scholarly journals Hyperuricaemia, gout and allopurinol in the CKD Queensland registry

2021 ◽  
Author(s):  
A. Jeyaruban ◽  
W. Hoy ◽  
A. Cameron ◽  
H. Healy ◽  
Z. Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cardiovascular Events ◽  
Retrospective Cohort ◽  
Estimated Glomerular Filtration Rate ◽  
Serum Urate ◽  
Ckd Progression ◽  
Serum Urate Level ◽  
Kidney Replacement Therapy ◽  
Ckd.Qld Registry

Abstract Introduction There is scant data on the role of hyperuricaemia, gout and allopurinol treatment in chronic kidney disease (CKD). Therefore, our aim is to investigate the possible associations between hyperuricaemia, gout, prescription of allopurinol and renal outcomes in patients with CKD. Methods The retrospective cohort study involved 1123 Royal Brisbane and Women’s Hospital (RBWH) patients, enrolled in the CKD.QLD registry from May 2011 to August 2017. Patients were divided into two uric acid categories, with uric acid ≤ 0.36 mmol/L and > 0.36 mmol/L. Association of delta estimated glomerular filtration rate (eGFR) with gout, allopurinol treatment and hyperuricaemia were analysed. Results Patients with an entry urate > 0.36 mmol/L were older, had higher body mass index (BMI) and worse baseline kidney function. Proportion of patients with gout, hyperuricaemia and allopurinol treatment increased with advanced CKD stages. Age-adjusted analysis revealed a significant association between serum urate level and delta eGFR, with no significant association between gout, treatment with allopurinol and delta eGFR. Furthermore, neither gout nor the prescription of allopurinol had a significant effect on the time to renal death (composite end point of kidney replacement therapy or death). Conclusion Hyperuricaemia seemed to be independently associated with faster CKD progression or renal death. This was not observed with gout or prescription of allopurinol. Furthermore, allopurinol was not associated with decreased incidence of cardiovascular events. These data suggest that hyperuricaemia is likely the effect and not the cause of CKD or CKD progression. Graphic abstract

Gender Differences in the Role of Serum Uric Acid for Predicting Cardiovascular Events in Patients with Coronary Artery Disease

2007 ◽  
Vol 37 (5) ◽  
pp. 196 ◽  
Author(s):  
Dae-Woo Hyun ◽  
Ki-Hong Kim ◽  
Hyun-Ju Yoon ◽  
Taek-Geun Kwon ◽  
Ki-Young Kim ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Gender Differences ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Cardiovascular Events ◽  
Artery Disease

Application of UHPLC/ESI-Q-TOF-MS/MS to Identify Constituents of Erding Granule and Anti-hyperuricemia Effect

2019 ◽  
Vol 15 (5) ◽  
pp. 465-486 ◽  
Author(s):  
Haifang Chen ◽  
Yun Yao ◽  
Yuan Zhan ◽  
Hui Jian ◽  
Yan Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Chemical Constituents ◽  
Serum Urate ◽  
Chemical Information ◽  
Upper Respiratory Tract ◽  
Serum Urate Level ◽  
Tof Ms

Background: Erding granule (EDG) widely used as an agent with the effect of heat-clearing, detoxifying, eliminating dampness, relieving jaundice and upper respiratory tract disease in clinical application, but the systematic chemical information and anti-hyperuricemia effect of EDG was still unclear. Methods: An ultra-high performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC/ESI-Q-TOF-MS/MS) method was utilized to rapidly identify the chemical constituents of EDG. The anti-hyperuricemia effect of EDG was evaluated based on the effect on xanthine oxidase inhibitory activity (in vitro) and lowering uric acid (in vivo). Results: 198 compounds were tentatively separated and identified or characterized within 30 min by UHPLC/ESI-Q-TOF MS/MS. These compounds were categorized as 22 coumarins, 38 flavones, 67 alkaloids, 36 organic acids, 16 sesquiterpenes, 14 lignans and 5 the others constituents. Meanwhile, EDG significantly decreases the serum urate level of hyperuricemic mice induced by potassium oxonate, while EDG did not significantly decrease the serum urate level of hyperuricemic mice induced by hypoxanthine and activity of xanthine oxidase in vitro. Conclusion: The method developed was rapid and sensitive to characterize the chemical constituents of EDG, and provide a systematic view of chemical information for EDG. Furthermore, we first discovered the anti-hyperuricemia effect of EDG and it would further provide the reference for clarifying the mechanism of EDG on lowering uric acid.

scholarly journals Prognostic Factors of Fatal and Nonfatal Cardiovascular Events in Patients With Type 2 Diabetes: The Role of Renal Function Biomarkers

2021 ◽  
Author(s):  
Stefanos Roumeliotis ◽  
Vassilios Liakopoulos ◽  
Athanasios Roumeliotis ◽  
Aikaterini Stamou ◽  
Stylianos Panagoutsos ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Cardiovascular Events ◽  
Prognostic Value ◽  
Estimated Glomerular Filtration Rate ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
History Of

In this study, 158 patients with different degrees of renal function were followed for 7 years to assess the prognostic value of various risk factors, including carotid intima media thickness (cIMT) and biomarkers of renal function, for incident cardiovascular (CV) morbidity and mortality in patients with type 2 diabetes. The investigators found that estimated glomerular filtration rate, <a>albuminuria, and history of cardiovascular disease (CVD) can be used for prognosis of CVD, whereas cIMT adds little to the accuracy of this prediction.</a>

scholarly journals PKD2 influence uric acid levels and gout risk by interacting with ABCG2

2018 ◽  
Author(s):  
Zheng Dong ◽  
Jingru Zhou ◽  
Shuai Jiang ◽  
Yuan Li ◽  
Dongbao Zhao ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Uric Acid ◽  
Mrna Expression ◽  
Elevated Serum ◽  
Serum Urate ◽  
Purine Metabolism ◽  
The Other ◽  
Epistatic Interactions ◽  
First Time

AbstractBackgroundUric acid is the final product of purine metabolism and elevated serum urate levels can cause gout. Conflicting results were reported for the effect of PKD2 on serum urate levels and gout risk. Therefore, our study attempted to state the important role of PKD2 in influencing the pathogenesis of gout.MethodSNPs in PKD2 (rs2725215 and rs2728121) and ABCG2 (rs2231137 and rs1481012) were tested in approximately 5,000 Chinese individuals.ResultsTwo epistatic interactions between loci in PKD2 (rs2728121) and ABCG2 (rs1481012 and rs2231137) showed distinct contributions to uric acid levels with Pint values of 0.018 and 0.004, respectively, and the associations varies by gender and BMI. The SNP pair of rs2728121 and rs1481012 justly played roles in uric acid in females (Pint = 0.006), while the other pair did in males (Pint = 0.017). Regarding BMI, the former SNP pair merely contributed in overweigh subjects (Pint = 0.022) and the latter one did in both normal and overweigh individuals (Pint = 0.013 and 0.047, respectively). Furthermore, the latter SNP pair was also associated with gout pathology (Pint = 0.001), especially in males (Pint = 0.001). Finally, functional analysis showed potential epistatic interactions in those genes region and PKD2 mRNA expression had a positive correlation with ABCG2’s (r = 0.743, P = 5.83e-06).ConclusionOur study for the first time identified that epistatic interactions between PKD2 and ABCG2 influenced serum urate concentrations and gout risk, and PKD2 might affect the pathogenesis from elevated serum urate to hyperuricemia to gout by modifying ABCG2.

scholarly journals The association between uric acid levels and renal function of CKD patients with hyperlipidemia: a sub-analysis of the ASUCA trial

2019 ◽  
Vol 24 (5) ◽  
pp. 420-426
Author(s):  
Yoshihiro Kuwabara ◽  
Shinji Yasuno ◽  
Masato Kasahara ◽  
Kenji Ueshima ◽  
Kazuwa Nakao
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Uric Acid ◽  
Kidney Disease ◽  
Estimated Glomerular Filtration Rate ◽  
Trial Period ◽  
Ongoing Clinical Trial ◽  
Ckd Progression ◽  
Lowering Therapy ◽  
The Relationship

Abstract Background The influence of uric acid (UA) on renal function and the significance of UA-lowering therapy are unclear. The purpose of the sub-analysis of the Assessment of Clinical Usefulness in chronic kidney disease patients with Atorvastatin (ASUCA) trial was to evaluate the influence of serum UA levels on renal function in Japanese chronic kidney disease patients with hyperlipidemia. Methods Of 344 participants in the ASUCA trial, 279 participants whose UA levels at both baseline and 24 months were available were included. Based on UA level at baseline or mean UA level during the trial period, they were divided into four groups: < 5.0, 5.0–6.0, 6.0–7.0, or ≥ 7.0 mg/dL, irrespective of allocation. Changes in the estimated glomerular filtration rate (eGFR) after 24 months were compared among the groups in relation to baseline or mean UA levels. Results For baseline UA levels (< 5.0, 5.0–6.0, 6.0–7.0, or ≥ 7.0 mg/dL), the change in eGFR after 24 months was − 1.32 ± 10.3, − 1.74 ± 8.94, − 2.53 ± 7.34, and − 3.51 ± 9.10 mL/min/1.73 m2, respectively. A negative correlation between changes in eGFR after 24 months and baseline UA level was observed with adjustment for confounding factors. The relationship between changes in eGFR and mean UA levels during trial period showed a similar trend. Conclusion In CKD patients with dyslipidemia, hyperuricemia was an independent risk factor for CKD progression. An ongoing clinical trial (TARGET-UA, UMIN-ID 000,026,741) may reveal the significance of strict UA-lowering therapy in CKD patients.

scholarly journals Prognostic Factors of Fatal and Nonfatal Cardiovascular Events in Patients With Type 2 Diabetes: The Role of Renal Function Biomarkers

2021 ◽  
Author(s):  
Stefanos Roumeliotis ◽  
Vassilios Liakopoulos ◽  
Athanasios Roumeliotis ◽  
Aikaterini Stamou ◽  
Stylianos Panagoutsos ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Cardiovascular Events ◽  
Prognostic Value ◽  
Estimated Glomerular Filtration Rate ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
History Of

In this study, 158 patients with different degrees of renal function were followed for 7 years to assess the prognostic value of various risk factors, including carotid intima media thickness (cIMT) and biomarkers of renal function, for incident cardiovascular (CV) morbidity and mortality in patients with type 2 diabetes. The investigators found that estimated glomerular filtration rate, <a>albuminuria, and history of cardiovascular disease (CVD) can be used for prognosis of CVD, whereas cIMT adds little to the accuracy of this prediction.</a>

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