Involvement of ERK1/2/NF-κB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620

Tumor Biology ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 921-930 ◽  
Author(s):  
Donglin Guo ◽  
Hong Zhou ◽  
Ying Wu ◽  
Fang Zhou ◽  
Guoying Xu ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Colon Cancer ◽  
Cancer Cell ◽  
Signal Transduction Pathway ◽  
Colon Cancer Cell ◽  
Transduction Pathway ◽  
And Migration ◽  
Proliferation And Migration

Thymosin beta 4 induces colon cancer cell migration and clinical metastasis via enhancing ILK/IQGAP1/Rac1 signal transduction pathway

2011 ◽  
Vol 308 (2) ◽  
pp. 162-171 ◽  
Author(s):  
Mei-Chuan Tang ◽  
Li-Chuan Chan ◽  
Yi-Chen Yeh ◽  
Cheng-Yu Chen ◽  
Teh-Ying Chou ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Signal Transduction Pathway ◽  
Colon Cancer Cell ◽  
Cancer Cell Migration ◽  
Transduction Pathway ◽  
Thymosin Beta 4

scholarly journals The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Abril Sánchez-Botet ◽  
Laura Gasa ◽  
Eva Quandt ◽  
Sara Hernández-Ortega ◽  
Javier Jiménez ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration

2020 ◽  
Vol 401 (9) ◽  
pp. 1031-1039
Author(s):  
Mengmeng Ren ◽  
Xin Yang ◽  
Juntao Bie ◽  
Zhe Wang ◽  
Minghui Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Enzymatic Activity ◽  
Cancer Cell ◽  
Citrate Synthase ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

AbstractCitrate synthase (CS), the rate-limiting enzyme in the tricarboxylic acid (TCA) cycle catalyzes the first step of the cycle, namely, the condensation of oxaloacetate and acetyl-CoA to produce citrate. The expression and enzymatic activity of CS are altered in cancers, but posttranslational modification (PTM) of CS and its regulation in tumorigenesis remain largely obscure. SIRT5 belongs to the nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase sirtuin family and plays vital roles in multiple biological processes via modulating various substrates. Here, we show that SIRT5 interacts with CS and that SIRT5 desuccinylates CS at the evolutionarily conserved residues K393 and K395. Moreover, hypersuccinylation of CS at K393 and K395 dramatically reduces its enzymatic activity and suppresses colon cancer cell proliferation and migration. These results provide experimental evidence in support of a potential therapeutic approach for colon cancer.

scholarly journals LncRNA NKILA suppresses colon cancer cell proliferation and migration by inactivating PI3K/Akt pathway

2018 ◽  
Vol 7 (6) ◽  
pp. 1431-1438 ◽  
Author(s):  
Jian Huang ◽  
Lingfeng Zhao ◽  
Wei Chen ◽  
Jian Duan ◽  
Dibesh Shrestha ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Akt Pathway ◽  
Cancer Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration
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