1α,25-Dihydroxyvitamin D3 Modulates CYP2R1 Gene Expression in Human Oral Squamous Cell Carcinoma Tumor Cells

2014 ◽  
Vol 5 (2) ◽  
pp. 90-97 ◽  
Author(s):  
Kumaran Sundaram ◽  
Yuvaraj Sambandam ◽  
Eichi Tsuruga ◽  
Carol L. Wagner ◽  
Sakamuri V. Reddy
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Dihydroxyvitamin D3 ◽  
Squamous Cell Carcinoma Tumor ◽  
Carcinoma Tumor

scholarly journals RANK Ligand Modulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells

2015 ◽  
Vol 117 (1) ◽  
pp. 118-125 ◽  
Author(s):  
Yuvaraj Sambandam ◽  
Sashank Sakamuri ◽  
Sundaravadivel Balasubramanian ◽  
Azizul Haque
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Rank Ligand ◽  
Squamous Cell Carcinoma Tumor ◽  
Carcinoma Tumor

scholarly journals Autoregulation of RANK ligand in oral squamous cell carcinoma tumor cells

2018 ◽  
Vol 233 (8) ◽  
pp. 6125-6134 ◽  
Author(s):  
Yuvaraj Sambandam ◽  
Purushoth Ethiraj ◽  
Jessica D. Hathaway-Schrader ◽  
Chad M. Novince ◽  
Ezhil Panneerselvam ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Rank Ligand ◽  
Squamous Cell Carcinoma Tumor ◽  
Carcinoma Tumor

scholarly journals Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells

Oncotarget ◽  
2015 ◽  
Vol 6 (25) ◽  
pp. 20902-20920 ◽  
Author(s):  
Joao Paulo Oliveira-Costa ◽  
Alex Fiorini de Carvalho ◽  
Giorgia Gobbi da Silveira ◽  
Peter Amaya ◽  
Yongqi Wu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Expression Patterns ◽  
Gene Expression Patterns

Head and Neck Squamous cell Carcinoma Targeted Chemosensitization

2009 ◽  
Vol 141 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Mindy R. Figures ◽  
Jessie Wobb ◽  
Koji Araki ◽  
Tingyan Liu ◽  
Lei Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Squamous Cell Carcinoma Tumor ◽  
Carcinoma Tumor

OBJECTIVE: The current treatment for advanced head and neck squamous cell carcinoma continues to result in poor outcomes. The purpose of this study is to investigate the benefit of fibroblast growth factor 2-targeted adenovirus-mediated mutant-Rad50 (FGF2-Ad-Rad50) gene transfer in enhancing chemosensitization for head and neck squamous cell carcinoma and reducing chemotoxicity. STUDY DESIGN: Randomized controlled laboratory study. SETTING: University of Pennsylvania, Philadelphia, PA. SUBJECTS AND METHODS: Human head and neck squamous cell carcinoma tumor cells and a mouse model with human head and neck squamous cell carcinoma were used for this study. There were five mice in each study group. FGF2-fab' molecule was conjugated with an adenoviral mutant-Rad50 construct. FGF2-targeted transgene expression efficiency was evaluated in vitro. Tumor cytotoxicity and growth inhibition were examined after combined FGF2-Ad-Rad50 with cisplatin treatment in vitro and in vivo. Anti-tumor mechanisms were investigated. RESULTS: FGF2-targeted gene transfer approach significantly improved transgene expression in head and neck squamous cell carcinoma tumor cells over a nontargeted approach (207.51 ± 33.62 vs 51.44 ± 8.28, respectively). FGF2-Ad-Rad50 with cisplatin demonstrated a superior tumor suppression effect (264.5 ± 124.1 mm 3 vs 567.1 ± 267.6 mm 3 ), increased DNA double-strand breaks (1349 ± 51.67 vs 774 ± 28.56), and anti-angiogenesis (%ROI: 0.76% ± 0.38% vs 2.10% ± 1.66%) in tumor cells over nontargeted adenovirus. CONCLUSION: Combination of FGF2-Ad-Rad50 with cisplatin significantly improves anti-tumor effect by targeting DNA repair systems and tumor angiogenesis. The great benefit of this strategy supports clinical trial for novel treatment of head and neck squamous cell carcinoma.

Effect of a diffractive grid applied to laryngeal images with squamous cell carcinoma tumor

2021 ◽  
Author(s):  
Jacilene Martins Medeiros ◽  
Giuseppe Antônio Cirino ◽  
Arlindo Neto Montagnoli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinoma Tumor ◽  
Carcinoma Tumor
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