Responsiveness on metabolic syndrome criteria and hepatic parameters after 12 weeks and 24 weeks of multidisciplinary intervention in overweight adolescents

OBJECTIVE: To compare the prevalence of metabolic abnormalities (MA) and metabolic syndrome (MS) assessed by different criteria among Brazilian adolescents. SUBJECTS AND METHODS: Weighted prevalence of MA and MS were estimated using criteria adapted from the International Diabetes Federation (IDF), National Cholesterol Education Program, Adult Treatment Panel III (NCEP/ATP III), and the World Health Organization (WHO) in a probabilistic sample of 577 students aged 12-19. RESULTS: The most prevalent MA was low concentration of HDL-C as per IDF (32.5%) and NCEP/ATP III (41.6%) criteria and hypertension as per the WHO's criterion (12.4%). Prevalence of MS using the NCEP/ATP III criterion (6.04%) was five times higher than the WHO's (1.1%) and the IDF's (1.6%) criteria. As expected, MS was significantly higher among overweight than among non-overweight adolescents. CONCLUSION: Low prevalence of MS but high prevalence of some MA were found. These findings suggest that the diagnosis of MA is more relevant in clinical practice especially in overweight adolescents.

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Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents

American Journal of Clinical Nutrition ◽

10.1093/ajcn/82.6.1178 ◽

2005 ◽

Vol 82 (6) ◽

pp. 1178-1184 ◽

Cited By ~ 185

Author(s):

Carine Klein-Platat ◽

Jocelyne Drai ◽

Mohamed Oujaa ◽

Jean-Louis Schlienger ◽

Chantal Simon

Keyword(s):

Metabolic Syndrome ◽

Fatty Acid Composition ◽

Fatty Acid ◽

Acid Composition ◽

Low Grade ◽

Plasma Fatty Acid ◽

The Metabolic Syndrome ◽

Plasma Fatty Acid Composition ◽

Overweight Adolescents ◽

Low Grade Inflammation

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Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat

Applied Physiology Nutrition and Metabolism ◽

10.1139/h10-033 ◽

2010 ◽

Vol 35 (4) ◽

pp. 464-470 ◽

Cited By ~ 8

Author(s):

Gisele Queiroz Carvalho ◽

Patrícia Feliciano Pereira ◽

Hiara Miguel Stancioli Serrano ◽

Sylvia do Carmo Castro Franceschini ◽

Sérgio Oliveira de Paula ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Fat ◽

Inflammatory Markers ◽

Female Adolescents ◽

Fat Percentage ◽

Positive Correlation ◽

The Metabolic Syndrome ◽

Tnf Α ◽

Group A ◽

Overweight Adolescents

The objective of this study was to evaluate the peripheral expression of inflammatory markers in adolescents with different nutritional status and its correlation with parameters of the metabolic syndrome. Seventy-two female postpubescent adolescents were divided into 3 groups: eutrophic (Co), eutrophic with a high body fat percentage (HBF), and overweight (OW). Data related to the parameters of the metabolic syndrome and the peripheral expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 were evaluated. Higher values of glycemia and insulin resistance were found in the HBF group than in the Co group. No differences related to the peripheral expression of the cytokines were found among the groups. In the HBF group, a positive correlation was observed between TNF-α and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. In the OW group, a positive correlation was found between IL-6 and triglycerides. Adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents. This suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents. The positive correlation between IL-10 and TNF-α and IL-6 suggests an attempt to inhibit the production of these cytokines by IL-10.

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