Comparative evaluation of the antimicrobial effect of electric plasma in textile between a standard strain of Klebsiella pneumoniae and a resistant clinical strain (KPC)

2021 ◽  
Author(s):  
Amanda Cerquearo Rodrigues dos Santos ◽  
Guilherme Rodrigues Teodoro ◽  
Sônia Khouri Sibelino
Keyword(s):  
Klebsiella Pneumoniae ◽  
Comparative Evaluation ◽  
Antimicrobial Effect ◽  
Clinical Strain ◽  
Standard Strain

scholarly journals Imipenem Resistance in a Salmonella Clinical Strain Due to Plasmid-Mediated Class A Carbapenemase KPC-2

2003 ◽  
Vol 47 (4) ◽  
pp. 1297-1300 ◽  
Author(s):  
Vivi Miriagou ◽  
Leonidas S. Tzouvelekis ◽  
Shannon Rossiter ◽  
Eva Tzelepi ◽  
Frederick J. Angulo ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Klebsiella Pneumoniae ◽  
Salmonella Enterica ◽  
Conjugative Plasmid ◽  
Clinical Strain ◽  
Class A ◽  
Potential Association ◽  
Imipenem Resistance ◽  
Flanking Regions

ABSTRACT A Salmonella enterica serotype Cubana isolate exhibiting resistance to most β-lactam antibiotics, including oxyimino-cephalosporins and imipenem, was isolated from a 4-year-old boy with gastroenteritis in Maryland. β-Lactam resistance was mediated by a conjugative plasmid that encoded KPC-2, a class A carbapenemase previously found in a Klebsiella pneumoniae isolate from the Maryland area as well. Sequence analysis of the flanking regions indicated a potential association of bla KPC-2 with mobile structures.

scholarly journals Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from Klebsiella pneumoniae

2008 ◽  
Vol 52 (10) ◽  
pp. 3792-3794 ◽  
Author(s):  
Véronique Dubois ◽  
Laurent Poirel ◽  
François Demarthe ◽  
Corinne Arpin ◽  
Laure Coulange ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Biochemical Characterization ◽  
Clinical Strain ◽  
Chromosomal Gene ◽  
Inhibitor Resistance ◽  
Critical Site ◽  
Single Substitution

ABSTRACT A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla SHV-56, encoding a new inhibitor-resistant β-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resistance among SHV enzymes.

scholarly journals Draft Genome Sequence of a Polymyxin-Resistant Klebsiella pneumoniae Clinical Strain Carrying mcr-8.1 and blaNDM-5

2021 ◽  
Vol 10 (12) ◽  
Author(s):  
Na Pei ◽  
Zijuan Jian ◽  
Yirui Liu ◽  
Tianzhu Liang ◽  
Wenen Liu ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Global Health ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Clinical Strain ◽  
Content Type ◽  
Major Threat ◽  
Carbapenem Resistant

ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major threat to global health. Here, we report the draft genome sequence of a Klebsiella pneumoniae clinical strain carrying mcr-8.1 and blaNDM-5.

Insights into a novel Tn4401 deletion (Tn4401i) in a multidrug-resistant Klebsiella pneumoniae clinical strain belonging to the high-risk clonal group 258 producing KPC-2

2018 ◽  
Vol 52 (4) ◽  
pp. 525-527 ◽  
Author(s):  
Bruna Fuga Araújo ◽  
Sabrina Royer ◽  
Paola Amaral Campos ◽  
Melina Lorraine Ferreira ◽  
Iara Rossi Gonçalves ◽  
...  
Keyword(s):  
High Risk ◽  
Klebsiella Pneumoniae ◽  
Multidrug Resistant ◽  
Clinical Strain ◽  
Clonal Group

scholarly journals Coexistence Of Plasmid-Mediated mcr-1 And blaNDM-4 Genes In A Klebsiella pneumoniae Clinical Strain In Vietnam

2019 ◽  
Vol Volume 12 ◽  
pp. 3703-3707 ◽  
Author(s):  
Lien Le ◽  
Linh Khanh Tran ◽  
Tam-Duong Le-Ha ◽  
Bich-Phuong Tran ◽  
Hong-Ngoc Le-Vo ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Clinical Strain

scholarly journals Combined Use of the Ab105-2φΔCI Lytic Mutant Phage and Different Antibiotics in Clinical Isolates of Multi-Resistant Acinetobacter baumannii

2019 ◽  
Vol 7 (11) ◽  
pp. 556 ◽  
Author(s):  
Lucia Blasco ◽  
Anton Ambroa ◽  
Maria Lopez ◽  
Laura Fernandez-Garcia ◽  
Ines Bleriot ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Antimicrobial Effect ◽  
In Vivo Model ◽  
Clinical Strain ◽  
Resistant Bacteria ◽  
Lytic Phage ◽  
Combined Use ◽  
Lysogenic Phage

Phage therapy is an abandoned antimicrobial therapy that has been resumed in recent years. In this study, we mutated a lysogenic phage from Acinetobacter baumannii into a lytic phage (Ab105-2phiΔCI) that displayed antimicrobial activity against A. baumannii clinical strain Ab177_GEIH-2000 (isolated in the GEIH-REIPI Spanish Multicenter A. baumannii Study II 2000/2010, Umbrella Genbank Bioproject PRJNA422585, and for which meropenem and imipenem MICs of respectively, 32 µg/mL, and 16 µg/mL were obtained). We observed an in vitro synergistic antimicrobial effect (reduction of 4 log–7 log CFU/mL) between meropenem and the lytic phage in all combinations analyzed (Ab105-2phiΔCI mutant at 0.1, 1 and 10 MOI and meropenem at 1/4 and 1/8 MIC). Moreover, bacterial growth was reduced by 8 log CFU/mL for the combination of imipenem at 1/4 MIC plus lytic phage (Ab105-2phiΔCI mutant) and by 4 log CFU/mL for the combination of imipenem at 1/8 MIC plus lytic phage (Ab105-2phiΔCI mutant) at both MOI 1 and 10. These results were confirmed in an in vivo model (G. mellonella), and the combination of imipenem and mutant Ab105-2phiΔCI was most effective (p < 0.05). This approach could help to reduce the emergence of phage resistant bacteria and restore sensitivity to antibiotics used to combat multi-resistant strains of Acinetobacter baumannii.

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