Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case–control studies

Tumor Biology ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 3323-3330 ◽  
Author(s):  
Wen Feng Yan ◽  
Pei Chun Sun ◽  
Chang Fu Nie ◽  
Gang Wu
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Case Control ◽  
Cyclooxygenase 2 ◽  
Case Control Studies

scholarly journals ASSOCIATION OF IL-8 -251T>A (RS4073) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS BASED ON 33 CASE-CONTROL STUDIES

2020 ◽  
Vol 57 (1) ◽  
pp. 91-99
Author(s):  
Mansour MOGHIMI ◽  
Seyed Alireza DASTGHEIB ◽  
Naeimeh HEIRANIZADEH ◽  
Mohammad ZARE ◽  
Elnaz SHEIKHPOUR ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Case Control ◽  
Case Control Studies ◽  
Effect Model ◽  
Increased Risk ◽  
Mixed Populations ◽  
Stratified Analysis

ABSTRACT BACKGROUND: The role of -251A>T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene in gastric cancer was intensively evaluated, but the results of these studies were inconsistent. OBJECTIVE: Therefore, we performed a meta-analysis to provide a comprehensive data on the association of IL-8 -251T>A polymorphism with gastric cancer. METHODS: All eligible studies were identified in PubMed, Web of Science, EMBASE, Wanfang and CNKI databases before September 01, 2019. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. RESULTS: A total of 33 case-control studies with 6,192 cases and 9,567 controls were selected. Overall, pooled data showed that IL-8 -251T>A polymorphism was significantly associated with an increased risk of gastric cancer under all five genetic models, i.e., allele (A vs T: OR=1.189, 95% CI 1.027-1.378, P=0.021), homozygote (AA vs TT: OR=1.307, 95% CI 1.111-1.536, P=0.001), heterozygote (AT vs TT: OR=1.188, 95% CI 1.061-1.330, P=0.003), dominant (AA+AT vs TT: OR=1.337, 95% CI 1.115-1.602, P=0.002) and recessive (AA vs AT+TT: OR=1.241, 95% CI 1.045-1.474, P=0.014). The stratified analysis by ethnicity revealed an increased risk of gastric cancer in Asians and mixed populations, but not in Caucasians. Moreover, stratified by country found a significant association in Chinese, Korean and Brazilian, but not among Japanese. CONCLUSION: This meta-analysis suggests that the IL-8 -251T>A polymorphism is associated with an increased risk of gastric cancer, especially by ethnicity (Asian and mixed populations) and country (Chinese, Korean and Brazilian).

scholarly journals Association between green tea intake and risk of gastric cancer: a systematic review and dose–response meta-analysis of observational studies

2017 ◽  
Vol 20 (17) ◽  
pp. 3183-3192 ◽  
Author(s):  
Yanhong Huang ◽  
Hongru Chen ◽  
Liang Zhou ◽  
Gaoming Li ◽  
Dali Yi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
High Temperature ◽  
Relative Risk ◽  
Green Tea ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

AbstractObjectiveTo examine and quantify the potential dose–response relationship between green tea intake and the risk of gastric cancer.DesignWe searched PubMed, EMBASE, Web of Science, CBM, CNKI and VIP up to December 2015 without language restrictions.SettingA systematic review and dose–response meta-analysis of observational studies.SubjectsFive cohort studies and eight case–control studies.ResultsCompared with the lowest level of green tea intake, the pooled relative risk (95 % CI) of gastric cancer was 1·05 (0·90, 1·21, I2=20·3 %) for the cohort studies and the pooled OR (95 % CI) was 0·84 (0·74, 0·95, I2=48·3 %) for the case–control studies. The pooled relative risk of gastric cancer was 0·79 (0·63, 0·97, I2=63·8 %) for intake of 6 cups green tea/d, 0·59 (0·42, 0·82, I2=1·0 %) for 25 years of green tea intake and 7·60 (1·67, 34·60, I2=86·5 %) for drinking very hot green tea.ConclusionsDrinking green tea has a certain preventive effect on reducing the risk of gastric cancer, particularly for long-term and high-dose consumption. Drinking too high-temperature green tea may increase the risk of gastric cancer, but it is still unclear whether high-temperature green tea is a risk factor for gastric cancer. Further studies should be performed to obtain more detailed results, including other gastric cancer risk factors such as smoking and alcohol consumption and the dose of the effective components in green tea, to provide more reliable evidence-based medical references for the relationship between green tea and gastric cancer.

GSTM1 null genotype is associated with increased risk of gastric cancer in both ever-smokers and non-smokers: a meta-analysis of case–control studies

Tumor Biology ◽  
2013 ◽  
Vol 35 (4) ◽  
pp. 3439-3445 ◽  
Author(s):  
Jianchun Gu ◽  
Hanqing Zou ◽  
Leizhen Zheng ◽  
Xiaoping Li ◽  
Siyu Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Case Control ◽  
Gstm1 Null Genotype ◽  
Case Control Studies ◽  
Increased Risk

scholarly journals XPD Lys751Gln and Asp312Asn Polymorphisms and Gastric Cancer Susceptibility: A Meta-analysis of Case-control Studies

2013 ◽  
Vol 14 (1) ◽  
pp. 231-236 ◽  
Author(s):  
Qing-Hua Yin ◽  
Chuan Liu ◽  
Jian-Bing Hu ◽  
Rong-Rong Meng ◽  
Lian Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Effect of Red, Processed, and White Meat Consumption on the Risk of Gastric Cancer: An Overall and Dose–Response Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 826 ◽  
Author(s):  
Kim ◽  
Kim ◽  
Lee ◽  
Kwon ◽  
Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Meat Consumption ◽  
Case Control ◽  
Processed Meat ◽  
Gastric Cancer Risk ◽  
Case Control Studies ◽  
White Meat

: Whether the risk of gastric cancer varies by the types of meat consumption still remains disputable. The purpose of this meta-analysis was to identify the exact associations that red, processed, and white meat have with gastric cancer. We searched relevant studies in Medline, EMBASE, and the Cochrane Library before November 2018, including cohort and case-control studies. We used random-effect models to estimate the adjusted relative risk (RR), and Egger’s tests to evaluate publication bias. Through stepwise screening, 43 studies were included in this analysis (11 cohort studies and 32 case-control studies with 16,572 cases). In a meta-analysis for the highest versus lowest categories of meat consumption, both red (RR: 1.41, 95% confidence interval (CI): 1.21–1.66) and processed (RR: 1.57, 95% CI: 1.37–1.81) meat consumption were positively associated with gastric cancer risk, while white meat consumption was negatively associated with gastric cancer risk (RR: 0.80, 95% CI: 0.69–0.92). In a dose–response meta-analysis, the RRs of gastric cancer were 1.26 (95% CI: 1.11–1.42) for every 100 g/day increment in red meat consumption, 1.72 (95% CI: 1.36–2.18) for every 50 g/day increment in processed meat consumption, and 0.86 (95% CI: 0.64–1.15) for every 100 g/day increment in white meat consumption. The increase of white meat consumption may reduce the risk of gastric cancer, while red or processed meat may increase the risk of gastric cancer. Further studies are required to identify these associations, especially between white meat and gastric cancer.

Smoking Status and Gastric Cancer Risk: An Updated Meta-Analysis of Case-Control Studies Published in the past Ten Years

2009 ◽  
Vol 95 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Giuseppe La Torre ◽  
Giacomina Chiaradia ◽  
Francesco Gianfagna ◽  
Angelo De Lauretis ◽  
Stefania Boccia ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Smoking Status ◽  
Meta Analysis ◽  
Case Control ◽  
Gastric Cancer Risk ◽  
Case Control Studies ◽  
The Past

scholarly journals Effect of statins on gastric cancer incidence: A meta-Analysis of case control studies

2014 ◽  
Vol 10 (4) ◽  
pp. 859 ◽  
Author(s):  
Wenjin Wang ◽  
Guoyin Jin ◽  
Pei Chu ◽  
Haitao Li ◽  
Zhiyuan Ma
Keyword(s):  
Gastric Cancer ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

scholarly journals Association of Dietary Cholesterol Intake With Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
Vol 8 ◽  
Author(s):  
Peng Miao ◽  
Lin Guan
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Dietary Cholesterol ◽  
Case Control ◽  
The Body ◽  
Case Control Studies ◽  
Cholesterol Intake

Background: Many case–control studies have investigated the association between dietary cholesterol and gastric cancer, yielding inconsistent findings. We carried out a systematic review and meta-analysis of observational studies to assess the relationship between dietary cholesterol intake and gastric cancer among adults.Methods: PubMed, Scopus, and Google Scholar were systematically searched to identify articles that evaluated the association of dietary cholesterol with gastric cancer up to May 2021. Pooled odds ratio (ORs) and 95% confidence intervals (CIs) were computed using random-effects models. Dose–response analysis was used to explore the shape and strength of the association.Results: Fourteen case–control studies with 6,490 gastric cancer patients and 17,793 controls met our inclusion criteria. In the meta-analysis of the highest vs. the lowest dietary cholesterol categories, a significantly higher (~35%) risk of gastric cancer was observed in association with high cholesterol consumption (pooled OR: 1.35, 95% CI: 1.29–1.62, I2 = 68%; 95%CI: 45–81%). Subgroup analysis also showed this positive relationship in population-based case–control studies, those conducted on non-US countries, those with a higher number of cases and high-quality studies, those that collected dietary data via interviews, studies not adjusted for Helicobacter pylori infection, and studies where the body mass index was controlled. Besides, a non-linear dose–response association was also identified (P = 0.03).Conclusion: This study demonstrated that dietary cholesterol intake could significantly augment the risk of gastric cancer in case–control studies. Prospective cohort studies with large sample sizes and long durations of follow-up are required to verify our results.

scholarly journals Coffee and gastric cancer: systematic review and meta-analysis

2006 ◽  
Vol 22 (5) ◽  
pp. 889-900 ◽  
Author(s):  
Francisco Botelho ◽  
Nuno Lunet ◽  
Henrique Barros
Keyword(s):  
Gastric Cancer ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Population Based ◽  
Case Control ◽  
Cancer Knowledge ◽  
Case Control Studies ◽  
The Usa ◽  
Japanese Studies

We systematically reviewed the literature on the association between coffee consumption and gastric cancer and performed a meta-analysis of the results. Published cohort and case-control studies were identified in PubMed and reference lists. Random effects meta-analysis was used to pool effects from 23 studies, and heterogeneity was explored by stratification and meta-regression. The odds ratio (OR) for the overall association between coffee and gastric cancer (highest vs. lowest category of exposure) was 0.97 (95%CI: 0.86-1.09), similar for cohort (OR = 1.02; 95%CI: 0.76-1.37) and case-control studies (population-based: OR = 0.90; 95%CI: 0.70-1.15; hospital-based: OR = 0.97; 95%CI: 0.83-1.13). The OR was 1.26 (95%CI: 1.02-1.57) when considering five studies conducted in the USA, 0.97 (95%CI: 0.82-1.14) for the five Japanese studies, 0.98 (95%CI: 0.81-1.17) for the six studies from Europe, and 0.64 (95%CI: 0.47-0.86) for the two studies from South America. In this meta-analysis we found no adverse effect of coffee associated with gastric cancer. Knowledge on the level of exposure to different coffee constituents may provide a deeper understanding of this reassuring result and the real role of coffee on cancer risk.

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