Association of short stature and obesity with cardio-metabolic risk factors in Iranian children and adolescents: the CASPIAN-V study

Author(s):  
Omid Safari ◽  
Hanieh-Sadat Ejtahed ◽  
Nazli Namazi ◽  
Ramin Heshmat ◽  
Reza Arjmand ◽  
...  
2021 ◽  
pp. 1-31
Author(s):  
Qianrang Zhu ◽  
Yue Dai ◽  
Jingxian Zhang ◽  
Wei Xie ◽  
Hui Zuo ◽  
...  

Abstract Purpose Zinc plays an important role in metabolic processes in human organisms and is indispensable in many enzymatic processes. To date, few studies have assessed the association between serum zinc and metabolic risk factors in children and adolescents. The aim of the present study was to examine whether serum zinc concentrations was associated with metabolic risk factors in Chinese children and adolescents. Methods This study was a cross-sectional analysis of data from the 2016-2017 China National Nutrition and Health Surveillance for Children and Nursing in Jiangsu Province. A total of 3241 participants aged 6 -17years were included. Metabolic risk factors included fasting glucose (FG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), systolic blood pressure and diastolic blood pressure. Data were analyzed using multivariable linear regression and generalized additive models, which were adjusted for age, gender, high sensitive C-reactive protein, estimated glomerular filtration rate, body mass index and region of residence, to assess the associations of serum zinc concentrations with metabolic risk factors. Results We observed a negative association between serum zinc concentrations and FG (coefficient = -0.532; 95% CI: -0.569, -0.495; p< 0.001). Moreover, TC (coefficient = 0.175 ; 95% CI 0.127, 0.222; p< 0.001), HDL-C (coefficient = 0.137 ; 95% CI 0.082, 0.193; p< 0.001) and LDL-C (coefficient = 0.195 ; 95% CI 0.128, 0.263; p< 0.001) were found to be positively associated with zinc levels. A generalized additive model showed that the negative association between serum zinc and FG was weak at lower serum zinc concentrations, and was stronger with the increase in serum zinc concentrations. Additionally, a U-shaped association between serum zinc and TG was observed. Conclusions Serum zinc concentrations were associated with FG, TC, TG, HDL-C and LDL-C levels in Chinese children and adolescents. Lower levels of serum zinc were more likely related to a poor metabolic status.


Metabolism ◽  
2004 ◽  
Vol 53 (5) ◽  
pp. 638-643 ◽  
Author(s):  
Mohamed A.A Moussa ◽  
Mayra Alsaeid ◽  
Thanaa M.K Refai ◽  
Nabila Abdella ◽  
Nashami Al-Sheikh ◽  
...  

2009 ◽  
Vol 155 (3) ◽  
pp. S6.e15-S6.e26 ◽  
Author(s):  
Stephen Cook ◽  
Peggy Auinger ◽  
Terry T.-K. Huang

2019 ◽  
Vol 7 (1) ◽  
pp. e000824 ◽  
Author(s):  
Yinkun Yan ◽  
Junting Liu ◽  
Xiaoyuan Zhao ◽  
Hong Cheng ◽  
Guimin Huang ◽  
...  

ObjectiveTo investigate the association of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with cardiometabolic risk factors in children and adolescents.Research design and methodsThis cross-sectional study consisted of 8460 children and adolescents aged 6–18 years from Chinese urban areas who underwent dual-energy X-ray absorptiometry scan and had metabolic risk factors measured.ResultsIn multivariate analysis adjusted for region, family income, age, puberty development, physical activity, and smoking, VAT and SAT were significantly associated with all metabolic risk factors for both sexes (all p<0.01). After additional adjustment for fat mass index, most of these associations remain significantly positive. In boys, SAT had greater ORs for all risk factors compared with VAT; in girls, however, SAT had greater odds for high triglycerides, smaller odds for high low-density lipid cholesterol, and similar odds for other risk factors compared with VAT. In addition, boys had greater magnitude of associations of SAT with high total cholesterol, high low-density lipid cholesterol, and low high-density lipid cholesterol compared with girls; no sex differences for VAT were observed.ConclusionsBoth abdominal VAT and SAT have adverse impacts on most of the cardiometabolic risk factors in youth. However, their relative contributions differ between sexes.


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