Renal toxicity of anticancer agents targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs)

2016 ◽  
Vol 30 (2) ◽  
pp. 171-180 ◽  
Author(s):  
Laura Cosmai ◽  
Maurizio Gallieni ◽  
Wanda Liguigli ◽  
Camillo Porta
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Anticancer Agents ◽  
Renal Toxicity ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Psoriatic Arthritis during Treatment with Bevacizumab for Anaplastic Oligodendroglioma

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
D. Graceffa ◽  
E. Maiani ◽  
A. Pace ◽  
F. M. Solivetti ◽  
F. Elia ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Vascular Endothelial Growth Factor ◽  
Psoriatic Arthritis ◽  
Growth Factor ◽  
Malignant Glioma ◽  
Anticancer Agents ◽  
Anaplastic Oligodendroglioma ◽  
Vascular Endothelial ◽  
History Of ◽  
Endothelial Growth Factor

Bevacizumab is a recombinant humanised monoclonal antibody directed against the vascular endothelial growth factor (VEGF). The drug, alone or in combination with other anticancer agents, has been shown to be effective against several types of neoplasms. We report a case of a woman with a history of severe psoriasis who developed psoriatic arthritis during a course of bevacizumab, which was administered for a malignant glioma.

scholarly journals Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands

2021 ◽  
Vol 22 (4) ◽  
pp. 1711
Author(s):  
Huang Zeng ◽  
Shuangshuang Kang ◽  
Yu Zhang ◽  
Ke Liu ◽  
Qian Yu ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Oleanolic Acid ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Vascular Endothelial ◽  
G Quadruplex ◽  
Selective Ligands ◽  
And Migration ◽  
Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is an angiogenic growth factor and plays a key role in tumor progression. The C-rich DNA sequence of VEGF promoter can form i-motif structure, which is a potential target for the development of novel anticancer agents. However, there is a limited number of chemotypes as the selective ligands of VEGF promoter i-motif, which leaves much room for development. Herein, we report the discovery of the natural oleanolic acid scaffold as a novel chemotype for the development of selective ligands of VEGF i-motif. A series of oleanolic acid derivatives as VEGF promoter i-motif ligands were synthesized. Subsequent evaluations showed that 3c could selectively bind to and stabilize VEGF promoter i-motif without significant binding to G-quadruplex, duplex DNA, and other oncogene i-motifs. Cell-based assays indicated that 3c could effectively downregulate VEGF gene transcription and expression in MCF-7 cells, inhibit tumor cells proliferation and migration, and induce cancer cells apoptosis. This work provides evidence of VEGF promoter i-motif as an anticancer target and will facilitate future efforts for the discovery of oleanolic acid-based selective ligands of VEGF promoter i-motif.

361: Serum Levels of Angiogenin and Vascular Endothelial Growth Factor (VEGF) Predict Metastatic Disease in Renal Cell Cancer Patients

2005 ◽  
Vol 173 (4S) ◽  
pp. 99-99 ◽  
Author(s):  
Marcus Horstmann ◽  
Axel S. Merseburger ◽  
Markus A. Kuczyk ◽  
Arnulf Stenzl ◽  
Karl-Horst Bichler ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Patients ◽  
Renal Cell Cancer ◽  
Metastatic Disease ◽  
Renal Cell ◽  
Cell Cancer ◽  
Serum Levels ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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