Epidermal growth factor selectively enhances NMDA receptor-mediated increase of intracellular Ca2+ concentration in rat hippocampal neurons

1992 ◽  
Vol 587 (1) ◽  
pp. 102-108 ◽  
Author(s):  
Kazuho Abe ◽  
Hiroshi Saito
Keyword(s):  
Nmda Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hippocampal Neurons ◽  
Epidermal Growth

scholarly journals Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth

2004 ◽  
Vol 15 (5) ◽  
pp. 2093-2104 ◽  
Author(s):  
Yaojiong Wu ◽  
Wang Sheng ◽  
Liwen Chen ◽  
Haiheng Dong ◽  
Vivian Lee ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Neurite Outgrowth ◽  
Neuronal Differentiation ◽  
Hippocampal Neurons ◽  
Neuronal Development ◽  
Growth Factor Receptor ◽  
Adult Brain ◽  
Epidermal Growth

The chondroitin sulfate proteoglycan versican is one of the major extracellular components in the developing and adult brain. Here, we show that isoforms of versican play different roles in neuronal differentiation and neurite outgrowth. Expression of versican V1 isoform in PC12 cells induced complete differentiation, whereas expression of V2 induced an aborted differentiation accompanied by apoptosis. V1 promoted neurite outgrowth of hippocampal neurons, but V2 failed to do so. V1 transfection enhanced expression of epidermal growth factor receptor and integrins, and facilitated sustained extracellular signal-regulated kinase/MAPK phosphorylation. Blockade of the epidermal growth factor receptor, β1 integrin, or Src significantly inhibited neuronal differentiation. Finally, we demonstrated that versican V1 isoform also promoted differentiation of neural stem cells into neurons. Our results have implications for understanding how versican regulates neuronal development, function, and repair.

Epidermal growth factor enemas are effective in the treatment of left-sided ulcarative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A11-A12 ◽  
Author(s):  
A SINHA ◽  
J NIGHTINGALE ◽  
K WEST ◽  
R PLAYFORD
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epidermal Growth
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