Summary. Introduction: A human health risk assessment is the process to estimate the nature and probability of adverse health effects in humans who may be exposed to various environmental factors. The purpose of the study was to analyze climatic parameters as potential health risk factors for the population of some municipalities of the Krasnoyarsk Region. Methods: We processed meteorological data of the state monitoring network in the Krasnoyarsk Region including the average, maximum, and minimum air temperatures measured every three hours in an automatic mode in accordance with a generally accepted international protocol. Climate characteristics were identified using the method of long-term distribution of average daily temperatures. To assess the climatic features of the Krasnoyarsk Region, we considered such parameters as the average seasonal temperature, dates of air temperature stable transition through zero, temperature waves, extreme daily temperature changes, and bioclimatic indices. Results: We analyzed climate characteristics as potential health risk factors for the population of six cities of the Krasnoyarsk Region (Achinsk, Kansk, Krasnoyarsk, Lesosibirsk, Minusinsk, and Norilsk) for the period from 1919 to 2019. Conclusion: Our findings may be used to establish the relationship between a combination of climatic factors and ambient air quality indices and morbidity and mortality of the local population; they can also contribute to predicting death rates in the region.