scholarly journals Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

2017 ◽  
Vol 7 (8) ◽  
pp. 793-802 ◽  
Author(s):  
M. Naz ◽  
N. Nasiri ◽  
M. Ikram ◽  
M. Nafees ◽  
M. Z. Qureshi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Drug ◽  
Ag Nanoparticles ◽  
Cytotoxic Effect ◽  
Drug Loading

Evaluation of infrared thermography combined with drug-loaded superparamagnetic nanoparticles for the diagnosis and treatment of breast cancer

2021 ◽  
Vol 11 (1) ◽  
pp. 9-15
Author(s):  
Cunguo Yu ◽  
Lixin Zhang ◽  
Jinying Liu ◽  
Xiaoguang Wang
Keyword(s):  
Breast Cancer ◽  
Anticancer Drug ◽  
Thermal Imaging ◽  
Drug Loading ◽  
Integrated Approach ◽  
Superparamagnetic Nanoparticles ◽  
Diagnosis And Treatment ◽  
Physical And Mental Health ◽  
Infrared Thermal Imaging ◽  
Prompt Diagnosis

Breast cancer (BC) is a common malignant tumor that threatens both the physical and mental health of women worldwide, the incidence of BC is increasing each year. Early detection and prompt diagnosis are key for prevention of BC and will promote reductions in morbidity and mortality. As such, we present here an integrated diagnostic and treatment strategy for BC that is based on infrared thermal imaging (IRTI) combined with superparamagnetic iron tetroxide (Fe3O4) nanoparticles. In this work, a doxorubicin (DOX) anticancer drug platform was generated using polyethylene-coated paramagnetic nano-iron tetroxide particles, and IRTI technology was used to implement an integrated approach to diagnosis and treatment. The therapeutic efficacy of the DOX anticancer drug system utilizing nano-iron tetroxide superparamagnetic particles was examined. DOX anticancer drug composite nanomaterials based on superparamagnetic Fe3O4 nanoparticles (PEG-Fe3O4@DOX). The size distribution of NPs was 14.5 ± 0.53 nm, and the drug encapsulation rate (80.1%) and drug loading rate (35.3%) were higher PEG-Fe3O4@DOX. The results showed that the acidic medium was beneficial to the release of DOX PEG-Fe3O4@DOX. It is beneficial to release DOX from NPs PEG-Fe3O4@DOX NPs can accurately reach the cancerous site for release and achieve the purpose of precise treatment.

scholarly journals CYTOTOXIC EFFECT OF PEPTIDE FUNCTIONALIZED SILVER NANOPARTICLES SYNTHESIZED FROM ALOIN ON BREAST CANCER CELL LINE

2019 ◽  
pp. 170-175
Author(s):  
LEEMA ROSE A ◽  
VIDHYA S ◽  
JANEETA PRIYA F ◽  
SABEENA ASHIFA J
Keyword(s):  
Breast Cancer ◽  
Silver Nanoparticles ◽  
Zeta Potential ◽  
Cell Line ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Ag Nanoparticles ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Uv Visible

Objective: The aim of the present study is to synthesize the silver (Ag) nanoparticle using Aloin with a focus on its antibacterial, antioxidant, and anticancer activity. Methods: The silver nanoparticles were synthesized using Aloin and were determined by UV-Visible spectrum. It was further characterized by scanning electron microscope (SEM), zeta potential, and dynamic light scattering (DLS). The Fourier transform infrared analysis was also carried out for the Aloin. Results: The UV-Visible absorption spectrum of the synthesized silver nanoparticles has shown the absorption peak at 439nm which proves the formation of silver nanoparticles in the solution. The SEM analysis revealed that the Ag nanoparticles were spherical in shape. The IR spectra showed that there are 6 functional groups are present in Aloin extract. The synthesized nanoparticles are found to be highly stable with an average particle size of 130.7nm which was confirmed by zeta potential and DLS analysis. The synthesized nanoparticles had a good antibacterial and antioxidant activity. It shows a very good cytotoxic effect against breast cancer cell line. Conclusion: The present study suggests that the synthesis route is free from the requirements such as high energy, extended preparation time, and special equipments and thus can be used for large-scale synthesis in food industries for food preservation and these Ag nanoparticles can be used for its therapeutic purposes for developing a new drug against cancer.

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

scholarly journals Co-delivery of 5-fluorodeoxyuridine and doxorubicin via gold nanoparticle equipped with affibody-DNA hybrid strands for targeted synergistic chemotherapy of HER2 overexpressing breast cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Chao Zhang ◽  
Fanghua Zhang ◽  
Mengnan Han ◽  
Xuming Wang ◽  
Jie Du ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Solid Phase ◽  
Clinical Care ◽  
Drug Loading ◽  
Her2 Positive ◽  
Apoptosis Pathway ◽  
Phase Synthesis ◽  
Drug Nanocarriers ◽  
Dual Drug

AbstractCombination chemotherapy is still of great importance as part of the standard clinical care for patients with HER2 positive breast cancer. As an attractive component, gold nanoparticles (AuNPs) have been extensively studied as biosafety nanomaterials, but they are rarely explored as drug nanocarriers for targeted co-delivery of multiple chemotherapeutics. Herein, a novel affibody-DNA hybrid strands modified AuNPs were fabricated for co-loading nucleoside analogue (5-fluorodeoxyuridine, FUdR) and anthracycline (doxorubicin, Dox). FUdRs were integrated into DNA hybrid strands decorated on AuNPs by DNA solid phase synthesis, and Dox molecules were intercalated into their duplex regions. Affibody molecules coupled to the DNA hybrid strands were distributed the surface of AuNPs, giving them targeting for HER2. The new dual-drug-containing affibody-DNA-AuNPs (Dox@affi-F/AuNPs) owned compact and stable spherical nanostructures, and precise drug loading. Cytotoxicity tests demonstrated that these nanoparticles caused a higher inhibition in HER2 overexpressing breast cancer cells, and showed better synergistic antitumor activity than simple mixture of the two drugs. The related mechanistic studies proved that Dox@affi-F/AuNPs achieved a remarkable combined antitumor activity of Dox and FUdR by promoting more cells to enter apoptosis pathway. Our work provided a nanomedicine platform for targeted co-delivery of nucleoside analog therapeutics and anthracycline anticancer drugs to achieve synergistic treatment of HER2+ cancer.

Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells

2012 ◽  
Vol 97 (3) ◽  
pp. 1269-1278 ◽  
Author(s):  
Chu-I Lee ◽  
Chun-Lin Lee ◽  
Jyi-Faa Hwang ◽  
Yi-Hsin Lee ◽  
Jyh-Jye Wang
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Red Mold Rice

DFT calculations of electronic structure evaluation and intermolecular interactions of p53-derived peptides with cytotoxic effect on breast cancer

2021 ◽  
Vol 140 (8) ◽  
Author(s):  
Carolina Barrientos-Salcedo ◽  
Maricarmen Lara-Rodríguez ◽  
Linda Campos-Fernández ◽  
Martha Legorreta-Herrera ◽  
Isabel Soto-Cruz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Electronic Structure ◽  
Dft Calculations ◽  
Intermolecular Interactions ◽  
Cytotoxic Effect ◽  
Structure Evaluation

ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells

2012 ◽  
Vol 315 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Till Krech ◽  
Elisa Scheuerer ◽  
Robert Geffers ◽  
Hans Kreipe ◽  
Ulrich Lehmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Breast Cancer Cells ◽  
Drug Resistant ◽  
Lobular Breast Cancer ◽  
Resistant Phenotype ◽  
Drug Resistant Phenotype

scholarly journals Corrigendum to “Cytotoxic Effect of Ethanol Extract of Microalga, Chaetoceros calcitrans, and Its Mechanisms in Inducing Apoptosis in Human Breast Cancer Cell Line”

2016 ◽  
Vol 2016 ◽  
pp. 1-1 ◽  
Author(s):  
Siyamak Ebrahimi Nigjeh ◽  
Fatimah Md Yusoff ◽  
Noorjahan Banu Mohamed Alitheen ◽  
Mehdi R. Pirozyan ◽  
Yeap Swee Keong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Ethanol Extract ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Chaetoceros Calcitrans
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