Application of central composite design for electrochemical oxidation of reactive dye on Ti/MWCNT electrode

2019 ◽  
Vol 17 (5) ◽  
pp. 1073-1085
Author(s):  
Farideh Nabizadeh Chianeh ◽  
Mohammad Sadegh Avestan
Keyword(s):  
Central Composite Design ◽  
Electrochemical Oxidation ◽  
Reactive Dye ◽  
Central Composite

Application of the central composite design for condition optimization for semi-aerobic landfill leachate treatment using electrochemical oxidation

2010 ◽  
Vol 61 (5) ◽  
pp. 1257-1266 ◽  
Author(s):  
Soraya Mohajeri ◽  
Hamidi Abdul Aziz ◽  
Mohamed Hasnain Isa ◽  
Mohammad Ali Zahed ◽  
Mohammed J. K. Bashir ◽  
...  
Keyword(s):  
Reaction Time ◽  
Central Composite Design ◽  
Electrochemical Oxidation ◽  
Current Density ◽  
Landfill Leachate ◽  
Electrolyte Concentration ◽  
Process Conditions ◽  
Leachate Treatment ◽  
Condition Optimization ◽  
Central Composite

In the present study, Electrochemical Oxidation was used to remove COD and color from semi-aerobic landfill leachate collected from Pulau Burung Landfill Site (PBLS), Penang, Malaysia. Experiments were conducted in a batch laboratory-scale system in the presence of NaCl as electrolyte and aluminum electrodes. Central composite design (CCD) under Response surface methodology (RSM) was applied to optimize the electrochemical oxidation process conditions using chemical oxygen demand (COD) and color removals as responses, and the electrolyte concentrations, current density and reaction time as control factors. Analysis of variance (ANOVA) showed good coefficient of determination (R2) values of >0.98, thus ensuring satisfactory fitting of the second-order regression model with the experimental data. In un-optimized condition, maximum removals for COD (48.77%) and color (58.21%) were achieved at current density 80 mA/cm2, electrolyte concentration 3,000 mg/L and reaction time 240 min. While after optimization at current density 75 mA/cm2, electrolyte concentration 2,000 mg/L and reaction time 218 min a maximum of 49.33 and 59.24% removals were observed for COD and color respectively.

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Formulation Design and Optimization of Repaglinide Solid Dispersions by Central Composite Design

2018 ◽  
Vol 11 (6) ◽  
pp. 4337-4348
Author(s):  
Bhikshapathi D. V. R. N. ◽  
Srinivas I
Keyword(s):  
Central Composite Design ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Solvent Evaporation ◽  
Release Mechanism ◽  
Solvent Evaporation Method ◽  
Onset Of Action ◽  
Evaporation Method ◽  
Central Composite

Repaglinide is a pharmaceutical drug used for the treatment of type II diabetes mellitus, it is characterized with poor solubility which limits its absorption and dissolution rate and delays onset of action. In the present study, immediate release solid dispersion of repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-factor, 3-level central composite design employed to study the effect of each independent variable on dependent variables. FTIR studies revealed that no drug excipient interaction takes place. From powder X-ray diffraction (p-XRD) and by scanning electron microscopy (SEM) studies it was evident that polymorphic form of repaglinide has been converted into an amorphous form from crystalline within the solid dispersion formulation. The correlation coefficient showed that the release profile followed Higuchi model anomalous behavior and hence release mechanism was indicative of diffusion. The obtained results suggested that developed solid dispersion by solvent evaporation method might be an efficacious approach for enhancing the solubility and dissolution rate of repaglinide.

Formulation and Optimization of 5-Fluorouracil Loaded Chitosan Nanoparticles Employing Central Composite Design

2012 ◽  
Vol 2 (4) ◽  
pp. 281-289
Author(s):  
Rattan Lal ◽  
Rakesh Kumar Marwaha ◽  
Deepti Pandita ◽  
Harish Dureja
Keyword(s):  
Central Composite Design ◽  
Chitosan Nanoparticles ◽  
Central Composite
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