Here our purpose is to explore the entropy generation in nanofluid MHD flow by curved stretching sheet; second-order slip is considered. Additional effects of viscous dissipation, Joule heating, and activation energy are taken. Temperature and concentration boundary conditions are considered convectively. For convergence of series solution NDSolve MATHEMATICA is used. Velocity, Bejan number, concentration, temperature, and entropy generation graphs are sketched for important parameters. For greater estimations of first- and second-order velocity slip parameters fluid velocity reduces. The thermal and solutal Biot numbers enhance the temperature and concentration, respectively. The concentration also has direct relation with activation energy. Entropy generation reduces for chemical reaction parameter and first- and second-order slip parameters.