the varied natural sources in which they have been used, including agro-food by-products. Besides the toxicity, biodegradability of these solvents is reviewed. Likewise, different reported bioactivity tests have been included, in which extracts obtained with these ecological solvents have been tested from antioxidant activity analysis to in vivo studies with rats, through in vitro cytotoxicity tests.

scholarly journals Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Plants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1428 ◽  
Author(s):  
Milena Ivanović ◽  
Maša Islamčević Razboršek ◽  
Mitja Kolar
Keyword(s):  
Bioactive Compounds ◽  
Analytical Methods ◽  
Plant Material ◽  
Deep Eutectic Solvents ◽  
Original Research ◽  
Extraction Techniques ◽  
Plant Metabolites ◽  
Plant Materials ◽  
Isolation And Characterization ◽  
Natural Deep Eutectic Solvents

The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

scholarly journals Mass transfer intensification in bioactive compounds recovery by alternative extraction methods: effects of solvent

2018 ◽  
Vol 21 (1) ◽  
pp. 30-36
Keyword(s):  
Bioactive Compounds ◽  
Choline Chloride ◽  
Low Frequency ◽  
Deep Eutectic Solvents ◽  
Solvent System ◽  
Extraction Methods ◽  
Ultrasound Assisted Extraction ◽  
Power Intensity ◽  
Natural Deep Eutectic Solvents ◽  
Pre Treatment

<p>Recently, the exploration of new alternatives to common organic solvents in combination with non-conventional energy sources is a subject of intense research and development as tools for green extraction of plant-derived natural products. This paper deals with the use of low frequency ultrasound (100 W, 32 kHz) and pulsed electrical fields (0.86 kV cm-1, 13 Hz) to raise the efficiency of the extraction of selected plant species rich in valuable phenolic compounds.Four types of natural deep eutectic solvents were applied for the ultrasound-assisted extraction of silymarin from milk thistle among which a choline-chloride-based mixture with glycerol was proved to be the most promising one. Additionally, the usage of high ultrasound power significantly increased the concentration of sylimarin as compared to traditional ethanol extraction, generating rapidly for 10 min considerable temperature rise as a side effect under non-cooling conditions. The application of PEF as a pre-treatment for 0.8 s to the extraction allowed reducing the ethanol percentage in the ethanol/water mixtures giving comparable phenolic yields, without any, or very little, increase in temperature. As such, optimized power intensity in conjunction with appropriate solvent system provides a potential to improve the release of thermally unstable bioactive compounds under mild processing conditions.</p>

A review of sustainable lignocellulose biorefining applying (natural) deep eutectic solvents (DESs) for separations, catalysis and enzymatic biotransformation processes

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ana Bjelić ◽  
Brigita Hočevar ◽  
Miha Grilc ◽  
Uroš Novak ◽  
Blaž Likozar
Keyword(s):  
Special Section ◽  
Cost Effective ◽  
Deep Eutectic Solvents ◽  
Reaction Conditions ◽  
Co Catalysts ◽  
Biomass Fractionation ◽  
Functional Step ◽  
Natural Deep Eutectic Solvents ◽  
Economic Need ◽  
Molecular Compounds

AbstractConventional biorefinery processes are complex, engineered and energy-intensive, where biomass fractionation, a key functional step for the production of biomass-derived chemical substances, demands industrial organic solvents and harsh, environmentally harmful reaction conditions. There is a timely, clear and unmet economic need for a systematic, robust and affordable conversion method technology to become greener, sustainable and cost-effective. In this perspective, deep eutectic solvents (DESs) have been envisaged as the most advanced novel polar liquids that are entirely made of natural, molecular compounds that are capable of an association via hydrogen bonding interactions. DES has quickly emerged in various application functions thanks to a formulations’ simple preparation. These molecules themselves are biobased, renewable, biodegradable and eco-friendly. The present experimental review is providing the state of the art topical overview of trends regarding the employment of DESs in investigated biorefinery-related techniques. This review covers DESs for lignocellulosic component isolation, applications as (co)catalysts and their functionality range in biocatalysis. Furthermore, a special section of the DESs recyclability is included. For DESs to unlock numerous new (reactive) possibilities in future biorefineries, the critical estimation of its complexity in the reaction, separation, or fractionation medium should be addressed more in future studies.

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