Biogenic titanium nanoparticles (TiO2NPs) from Tricoderma citrinoviride extract: synthesis, characterization and antibacterial activity against extremely drug-resistant Pseudomonas aeruginosa

2020 ◽  
Author(s):  
Sagar Arya ◽  
Hiralal Sonawane ◽  
Siddharam Math ◽  
Popat Tambade ◽  
Manohar Chaskar ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Drug Resistant ◽  
Titanium Nanoparticles

scholarly journals In vitro Antibacterial Activity of Organic Extracts of Aloe barbadensis against Multi-drug resistant Pseudomonas aeruginosa Isolated from Wound Specimens

2018 ◽  
Vol 5 ◽  
pp. 69-76
Author(s):  
Mamata Adhikari ◽  
Anil Kumar Sah ◽  
Dev Raj Joshi
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Inhibitory Action ◽  
Therapeutic Option ◽  
Diffusion Method ◽  
Drug Resistant ◽  
Aloe Barbadensis ◽  
Organic Extracts ◽  
In Vitro Antibacterial Activity

Objectives: In order to investigate alternate therapeutic option, this study was carried out to assess the in vitro antibacterial activity of gel extract of Aloe barbadensis against multiple antibiotic resistant Pseudomonas aeruginosa isolated from wound specimens. Methods: A total of 180 different wound specimens collected in a hospital, were subjected to isolate and identify P. aeruginosa by cultural methods. Antibiotic susceptibility testing was done by Kirby- Bauer disc diffusion method to screen multidrug resistant isolates. A. barbadensis extracts were prepared using aqueous and organic solvents and their in vitro inhibitory action was evaluated by agar well diffusion methods. Results: Out of total, 38 (21.1%) of the wound specimens showed the occurrence of P. aeruginosa, among which 15 (39%) isolates were multi-drug resistant. Organic extracts of various concentrations (0.2 - 0.8 v/v %) inhibited 66.7% of MDR and all non-MDR (n = 23) P. aeruginosa with zone of inhibition ranging from 9.5 ±1.0 to 21.3 ± 2.2 mm but not by aqueous extract. A positive Pearson’s correlation (r=0.983) was found between antibacterial effect and concentrations of the extracts. The antibacterial activity of organic extracts was statistically associated with antibiotic resistance profile of the organism (p<0.05). Conclusion: Organic extracts of A. barbadensis revealed variable in vitro inhibitory action against both MDR and non-MDR P. aeruginosa isolated from wound specimens. Although further confirmation is needed, aloe gel extract may be applied as an alternate treatment option.

scholarly journals Characterization of the antibacterial activity of Bald’s eyesalve against drug resistant Staphylococcus aureus and Pseudomonas aeruginosa

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0208108 ◽  
Author(s):  
Amanda L. Fuchs ◽  
Alan J. Weaver ◽  
Brian P. Tripet ◽  
Mary Cloud B. Ammons ◽  
Martin Teintze ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Drug Resistant

UPLC/QTOF-MS/MS ANALYSIS AND ANTIBACTERIAL ACTIVITY OF Commiphora leptophloeos (Mart.) J. B. Gillett AGAINST MULTI-DRUG RESISTANT Staphylococcus aureus and Pseudomonas aeruginosa

2021 ◽  
pp. 100506
Author(s):  
Fernando Gomes Figueredo ◽  
Sonia Pereira Cabrera ◽  
Amanda Lins Bispo Monteiro ◽  
Tania Maria Sarmento da Silva ◽  
Jaime Ribeiro Filho ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Drug Resistant ◽  
Ms Analysis

scholarly journals Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa

2018 ◽  
Vol 62 (4) ◽  
pp. e02374-17 ◽  
Author(s):  
Ronald Domalaon ◽  
Yaroslav Sanchak ◽  
Linet Cherono Koskei ◽  
Yinfeng Lyu ◽  
George G. Zhanel ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Liver Carcinoma ◽  
Dodecanoic Acid ◽  
Drug Resistant ◽  
Hexadecanoic Acid ◽  
Hek 293 ◽  
Content Type ◽  
Extensively Drug Resistant ◽  
Clinical Interest

ABSTRACT A series of 16 short proline-rich lipopeptides (SPRLPs) were constructed to mimic longer naturally existing proline-rich antimicrobial peptides. Antibacterial assessment revealed that lipopeptides containing hexadecanoic acid (C16) possess optimal antibacterial activity relative to others with shorter lipid components. SPRLPs were further evaluated for their potential to serve as adjuvants in combination with existing antibiotics to enhance antibacterial activity against drug-resistant Pseudomonas aeruginosa. Out of 16 prepared SPRLPs, C12-PRP was found to significantly potentiate the antibiotics minocycline and rifampin against multidrug- and extensively drug-resistant (MDR/XDR) P. aeruginosa clinical isolates. This nonhemolytic C12-PRP is comprised of the heptapeptide sequence PRPRPRP-NH2 acylated to dodecanoic acid (C12) at the N terminus. The adjuvant potency of C12-PRP was apparent by its ability to reduce the MIC of minocycline and rifampin below their interpretative susceptibility breakpoints against MDR/XDR P. aeruginosa. An attempt to optimize C12-PRP through peptidomimetic modification was performed by replacing all l- to d-amino acids. C12-PRP demonstrated that it was amenable to optimization, since synergism with minocycline and rifampin were retained. Moreover, C12-PRP displayed no cytotoxicity against human liver carcinoma HepG2 and human embryonic kidney HEK-293 cell lines. Thus, the SPRLP C12-PRP is a lead adjuvant candidate that warrants further optimization. The discovery of agents that are able to resuscitate the activity of existing antibiotics against drug-resistant Gram-negative pathogens, especially P. aeruginosa, is of great clinical interest.

scholarly journals Antibacterial Activity of Fermented Korean Medicine Against Multi-drug Resistant Pseudomonas aeruginosa

KSBB Journal ◽  
2011 ◽  
Vol 26 (6) ◽  
pp. 543-551 ◽  
Author(s):  
Ji-Yeon Ryu ◽  
Young-Ja Park ◽  
Hyun-Soo Kim
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Drug Resistant ◽  
Korean Medicine
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