scholarly journals Postoperative Sepsis Among HIV-Positive Patients with Acute Abdomen at Tertiary Hospital in Sub-Saharan Africa: a Prospective Study

2019 ◽  
Vol 1 (6) ◽  
pp. 465-472
Author(s):  
Mohamed Abdullahi Awale ◽  
Timothy Makumbi ◽  
Gideon Rukundo ◽  
Gideon K. Kurigamba ◽  
Geoffrey Kisuze ◽  
...  
Keyword(s):  
Prospective Study ◽  
Acute Abdomen ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
Hiv Positive ◽  
Postoperative Sepsis ◽  
Sub Saharan ◽  
A Prospective Study

scholarly journals Antigen-based diagnosis of Schistosoma infection in travellers: a prospective study

2020 ◽  
Vol 27 (4) ◽  
Author(s):  
Miriam Casacuberta-Partal ◽  
Jacqueline J Janse ◽  
Roos van Schuijlenburg ◽  
Jutte J C de Vries ◽  
Marianne A A Erkens ◽  
...  
Keyword(s):  
Prospective Study ◽  
Adult Worm ◽  
Signs And Symptoms ◽  
Diagnostic Value ◽  
Sub Saharan Africa ◽  
Enzyme Linked Immunosorbent Assay ◽  
Water Contact ◽  
Praziquantel Treatment ◽  
Sub Saharan ◽  
A Prospective Study

Abstract Background Travellers infected with Schistosoma spp. might be pauci- or even asymptomatic on first presentation. Therefore, schistosomiasis may remain undiagnosed in this population. Active infection, as evidenced by the presence of the tissue-dwelling worm, can be demonstrated via the detection of adult worm-derived circulating anodic antigen (CAA) utilising a robust well-described lateral flow-(LF) based test applying background-free up-converting reporter particles (UCP). In this prospective study, we assessed the diagnostic value of serum and urine UCP-LF CAA test in comparison with two Schistosoma-specific serological assays detecting antibodies against adult worm antigen-immuno fluorescence assay (AWA-IFA) and against soluble egg antigen–enzyme-linked immunosorbent assay (SEA-ELISA) antigens in travellers. Methods Samples were collected from 106 Dutch travellers who reported freshwater contact in sub-Saharan Africa and who were recruited up to 2 years after return. Subjects were asked to complete a detailed questionnaire on travel history, water contact, signs and symptoms compatible with schistosomiasis. Results Two travellers were positive by serum CAA and an additional one by urine CAA. A total of 22/106 (21%) samples were antibody positive by AWA-IFA and 9/106 (9%) by SEA-ELISA. At follow-up 6 weeks and 6 months after praziquantel treatment, all seropositives remained antibody positive whereas CAA was cleared. Seropositivity could not be predicted by the type of fresh water-related activity, country visited or symptoms reported. Conclusion The low number of UCP-LF CAA positives suggests that in travellers, active infections often do not establish or have very low worm burden. Based on our high seroconversion rates, we conclude that the AWA-IFA assay is the most sensitive test to detect schistosome exposure. Given the lack of predictive symptoms or risk factors, we recommend schistosomiasis screening at least by serology in all travellers with reported freshwater contact in high-endemic areas.

scholarly journals Outcomes of Dorsal and Ventral Buccal Graft Urethroplasty at a Tertiary Hospital in Uganda

ISRN Urology ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
S. Kaggwa ◽  
M. Galukande ◽  
H. Dabanja ◽  
H. Luweesi
Keyword(s):  
Success Rate ◽  
Buccal Mucosa ◽  
Tertiary Hospital ◽  
Sub Saharan Africa ◽  
Team Approach ◽  
Sexually Transmitted ◽  
Urethral Strictures ◽  
Sub Saharan ◽  
A Prospective Study

Purpose. Although the use of buccal mucosa in substitution urethroplasty has been practiced for some years, it has not been free of controversy over which surgical technique is the most appropriate to use. There is paucity of data in Sub-Saharan Africa about its success; this study presents the outcomes of dorsal and ventral buccal graft urethroplasty at a sub-Saharan tertiary hospital. Methods. This is a prospective study in which buccal mucosa was used for ventral and dorsal grafts; followup was up to two years. All patients provided informed written consent for the procedures. Results. Seventy-two patients with bulbar urethral strictures underwent buccal graft one-stage urethroplasty. Mean age was 55 years; etiology of the strictures was postinflammatory due to urethritis from sexually transmitted infections 97% (70/72) and trauma 3% (2/72). Buccal mucosa grafts were harvested from the cheek using a two-team approach. Grafts were placed on the ventral and dorsal urethral surfaces in 32 and 40 cases, respectively; the success rate was 84 and 80%, respectively. Repeated urethroplasty was successfully done among 10% (7/72) and patients reported resolution of symptoms in the follow-up period. Conclusion. There was no difference between dorsal and ventral onlay buccal graft outcomes for bulbar urethral strictures. The success rate was 80 to 84%.

scholarly journals Quality of Caesarean Sections in Rural Sub-Saharan Africa: A Prospective Study in Cameroon

2021 ◽  
Vol 11 (10) ◽  
pp. 1361-1377
Author(s):  
Jean Dupont Ngowa Kemfang ◽  
Jovanny Tsuala Fouogue ◽  
Adeline Christel Gwet ◽  
Arouna Ngapagna Njayou ◽  
Bruno Kenfack ◽  
...  
Keyword(s):  
Prospective Study ◽  
Sub Saharan Africa ◽  
Sub Saharan ◽  
A Prospective Study

scholarly journals Right Ventricular Systolic Dysfunction Is Common in Hypertensive Heart Failure: A Prospective Study in Sub-Saharan Africa

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153479 ◽  
Author(s):  
Dike B. Ojji ◽  
Sandrine Lecour ◽  
John J. Atherton ◽  
Lori A. Blauwet ◽  
Jacob Alfa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Prospective Study ◽  
Right Ventricular ◽  
Systolic Dysfunction ◽  
Sub Saharan Africa ◽  
Ventricular Systolic Dysfunction ◽  
Sub Saharan ◽  
A Prospective Study

scholarly journals Adverse Drug Reactions in Paediatric In-Patients in a South African Tertiary Hospital

2018 ◽  
Vol 65 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Memela Makiwane ◽  
Eric Decloedt ◽  
Maxwell Chirehwa ◽  
Bernd Rosenkranz ◽  
Mariana Kruger
Keyword(s):  
South African ◽  
Tertiary Hospital ◽  
Paediatric Oncology ◽  
Sub Saharan Africa ◽  
Severity Scale ◽  
Probability Scale ◽  
Period Data ◽  
Sub Saharan ◽  
A Prospective Study ◽  
Reason For Admission

Abstract Background The prevalence of adverse drug reaction (ADR) rates in children in sub-Saharan Africa is unknown. Objectives To describe the prevalence of ADRs in paediatric in-patients at a tertiary hospital in South Africa. Methods This is a prospective study during a 3-month study period. Data collected included age, sex, diagnosis, medicines received and ADRs experienced. Causality were assessed, using the 10-question Naranjo probability scale and classified according to the Hartwig severity scale. Results There were 61 ADRs in 18.4% (52 of 282) of patients. Median age of patients was 1.4 years (interquartile range: 0.5–5.3 years). ADR was the primary admission reason in 31%. The majority of the ADRs were moderate 45.9% (28 of 61), and only 11.5% severe (7 of 61). Paediatric oncology patients suffered significantly more ADRs (56.5%; 13 of 23) [odds ratio 7.3 (3.0–17.9), p < 0.01], followed by HIV-infected patients (42.9%; 9 of 21). Conclusion The prevalence of ADRs was 18.4%, while 31% was the reason for admission.

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