scholarly journals A Short-term Psychological Intervention for People Living with HIV During the First Wave of COVID-19

2021 ◽  
Author(s):  
Lisa Koski ◽  
Marie-Josée Brouillette ◽  
Nancy E. Mayo ◽  
Susan C. Scott ◽  
Lesley K. Fellows ◽  
...  
Keyword(s):  
Psychological Intervention ◽  
People Living With Hiv ◽  
Short Term ◽  
Living With Hiv

scholarly journals 1325. Inpatient Initiation of ART Improves Short-Term Mortality in People Living with HIV

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S479-S479
Author(s):  
Jamie Campbell ◽  
Christopher Polk ◽  
Danya Roshdy ◽  
Michael Leonard
Keyword(s):  
Hospice Care ◽  
Intervention Group ◽  
People Living With Hiv ◽  
Virologic Suppression ◽  
Short Term ◽  
Patient Admissions ◽  
Short Term Mortality ◽  
Living With Hiv ◽  
The Impact

Abstract Background Treatment of HIV is recommended as soon as possible and early initiation of combined antiretroviral therapy (cART) is associated with improved engagement in care; however, treatment with cART is often deferred in hospitalized patients despite being correlated with improved outcomes. We implemented an institutional intervention to ensure all people living with HIV (PLwH) were on cART during hospitalization to improve patient outcomes. Methods We prospectively identified all PLwH hospitalized at our institution and had ID physicians and pharmacists ensure they were on appropriate cART and linked to outpatient care. We retrospectively collected clinical and lab data to assess the impact of our intervention on inpatient mortality, 30-day mortality, 30-day readmission rate, and frequency of outpatient follow-up. Patients were excluded from analysis if they were admitted for hospice care. Results We identified 389 patient admissions in 275 unique patients, of which 304 admissions were already on cART at admission. After ID physician assessment, 37 of the 85 not on cART at admission were initiated on therapy. We assessed the impact of this intervention on short-term outcomes as listed in Table 1. Despite the intervention group having similar immunologic and virologic baseline characteristics to those not initiated on cART, their inpatient and 30-day mortality was similar to those already on cART. Readmission rates also decreased in the intervention group. Thirteen of 24 patients in the intervention group who could be tracked for long-term follow-up within our system achieved virologic suppression by 90 days after hospital discharge. Conclusion Inpatient treatment with cART during hospitalization improves short-term mortality outcomes. This study also demonstrates the value of inpatient cART treatment as most patients achieved virologic suppression at subsequent outpatient follow-up. Disclosures All authors: No reported disclosures.

scholarly journals Repurposing of Chloroquine and Its Derivative, Hydroxychloroquine for COVID-19: Implications for People Living with HIV in Africa

2020 ◽  
Author(s):  
Chiagoziem Otuechere
Keyword(s):  
Immune System ◽  
Antiviral Agents ◽  
World Health ◽  
People Living With Hiv ◽  
Short Term ◽  
Confounding Variables ◽  
Immunodeficiency Virus ◽  
Proven Efficacy ◽  
Health Organization ◽  
Living With Hiv

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, has been declared by the World Health Organization (WHO) as a pandemic. Unfortunately, finding a vaccine or developing drugs from the scratch is a time-consuming luxury given the widespread and high fatality rates of the virus. In the short term, repurposing of drugs already in use seem to be the most rational step to quickly and effectively curb the virus. Several antiviral agents had been proposed as possible remedies, but the 4-aminoquinolines, Chloroquine (CHQ) and hydroxychloroquine (HCHQ) appear to be generating more interest. They are generic, cheaply available and have proven efficacy against malaria parasites in Africa. The human immunodeficiency virus (HIV), on the other hand, targets the immune system thereby reducing the patient’s ability to fight infections. Sadly, 68% of the global HIV burden occur in Africa. It is therefore anticipated that incidence of severe forms of COVID-19 could occur in Africa because of associated endemic conditions that compromise the immune system. With CHQ and HCHQ being considered for clinical use against COVID-19, there is a need to highlight their potential merits and confounding variables in the subgroup of patients with or without HIV.

A pilot assessment of water, sanitation, hygiene and home-based care services for people living with HIV/AIDS in rural and peri-urban communities in South Africa

2007 ◽  
Vol 56 (5) ◽  
pp. 125-131 ◽  
Author(s):  
N. Potgieter ◽  
R. Koekemoer ◽  
P. Jagals
Keyword(s):  
South Africa ◽  
Urban Communities ◽  
Service Provision ◽  
People Living With Hiv ◽  
Short Term ◽  
Care Services ◽  
Home Based ◽  
Living With Hiv ◽  
Home Based Care ◽  
Hiv Aids

A short-term assessment of water, sanitation, hygiene and home-based care services in two rural and two peri-urban communities in South Africa was made using specially designed questionnaires. The results from this assessment indicated the shortcomings of various sections in the service provision to people affected and living with HIV/AIDS in South Africa. This paper is a summarised version of the assessment and aims to give an indication of the inadequacies of some of these services.

scholarly journals Comparison of mHealth and Face-to-Face Interventions for Smoking Cessation Among People Living With HIV: Meta-Analysis (Preprint)

2017 ◽  
Author(s):  
Olalekan A Uthman ◽  
Chidozie U Nduka ◽  
Mustapha Abba ◽  
Rocio Enriquez ◽  
Helena Nordenstedt ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Treatment Effects ◽  
People Living With Hiv ◽  
Short Term ◽  
Smoking Cessation Treatment ◽  
Face To Face ◽  
Cessation Treatment ◽  
Meta Analyses ◽  
Living With Hiv

BACKGROUND The prevalence of smoking among people living with HIV (PLHIV) is higher than that reported in the general population, and it is a significant risk factor for noncommunicable diseases in this group. Mobile phone interventions to promote healthier behaviors (mobile health, mHealth) have the potential to reach a large number of people at a low cost. It has been hypothesized that mHealth interventions may not be as effective as face-to-face strategies in achieving smoking cessation, but there is no systematic evidence to support this, especially among PLHIV. OBJECTIVE This study aimed to compare two modes of intervention delivery (mHealth vs face-to-face) for smoking cessation among PLHIV. METHODS Literature on randomized controlled trials (RCTs) investigating effects of mHealth or face-to-face intervention strategies on short-term (4 weeks to <6 months) and long-term (≥6 months) smoking abstinence among PLHIV was sought. We systematically reviewed relevant RCTs and conducted pairwise meta-analyses to estimate relative treatment effects of mHealth and face-to-face interventions using standard care as comparison. Given the absence of head-to-head trials comparing mHealth with face-to-face interventions, we performed adjusted indirect comparison meta-analyses to compare these interventions. RESULTS A total of 10 studies involving 1772 PLHIV met the inclusion criteria. The average age of the study population was 45 years, and women comprised about 37%. In the short term, mHealth-delivered interventions were significantly more efficacious in increasing smoking cessation than no intervention control (risk ratio, RR, 2.81, 95% CI 1.44-5.49; n=726) and face-to-face interventions (RR 2.31, 95% CI 1.13-4.72; n=726). In the short term, face-to-face interventions were no more effective than no intervention in increasing smoking cessation (RR 1.22, 95% CI 0.94-1.58; n=1144). In terms of achieving long-term results among PLHIV, there was no significant difference in the rates of smoking cessation between those who received mHealth-delivered interventions, face-to-face interventions, or no intervention. Trial sequential analysis showed that only 15.16% (726/1304) and 5.56% (632/11,364) of the required information sizes were accrued to accept or reject a 25% relative risk reduction for short- and long-term smoking cessation treatment effects. In addition, sequential monitoring boundaries were not crossed, indicating that the cumulative evidence may be unreliable and inconclusive. CONCLUSIONS Compared with face-to-face interventions, mHealth-delivered interventions can better increase smoking cessation rate in the short term. The evidence that mHealth increases smoking cessation rate in the short term is encouraging but not sufficient to allow a definitive conclusion presently. Future research should focus on strategies for sustaining smoking cessation treatment effects among PLHIV in the long term.

scholarly journals Kaposi’s Sarcoma in Virally Suppressed People Living with HIV: An Emerging Condition

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5702
Author(s):  
Romain Palich ◽  
Alain Makinson ◽  
Marianne Veyri ◽  
Amélie Guihot ◽  
Marc-Antoine Valantin ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Universal Access ◽  
Case Series ◽  
Kaposi’S Sarcoma ◽  
People Living With Hiv ◽  
Short Term ◽  
Hiv Replication ◽  
Dead End ◽  
Living With Hiv ◽  
New Strategies

Since the advent of highly effective combined antiretroviral treatment (cART), and with the implementation of large HIV testing programs and universal access to cART, the burden of AIDS-related comorbidities has dramatically decreased over time. The incidence of Kaposi’s sarcoma (SK), strongly associated with HIV replication and CD4 immunosuppression, was greatly reduced. However, KS remains the most common cancer in patients living with HIV (PLHIV). HIV physicians are increasingly faced with KS in virally suppressed HIV-patients, as reflected by increasing description of case series. Though SK seem less aggressive than those in PLHIV with uncontrolled HIV-disease, some may require systemic chemotherapy. Persistent lack of specific anti-HHV-8 cellular immunity could be involved in the physiopathology of these KS. These clinical forms are a real therapeutic challenge without possible short-term improvement of anti-HHV-8 immunity, and no active replication of HIV to control. The cumulative toxicity of chemotherapies repeatedly leads to a therapeutic dead end. The introduction or maintenance of protease inhibitors in cART does not seem to have an impact on the evolution of these KS. Research programs in this emerging condition are important to consider new strategies.

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