critical site
Recently Published Documents


TOTAL DOCUMENTS

108
(FIVE YEARS 32)

H-INDEX

18
(FIVE YEARS 2)

Author(s):  
Gary E. Raskob ◽  
Alex C. Spyropoulos ◽  
Theodore E. Spiro ◽  
Wentao Lu ◽  
Zhong Yuan ◽  
...  

Background Thromboprophylaxis extended after hospital discharge in medically ill patients currently is not recommended by practice guidelines because of uncertainty about the benefit for preventing major or fatal thromboembolic events, and the risk of bleeding. Methods and Results We assessed the benefit and risk of thromboprophylaxis with rivaroxaban 10 mg once daily extended for 25 to 45 days after hospitalization for preventing major thromboembolism in medically ill patients using the pooled data in 16 496 patients from 2 randomized trials, MARINER (Medically Ill Patient Assessment of Rivaroxaban Versus Placebo in Reducing Post‐Discharge Venous Thrombo‐Embolism Risk) and MAGELLAN (Multicenter, randomized, parallel‐group efficacy and safety study for the prevention of venous thromboembolism in hospitalized medically ill patients comparing rivaroxaban with enoxaparin). The data from the MARINER trial were pooled with the data from the MAGELLAN trial in patients who were free of thrombotic or bleeding events up to the last dose of enoxaparin/placebo and who continued in the outpatient phase of thromboprophylaxis. The composite outcome of major thromboembolic events (symptomatic deep vein thrombosis, nonfatal pulmonary embolism, myocardial infarction, and nonhemorrhagic stroke) and all‐cause mortality was used to assess benefit and was compared with the risk of the composite of fatal and critical site bleeding. The incidence of the composite efficacy outcome was 1.80% (148 of 8222 patients) in the rivaroxaban group, compared with 2.31% (191 of 8274 patients in the placebo group) (HR, 0.78 [95% CI, 0.63–0.97], P =0.024). Fatal or critical site bleeding events were infrequent and occurred in <0.1% of patients in both groups (rivaroxaban 0.09%; placebo 0.04%; HR, 2.36; P =0.214). Conclusions The results suggest a benefit for reducing major thromboembolic outcomes (number needed to treat: 197), with a favorable trade‐off to fatal or critical site bleeding (number needed to harm: 2045). Registration URL: https://www.clinicaltrials.gov ; Unique identifiers: NCT00571649 and NCT02111564.


2021 ◽  

This collection of essays brings together theories of play and game with theatre and performance to produce new understandings of the history and design of early modern English drama. Through literary analysis and embodied practice, an international team of distinguished scholars examines a wide range of games—from dicing to bowling to roleplaying to videogames—to uncover their fascinating ramifications for the stage in Shakespeare's era and our own. Foregrounding ludic elements challenges the traditional view of drama as principally mimesis, or imitation, revealing stageplays to be improvisational experiments and participatory explorations into the motive, means, and value of recreation. Delving into both canonical masterpieces and hidden gems, this innovative volume stakes a claim for play as the crucial link between games and early modern theatre, and for the early modern theatre as a critical site for unraveling the continued cultural significance and performative efficacy of gameplay today.


Lateral ◽  
2021 ◽  
Author(s):  
Yannis Kallianos ◽  
Pafsanias Karathanasis

Our contribution puts forward an examination of public spaces as infrastructures of care. The eruption of the COVID-19 pandemic, and the “social distancing” measures imposed by several governments around the world, transformed the very use and conceptualization of urban public spaces. In Athens, Greece, public space, which had already been in different ways at the forefront of multifarious crises since 2010, reemerged, once again, as a critical site of sociopolitical antagonism. Public spaces, such as squares, became central places where people could come together to share knowledge and emotions, collectively alleviate anxieties, and thus (re)negotiate their positionality in the city. Such formations and enactments of social connection, affectivity, and antagonism, reflect the entanglement between everyday life and the political, and also draw attention to the association of public space with practices of care for collective well-being during precarious times. During the ever-increasing securitization and policing of urban spaces in Athens, in which everyday life has come to be ever more permeated by precarity and uncertainty, public spaces have been reenacted as safe and more inclusive environments where people can be and act together. Our contribution also employs a video to render more intelligible the affective interconnectedness of sounds, images, bodies, materialities, and practices in public space. By attending to the affective dynamics of a public square in central Athens, we examine the entanglements between the sociopolitical production of public space and forms of care during the COVID-19 pandemic.


2021 ◽  

This collection of essays brings together theories of play and game with theatre and performance to produce new understandings of the history and design of early modern English drama. Through literary analysis and embodied practice, an international team of distinguished scholars examines a wide range of games—from dicing to bowling to roleplaying to videogames—to uncover their fascinating ramifications for the stage in Shakespeare’s era and our own. Foregrounding ludic elements challenges the traditional view of drama as principally mimesis, or imitation, revealing stageplays to be improvisational experiments and participatory explorations into the motive, means, and value of recreation. Delving into both canonical masterpieces and hidden gems, this innovative volume stakes a claim for play as the crucial link between games and early modern theatre, and for the early modern theatre as a critical site for unraveling the continued cultural significance and performative efficacy of gameplay today.


2021 ◽  
Vol 12 ◽  
Author(s):  
Huan Xia ◽  
Suijuan Zhong ◽  
Yixiao Zhao ◽  
Boyang Ren ◽  
Zhongnan Wang ◽  
...  

Thymic blood vessels at the perivascular space (PVS) are the critical site for both homing of hematopoietic progenitor cells (HPCs) and egress of mature thymocytes. It has been intriguing how different opposite migrations can happen in the same place. A subset of specialized thymic portal endothelial cells (TPECs) associated with PVS has been identified to function as the entry site for HPCs. However, the cellular basis and mechanism underlying egress of mature thymocytes has not been well defined. In this study, using various conventional and conditional gene-deficient mouse models, we first confirmed the role of endothelial lymphotoxin beta receptor (LTβR) for thymic egress and ruled out the role of LTβR from epithelial cells or dendritic cells. In addition, we found that T cell-derived ligands lymphotoxin (LT) and LIGHT are required for thymic egress, suggesting a crosstalk between T cells and endothelial cells (ECs) for thymic egress control. Furthermore, immunofluorescence staining analysis interestingly showed that TPECs are also the exit site for mature thymocytes. Single-cell transcriptomic analysis of thymic endothelial cells suggested that TPECs are heterogeneous and can be further divided into two subsets depending on BST-1 expression level. Importantly, BST-1hi population is associated with thymic egressing thymocytes while BST-1lo/− population is associated with HPC settling. Thus, we have defined a LT/LIGHT-LTβR signaling–mediated cellular crosstalk regulating thymic egress and uncovered distinct subsets of TPECs controlling thymic homing and egress, respectively.


Author(s):  
Erana Hond-Flavell ◽  
◽  
Reremoana Theodore ◽  
Gareth Treharne ◽  
Aroaro Tamati ◽  
...  

Kaupapa Māori early years provision (KM-EYP) is often understood as a critical site for Māori cultural revitalisation, where a foundation for the educational success and lifelong wellbeing of tamariki Māori is laid. Given its importance, the Tangi te Kawekaweā study sought to identify and examine barriers and facilitators of whānau engagement in KM-EYP. Semi-structured interviews were conducted with individual whānau members (n = 19) and whānau groups (n = 5) enrolled in one centre for KM-EYP, and with expert informants (n = 10). This paper reports on the insights gained. Inductive thematic analysis identified barriers to engagement (e.g., historical trauma, whakamā, whānau disconnection) and facilitators of engagement (e.g., critical awareness, emotional and practical support, whānauranga). These findings have the potential to inform policy and practice to enhance whānau Māori engagement in the learning and development opportunities offered by KM-EYP and the early years sector more broadly.


2021 ◽  
pp. 152747642110200
Author(s):  
Sherry S. Yu

The Canadian Broadcasting Corporation’s Kim’s Convenience is the first Asian-led sitcom in Canadian broadcasting. This popular sitcom, lauded by both audiences and the television industry, joins the wave of minority-led production which started only recently in Canada, despite Canada’s pride in multiculturalism as one of its national characteristics. Emerging within Canada’s unique model of “multiculturalism within a bilingual framework,” Kim’s Convenience, with a story about a third-language Korean Canadian immigrant family, offers a critical site to understand how cultural diversity is communicated in Canadian television today. This study conducts a thematic analysis of Seasons One and Two with a special focus on interactions across cultures characterized by social categories such as ethnicity/race, gender, class, language, and sexuality.


2021 ◽  
Vol 29 ◽  
pp. 25
Author(s):  
Ángel De Jesus Gonzalez ◽  
Luz Burgos-López ◽  
Eric R. Felix ◽  
H. Kenny Nienhusser

This special issue examines the role of policy implementation in the community college context and the ways reforms are enacted to achieve or advance educational equity. In this introduction, we provide an overview of policy implementation, its current landscape within higher education, and the role it can and must serve for community colleges as a tool to advance equity efforts. The articles in this special issue provide a well-rounded overview of policy implementation efforts across various states and institutions. Authors examine promise programs, equity initiatives, articulation agreements, federally funded support programs, and race-conscious implementation. The community college context serves as a critical site of inquiry given that almost half of the undergraduate population is enrolled at a community college. Therefore, the following articles explore how to leverage policy implementation as a tool toward more equitable outcomes.


2021 ◽  
Vol 92 (1) ◽  
pp. 18-29
Author(s):  
Ivonne I. Vega‐Ruiz ◽  
José Alfredo Castillo‐Guerrero ◽  
Guillermo Fernández

2021 ◽  
Author(s):  
Abdelrahim Zoued ◽  
Hailong Zhang ◽  
Ting Zhang ◽  
Rachel T. Giorgio ◽  
Carole J. Kuehl ◽  
...  

SummaryThe microbial cell surface is a critical site of microbe-host interactions that often control infection outcomes. Here, using the infant rabbit model of cholera, which provides an abundant source of in vivo Vibrio cholerae cells and diarrheal fluid, we investigated the proteomic composition of this interface. Bulk diarrheal fluid proteomes revealed that cholera toxin accounts for the vast majority of the host proteins present during infection. We developed a surface biotinylation protocol to purify and quantify both bacterial and host proteins present on the surface of diarrheal fluid-derived V. cholerae. We found that SP-D, a toxin-dependent host protein that directly binds the V. cholerae surface, is a novel intestinal defense factor. Other V. cholerae-bound host proteins also bound distinct taxa of the murine intestinal microbiota. Proteomic investigation of the microbial surface-host interface should be a valuable tool for probing microbe-host interactions and their influence on homeostasis and infection.


Sign in / Sign up

Export Citation Format

Share Document