scholarly journals History, Evolution and Current State of Ovarian Tissue Auto-Transplantation with Cryopreserved Tissue: a Successful Translational Research Journey from 1999 to 2020

2020 ◽  
Vol 27 (4) ◽  
pp. 955-962 ◽  
Author(s):  
Loris Marin ◽  
Giuliano Bedoschi ◽  
Tai Kawahara ◽  
Kutluk H Oktay
Keyword(s):  
Translational Research ◽  
Ovarian Tissue ◽  
Current State ◽  
History Evolution

scholarly journals Lessons learned from developing and sustaining a community-research collaborative through translational research

2018 ◽  
Vol 2 (2) ◽  
pp. 79-85 ◽  
Author(s):  
Amy LeClair ◽  
Jean J. Lim ◽  
Carolyn Rubin
Keyword(s):  
Translational Research ◽  
Participatory Research ◽  
Community Based Participatory Research ◽  
Lessons Learned ◽  
Community Research ◽  
Structured Interviews ◽  
Community Based ◽  
Spheres Of Influence ◽  
Asian Populations ◽  
Current State

IntroductionThe goal of this project was to document the current state of a community-academic partnership, identifying early successes and lessons learned.MethodsWe employed qualitative methods, semi-structured interviews and document analysis, from 2 data sources to (1) show how the principles of community-based participatory research are enacted through the activities of Addressing Disparities in Asian Populations through Translational Research (ADAPT) and (2) elucidate the barriers and facilitators to adhering to those principles from the perspectives of the members themselves.ResultsIn addition to established community-based participatory research values, understanding individuals’ motivations for participation, the challenges aligning the priorities of community organizations and academic partners, and definitions of success are themes that emerged as key to the process of maintaining this partnership.ConclusionAs the emphasis on community-academic partnerships grows, there is potential for clinical and translational science awards to use community engagement to facilitate translational research beyond the traditional medical spheres of influence and to forge relationships with affected communities.

Female fertility preservation strategies: cryopreservation and ovarian tissuein vitroculture, current state of the art and future perspectives

Zygote ◽  
2016 ◽  
Vol 24 (5) ◽  
pp. 635-653 ◽  
Author(s):  
M.A. Filatov ◽  
Y.V. Khramova ◽  
M.V. Kiseleva ◽  
I.V. Malinova ◽  
E.V. Komarova ◽  
...  
Keyword(s):  
Fertility Preservation ◽  
State Of The Art ◽  
Ovarian Tissue ◽  
Female Fertility ◽  
Ovarian Tissue Cryopreservation ◽  
Future Perspectives ◽  
Current State ◽  
Female Fertility Preservation ◽  
Tissue Cryopreservation

SummaryIn the present review, the main strategies of female fertility preservation are covered. Procedures of fertility preservation are necessary for women who suffer from diseases whose treatment requires the use of aggressive therapies, such as chemotherapy and radiotherapy. These kinds of therapy negatively influence the health of gametes and their progenitors. The most commonly used method of female fertility preservation is ovarian tissue cryopreservation, followed by the retransplantation of thawed tissue. Another approach to female fertility preservation that has been actively developed lately is the ovarian tissuein vitroculture. The principal methods, advantages and drawbacks of these two strategies are discussed in this article.

scholarly journals Translational research in Uganda: linking basic science to bedside medicine in a resource limited setting

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Richard Kwizera ◽  
Emmanuel Mande ◽  
Denis Omali ◽  
Samuel Okurut ◽  
Sheila Nabweyambo ◽  
...  
Keyword(s):  
Translational Research ◽  
Clinical Care ◽  
Well Being ◽  
Research Capacity ◽  
Main Body ◽  
Medical Needs ◽  
Current State ◽  
Resource Limited ◽  
Barriers And Opportunities ◽  
Set Up

Abstract Background Translational research is a process of applying knowledge from basic biology and clinical trials to techniques and tools that address critical medical needs. Translational research is less explored in the Ugandan health system, yet, it is fundamental in enhancing human health and well-being. With the current high disease burden in Uganda, there are many opportunities for exploring, developing and utilising translational research. Main body In this article, we described the current state, barriers and opportunities for translational research in Uganda. We noted that translational research is underutilised and hindered by limited funding, collaborations, laboratory infrastructure, trained personnel, equipment and research diversity. However, with active collaborations and funding, it is possible to set up and develop thriving translational research in Uganda. Researchers need to leverage existing international collaborations to enhance translational research capacity development. Conclusion Expanding the integration of clinical and translational research in Uganda health care system will improve clinical care.

scholarly journals Should you be putting all your eggs into one basket? A look into the current state and future of ovarian tissue cryopreservation.

2015 ◽  
Vol 1 (2) ◽  
Author(s):  
Shakina Rauff ◽  
Zaraq Khan ◽  
Claus Yding Andersen
Keyword(s):  
Fertility Preservation ◽  
Ovarian Tissue ◽  
Mature Oocyte ◽  
Reproductive Capacity ◽  
Ovarian Tissue Cryopreservation ◽  
Embryo Cryopreservation ◽  
Social Motives ◽  
Current State ◽  
Medical Indications ◽  
Tissue Cryopreservation

 Ovarian tissue cryopreservation has its primary goal in fertility preservation for women diagnosed with a malignancy and who may be rendered infertile because of the potential gonadotoxic chemotherapy and/or radiotherapy involved in treating their disease. Unlike the standard and endorsed methods of fertility preservation like mature oocyte and embryo cryopreservation, ovarian tissue freezing not only conserves the reproductive capacity of the woman but additionally, maintains the steroidogenic competence of the ovary due to the fact that the frozen cortex contains numerous ovarian follicles – the functional unit of the ovary. Not every follicle is fated to aid procreation. In fact more than 99% are destined to end up in atresia, which may be viewed as an enormous waste of inherent resources. In light of this, there have been propositions to expand the scope of ovarian tissue cryopreservation and transplantation beyond its traditional purpose of fertility preservation for medical indications. Some of these ideas include utilizing cryopreserved ovarian tissue for induction of puberty, delaying the menopause and fertility preservation for social motives. Needless to say, these novel ideas will evoke questions, controversy and a plethora of criticism about the safety, superiority, cost-effectiveness, implications and necessity of these different utilities. In this article, we aim to explore some of the issues that shroud these new indications and discuss the advantages for and diatribe against these evolving suggestions.

scholarly journals Translational informatics: enabling high-throughput research paradigms

2009 ◽  
Vol 39 (3) ◽  
pp. 131-140 ◽  
Author(s):  
Philip R. O. Payne ◽  
Peter J. Embi ◽  
Chandan K. Sen
Keyword(s):  
Translational Research ◽  
High Throughput ◽  
Large Scale ◽  
Data Sets ◽  
Biomedical Data ◽  
Current State ◽  
Common Thread ◽  
Translational Informatics ◽  
Research Domains ◽  
Clinical And Translational Research

A common thread throughout the clinical and translational research domains is the need to collect, manage, integrate, analyze, and disseminate large-scale, heterogeneous biomedical data sets. However, well-established and broadly adopted theoretical and practical frameworks and models intended to address such needs are conspicuously absent in the published literature or other reputable knowledge sources. Instead, the development and execution of multidisciplinary, clinical, or translational studies are significantly limited by the propagation of “silos” of both data and expertise. Motivated by this fundamental challenge, we report upon the current state and evolution of biomedical informatics as it pertains to the conduct of high-throughput clinical and translational research and will present both a conceptual and practical framework for the design and execution of informatics-enabled studies. The objective of presenting such findings and constructs is to provide the clinical and translational research community with a common frame of reference for discussing and expanding upon such models and methodologies.

scholarly journals Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop

2016 ◽  
Vol 209 (5) ◽  
pp. 182-194 ◽  
Author(s):  
Pooja Hingorani ◽  
Katherine Janeway ◽  
Brian D. Crompton ◽  
Cigall Kadoch ◽  
Crystal L. Mackall ◽  
...  
Keyword(s):  
Translational Research ◽  
Current State ◽  
Pediatric Sarcoma ◽  
Research Workshop

scholarly journals piRNAs in Gastric Cancer: A New Approach Towards Translational Research

2020 ◽  
Vol 21 (6) ◽  
pp. 2126 ◽  
Author(s):  
Gleyce Fonseca Cabral ◽  
Jhully Azevedo dos Santos Pinheiro ◽  
Amanda Ferreira Vidal ◽  
Sidney Santos ◽  
Ândrea Ribeiro-dos-Santos
Keyword(s):  
Gastric Cancer ◽  
Translational Research ◽  
Cancer Progression ◽  
Genetic Alterations ◽  
Gastric Carcinogenesis ◽  
Current State ◽  
Small Regulatory Rnas ◽  
New Biomarkers ◽  
Late Stages

Background: Gastric cancer is currently the third leading cause of cancer-related deaths worldwide, usually diagnosed at late stages. The development of new biomarkers to improve its prevention and patient management is critical for disease control. piRNAs are small regulatory RNAs important for gene silencing mechanisms, mainly associated with the silencing of transposable elements. piRNA pathways may also be involved in gene regulation and the deregulation of piRNAs may be an important factor in carcinogenic processes. Thus, several studies suggest piRNAs as potential cancer biomarkers. Translational studies suggest that piRNAs may regulate key genes and pathways associated with gastric cancer progression, though there is no functional annotation in piRNA databases. The impacts of genetic variants in piRNA genes and their influence in gastric cancer development remains elusive, highlighting the gap in piRNA regulatory mechanisms knowledge. Here, we discuss the current state of understanding of piRNA-mediated regulation and piRNA functions and suggest that genetic alterations in piRNA genes may affect their functionality, thus, it may be associated with gastric carcinogenesis. Conclusions: In the era of precision medicine, investigations about genetic and epigenetic mechanisms are essential to further comprehend gastric carcinogenesis and the role of piRNAs as potential biomarkers for translational research.

scholarly journals The answer is 17 years, what is the question: understanding time lags in translational research

2011 ◽  
Vol 104 (12) ◽  
pp. 510-520 ◽  
Author(s):  
Zoë Slote Morris ◽  
Steven Wooding ◽  
Jonathan Grant
Keyword(s):  
Knowledge Transfer ◽  
Translational Research ◽  
Health Research ◽  
Investment Decisions ◽  
Health Interventions ◽  
Research Translation ◽  
Time Lags ◽  
Translation Process ◽  
Time Points ◽  
Current State

This study aimed to review the literature describing and quantifying time lags in the health research translation process. Papers were included in the review if they quantified time lags in the development of health interventions. The study identified 23 papers. Few were comparable as different studies use different measures, of different things, at different time points. We concluded that the current state of knowledge of time lags is of limited use to those responsible for R&D and knowledge transfer who face difficulties in knowing what they should or can do to reduce time lags. This effectively ‘blindfolds’ investment decisions and risks wasting effort. The study concludes that understanding lags first requires agreeing models, definitions and measures, which can be applied in practice. A second task would be to develop a process by which to gather these data.

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