scholarly journals A Study of Synergistic Antibacterial Activity of Silver Nanoparticles with Antibiotics against Multi-Drug Resistant Pseudomonas aeruginosa in Intensive Care Units of A Tertiary Care Hospital

2018 ◽  
Vol 7 (11) ◽  
pp. 83-88
Author(s):  
Komal Mirlekar ◽  
Anjali Swami ◽  
Sujata Baveja ◽  
Shanta Shubhra Das
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Drug Resistant ◽  
Synergistic Antibacterial Activity

scholarly journals Antibiotic Resistance Pattern of Bacteria Isolated from Nosocomial Infection in Internal Surgery and Neurosurgery Intensive Care Unit (NICU) at a Tertiary Care Hospital in Tehran, Iran

2017 ◽  
Vol 14 (3) ◽  
pp. 1095-1102 ◽  
Author(s):  
Mohammad Javad Hosseini ◽  
Mohamad Kiarsi ◽  
Reza Golmohammadi ◽  
Reza Sadripour
Keyword(s):  
Antibiotic Resistance ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Resistance Pattern ◽  
Resistant Bacteria ◽  
Care Hospital ◽  
Drug Resistant ◽  
Antibiotic Resistance Pattern

ABSTRACT: Today, many studies doneregarding the antibiotic resistance showthose patients in intensive care units (ICUs) are more likely to develop drug resistant pathogens.Pathogens are the major cause of nosocomial infections in intensive care units. Knowledge of antibiotic resistance of pathogens in the hospital is very important for treatment. The recent study aims at identifying drug resistant pathogens and antibiotic resistance pattern in the intensive care units of a tertiary care hospital in Tehran. In other words, the main purpose of the recent study is understanding the degree to which the resistant bacteria, which cause nosocomial infections is spreading in the ICUs of a tertiary care hospital and to determine the antibiotic- resistance pattern of these bacteria in the ICUs of that hospital. The recent research is a retrospective and cross-sectional study that has been conducted on the files of all patients who were hospitalized in ICUs, internal surgery, and neurosurgery sections of Baqiyatallah Hospital in Tehran in a five-year period (March 2009 to February 2015) and who were diagnosed with nosocomial infection caused by resistant bacteria. According to the results of this research, most of the separated bacteria were: Acinetobacterbaumannii 39.45%, Pseudomonas aeruginosa 20.69% and the most common location for infection was respiratory tract (67.11%). Also the most common pathogen was Acinetobacterbaumannii which is resistant to most antibiotics.

scholarly journals Detection of SARS-CoV-2 and Other Infectious Agents in Lower Respiratory Tract Samples Belonging to Patients Admitted to Intensive Care Units of a Tertiary-Care Hospital, Located in an Epidemic Area, during the Italian Lockdown

2021 ◽  
Vol 9 (1) ◽  
pp. 185
Author(s):  
Adriana Calderaro ◽  
Mirko Buttrini ◽  
Sara Montecchini ◽  
Giovanna Piccolo ◽  
Monica Martinelli ◽  
...  
Keyword(s):  
Intensive Care ◽  
Respiratory Tract ◽  
Intensive Care Units ◽  
Lower Respiratory Tract ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Infectious Agents ◽  
Epidemic Area ◽  
Significant Difference

The aim of this study was the detection of infectious agents from lower respiratory tract (LRT) samples in order to describe their distribution in patients with severe acute respiratory failure and hospitalized in intensive care units (ICU) in an Italian tertiary-care hospital. LRT samples from 154 patients admitted to ICU from 27 February to 10 May 2020 were prospectively examined for respiratory viruses, including SARS-CoV-2, bacteria and/or fungi. SARS-CoV-2 was revealed in 90 patients (58.4%, 72 males, mean age 65 years). No significant difference was observed between SARS-CoV-2 positives and SARS-CoV-2 negatives with regard to sex, age and bacterial and/or fungal infections. Nonetheless, fungi were more frequently detected among SARS-CoV-2 positives (44/54, 81.4%, p = 0.0053). Candida albicans was the overall most frequently isolated agent, followed by Enterococcus faecalis among SARS-CoV-2 positives and Staphylococcus aureus among SARS-CoV-2 negatives. Overall mortality rate was 40.4%, accounting for 53 deaths: 37 among SARS-CoV-2 positives (mean age 69 years) and 16 among SARS-CoV-2 negatives (mean age 63 years). This study highlights the different patterns of infectious agents between the two patient categories: fungi were prevalently involved among SARS-CoV-2-positive patients and bacteria among the SARS-CoV-2-negative patients. The different therapies and the length of the ICU stay could have influenced these different patterns of infectious agents.

Etiology and outcomes for patients infected with HIV in intensive care units in a tertiary care hospital in China

2014 ◽  
Vol 87 (3) ◽  
pp. 366-374 ◽  
Author(s):  
Jiang Xiao ◽  
Wen Zhang ◽  
Yingxiu Huang ◽  
Yunfei Tian ◽  
Wenjing Su ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals High Prevalence of Antimicrobial Resistance Among Gram-Negative Isolated Bacilli in Intensive Care Units at a Tertiary-Care Hospital in Yucatán Mexico

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 588 ◽  
Author(s):  
Andrés H. Uc-Cachón ◽  
Carlos Gracida-Osorno ◽  
Iván G. Luna-Chi ◽  
Jonathan G. Jiménez-Guillermo ◽  
Gloria M. Molina-Salinas
Keyword(s):  
Escherichia Coli ◽  
Intensive Care ◽  
Antimicrobial Resistance ◽  
Intensive Care Units ◽  
High Resistance ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Gram Negative ◽  
Resistance Rates

Background and Objectives: Antimicrobial resistance (AMR) is increasing worldwide and imposes significant life-threatening risks to several different populations, especially to those in intensive care units (ICU). The most commonly isolated organisms in ICU comprise gram-negative bacilli (GNB), and these represent a leading cause of serious infections. This study was conducted to describe the prevalence of resistance in GNB isolated from patients in adults, pediatric, and neonatal ICU in a tertiary-care hospital in Mérida, Mexico. Materials and Methods: A retrospective study was done on samples collected in Neonatal (NICU), Pediatric (PICU) and Adult (AICU) ICU of Unidad Médica de Alta Especialidad, Instituto Mexicano del Seguro Social in Mérida, México. The identification of isolates and antimicrobial susceptibility testing were performed using an automated system. Results: A total of 517 GNB strains were isolated. The most common positive culture was bronchial secretions. Pseudomonas aeruginosa was the prevalent pathogen in NICU and PICU, whereas Escherichia coli was common in the AICU. Overall, GNB exhibited a high resistance rates for Ampicillin (95.85%), Cefuroxime (84.17%), Piperacillin (82.93%), Cefotaxime (78.07%), Ceftriaxone (77.41%), Aztreonam (75.23%), Cefazolin (75.00%), and Ceftazidime (73.19%). There are significant differences in the resistance rates of GNB from different ICUs for penicillins, cephalosporins, carbapenems and fluoroquinolones drugs. Escherichia coli (multidrug-resistant [MDR] = 91.57%, highly resistant microorganisms [HRMO] = 90.36%) and Acinetobacter baumannii (MDR = 86.79%, HRMO = 83.02%) exhibited the highest percentage of MDR and HRMO profiles. The prevalence of the extended-spectrum beta-lactamases (ESBL)-producing isolates was 83.13% in E. coli, 78.84% in Klebsiella pneumoniae, and 66.67% in Proteus mirabilis, respectively. Conclusions: The high resistance rates to drugs were exhibited by our GNB isolates. Continuous surveillance and control of the use of antimicrobials are urgently needed to reduce the emergence and spreading of MDR, HRMO, and/or ESBL-producing bacilli.

scholarly journals PREVALENCE AND DRUG RESISTANCE IN ACINETOBACTER SP. ISOLATED FROM INTENSIVE CARE UNITS PATIENTS IN PUNJAB, INDIA

2018 ◽  
Vol 11 (14) ◽  
pp. 88
Author(s):  
Tanvir Kaur ◽  
Chayanika Putatunda ◽  
Aroma Oberoi ◽  
Ashish Vyas ◽  
Gaurav Kumar
Keyword(s):  
Health Care ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Drug Resistant ◽  
Bacterial Isolates ◽  
Sensitivity Pattern ◽  
Acinetobacter Sp

Objective: This study was designed to study the prevalence and antibiotic susceptibility patterns of Acinetobacter sp. as isolated from patients lodged in intensive care units (ICUs) of a tertiary care hospital, Ludhiana, Punjab, India.Methods: The clinical samples were simultaneously streaked on Blood agar and MacConkey agar. The identification of the bacterial isolates was carried out with the aid of Gram stain, motility test and along with a combination of other commonly employed biochemical tests. The antimicrobial susceptibility testing (AST) of all the bacterial isolates was carried out on Muller-Hinton agar through Kirby-Bauer disc diffusion method.Results: Acinetobacter sp. formed a fair allowance contributing at 42% among all ICU culture positive samples. The respiratory tract samples had a major share at 63.15% for all samples attributed to be positive for Acinetobacter sp. nosocomial etiology. The antibiotic sensitivity pattern portrayed that more than 95% of Acinetobacter sp. isolates were multiple drug resistant (MDR) whereas >50% Acinetobacter sp. showed extensive drug resistant (XDR). The last resort for such Acinetobacter sp. nosocomial infections is left to colistin and polymyxin B.Conclusion: Acinetobacter sp. is a highly prevalent microorganism among ICU patients of Ludhiana, Punjab, India, while its potential to acquire resistance toward commonly used antibiotics represents it as a grave threat to the health-care industry, therefore signifying the need for its regular monitoring in the health-care setups.

Sign in / Sign up

Export Citation Format

Share Document