Factors affecting clinical outcome following treatment of early childhood caries under general anaesthesia: a two-year follow-up

Background: Our aim was to compare salivary levels of secretory immunoglobulin A (s-IgA) in children with early childhood caries (ECCG) and those who are caries-free (CFG) and verify these levels in a follow-up period after restorative treatment. Materials and methods: We selected 46 systemically healthy children in the complete primary dentition period, who were allocated into two groups: CFG (n = 23) and ECCG (dmf-s > 0; n = 23). Unstimulated whole saliva was obtained at baseline from both groups and during the follow-up period (7 days, 1, 2 and 3 months) in the ECCG group. The s-IgA was measured using an ELISA assay, and total protein was assessed using the Bradford method. We also evaluated the flow rate (mL/min), Streptococcus mutans and Lactobacillus spp. counting using selective media plaques. The data were submitted to statistical analysis using the software SPSS 20.0 (SPSS Inc, IL, USA) with a confidence interval set at 95%. Results: Salivary s-IgA levels were higher in baseline of ECCG than in CFG (p<0.05). No statistically significant differences were observed between s-IgA salivary levels at baseline and the evaluations after dental treatment in ECCG (p>0.05). However, we observed two different changes in s-IgA levels among participants: one group presented s-IgA reduction, and the other group demonstrated its maintenance. It was shown that patients from the ECCG group who presented a reduction in s-IgA levels during follow-up also showed a decrease in Streptococcus mutans and Lactobacillus spp. count (p<0.05), in contrast to patients who did not present this reduction. The flow rate and total protein were similar between groups (p>0.05). Conclusions: The present data support the idea that children with early childhood caries present higher levels of s-IgA in saliva than caries-free children. The restorative dental treatment does not have a significant influence on salivary levels of this immunoglobulin during the follow-up period.

Download Full-text

Can insoluble polysaccharide concentration in dental plaque, sugar exposure and cariogenic microorganisms predict early childhood caries? A follow-up study

Archives of Oral Biology ◽

10.1016/j.archoralbio.2015.04.003 ◽

2015 ◽

Vol 60 (8) ◽

pp. 1091-1097 ◽

Cited By ~ 11

Author(s):

T.M. Parisotto ◽

R. Stipp ◽

L.K.A. Rodrigues ◽

R.O. Mattos-Graner ◽

L.S. Costa ◽

...

Keyword(s):

Early Childhood ◽

Dental Plaque ◽

Early Childhood Caries ◽

Follow Up Study ◽

Childhood Caries

Download Full-text

Microbiota of Severe Early Childhood Caries before and after Therapy

Journal of Dental Research ◽

10.1177/0022034511421201 ◽

2011 ◽

Vol 90 (11) ◽

pp. 1298-1305 ◽

Cited By ~ 98

Author(s):

A.C.R. Tanner ◽

R.L. Kent ◽

P. Lif Holgerson ◽

C.V. Hughes ◽

C.Y. Loo ◽

...

Keyword(s):

Early Childhood ◽

Early Childhood Caries ◽

Lower Detection ◽

Before And After ◽

Dietary Component ◽

Prevotella Species ◽

Post Therapy ◽

Severe Early Childhood Caries ◽

Childhood Caries

Severe early childhood caries (ECC) is difficult to treat successfully. This study aimed to characterize the microbiota of severe ECC and evaluate whether baseline or follow-up microbiotas are associated with new lesions post-treatment. Plaque samples from 2- to 6-year-old children were analyzed by a 16S rRNA-based microarray and by PCR for selected taxa. Severe-ECC children were monitored for 12 months post-therapy. By microarray, species associated with severe-ECC (n = 53) compared with caries-free (n = 32) children included Slackia exigua (p = 0.002), Streptococcus parasanguinis (p = 0.013), and Prevotella species (p < 0.02). By PCR, severe-ECC-associated taxa included Bifidobacteriaceae (p < 0.001), Scardovia wiggsiae (p = 0.003), Streptococcus mutans with bifidobacteria (p < 0.001), and S. mutans with S. wiggsiae (p = 0.001). In follow-up, children without new lesions (n = 36) showed lower detection of taxa including S. mutans, changes not observed in children with follow-up lesions (n = 17). Partial least-squares modeling separated the children into caries-free and two severe-ECC groups with either a stronger bacterial or a stronger dietary component. We conclude that several species, including S. wiggsiae and S. exigua, are associated with the ecology of advanced caries, that successful treatment is accompanied by a change in the microbiota, and that severe ECC is diverse, with influences from selected bacteria or from diet.

Download Full-text

Minimally Invasive Dentistry: Parent/Carer Perspectives on Atraumatic Restorative Treatments and Dental General Anaesthesia to the Management of Early Childhood Caries

Frontiers in Oral Health ◽

10.3389/froh.2021.656530 ◽

2021 ◽

Vol 2 ◽

Author(s):

Peter Arrow ◽

Helen Forrest ◽

Susan Piggott

Keyword(s):

Early Childhood ◽

Minimally Invasive ◽

General Anaesthesia ◽

Early Childhood Caries ◽

Cost Of Care ◽

Atraumatic Restorative Treatment ◽

Treatment Needs ◽

Minimally Invasive Dentistry ◽

Dental General Anaesthesia ◽

Childhood Caries

Introduction: Parents of children treated under dental general anaesthesia (DGA) have reported feelings of concern and anxiety. This study elicited the views of parents/carers (P/C) of children with early childhood caries (ECC) who participated in a randomised trial (core study) which tested the effectiveness of care under DGA or care using alternative minimally invasive Atraumatic Restorative Treatment and the Hall Technique approaches (ART/HT).Methods: P/C of children treated using the ART/HT (test) approach or care under a DGA (control) were interviewed. Focus group semi-structured interviews with P/C were undertaken in community facilities. The transcripts were read and inductively coded into domains to identify emergent themes. The codes were entered into NVivo software to assist data management and were further refined into broad themes.Results: Seven grouped interviews with 14 participants were conducted and one test participant provided a written response. Four groups with eight test participants; two groups with four control participants; and one combined group with one test and one control participant were interviewed. Five broad themes emerged after thematic analysis: (1) Impacts on the child and the family; (2) Child-/family-centred care; (3) Timeliness of care; (4) Affordable care; (5) Accessible care. Impacts were related to that of the effects of the disease, and of the care for the disease. Child-centred/family-centred care (CCC) was a source of appreciation by P/C of both groups when it was experienced. Frustration at the lack of timely care of their child's treatment needs, coupled with the perceived expensiveness of care and difficulties in physically getting to the location for a specialist consultation was expressed by P/Cs in the study.Discussion: The use of the ART/HT enabled the establishment of a relationship between the clinical team and the child and P/C which was central to the delivery of CCC. P/Cs in the DGA arm of the study expressed dissatisfaction more often with the issues of timely care, cost of care and accessibility of care. P/C of both groups were equally satisfied with the treatment, where treatment had been received in a timely, child-centred manner.Conclusion: The findings suggest that minimally invasive approaches which facilitated CCC are acceptable alternative options to the DGA and should be considered for the management of ECC.Australian New Zealand Clinical Trials Registry: ACTRN12616001124426.

Download Full-text

Correlation between dental caries and hormonal, biochemical parameters in children with early childhood caries

International Dental Research ◽

10.5577/intdentres.2020.vol10.no1.1 ◽

2020 ◽

Vol 10 (1) ◽

pp. 1-5

Author(s):

Ahmet Aras ◽

Mehmet Sinan Doğan

Keyword(s):

Early Childhood ◽

Uric Acid ◽

Statistical Analysis ◽

Dental Caries ◽

General Anaesthesia ◽

Biochemical Parameters ◽

Early Childhood Caries ◽

Pediatric Patients ◽

Radiographic Examination ◽

Childhood Caries

Aim: The aim of this study was to analyze the relationship between dental caries and hormonal, biochemical parameters in pediatric patients with early childhood caries (ECC). Methodology: This study was conducted on fifty pediatric patients who presented with complaints of pain and caries and underwent dental treatment under general anaesthesia. In this study, the hormonal, biochemical parameters (glucose, urea, uric acid, creatinine, AST, ALT, GGT, CRP, Sodium, Potassium, Calcium, Glucose, Iron, TSH, FT3 and FT4) which were routinely taken from patients before general anaesthesia and the number of decayed, extracted and filled teeth (DMFT) obtained as a result of clinical and radiographic examination were evaluated statistically in patients aged 2-6 years. Statistical analysis was performed using Independent Samples T-Test and Spearman correlation coefficient at a 0.05% significance level. Results: According to the data obtained, DMFT average of fifty children (male: 35; female: 15) included in the study was found to be 8.26. The mean DMFT was 7.93 in females and 8.40 in males. No statistical relationship was found between DMFT and gender in statistical analysis. (p>0.05). Uric acid and GGT values, which are among the hormonal and biochemical parameters, were found to be outside the normal range in 61.22% of the patients. However, statistical analysis revealed that there was no significant relationship between DMFT and hormonal, biochemical parameters. (p>0.05). Conclusions: In this study, it was concluded that dental caries did not cause a significant change in hormonal and biochemical blood parameters in pediatric patients with ECC. How to cite this article: Aras A, Doğan MS. Correlation between dental caries and hormonal, biochemical parameters in children with early childhood caries. Int Dent Res 2020;10(1):1-5. https://doi.org/10.5577/intdentres.2020.vol10.no1.1 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Download Full-text