Systematic studies on toxic components in industrial wastes with reference to the tolerance of aquatic lives. II. On acute toxic components in digested waste from ammonium-base semichemical pulp mills. III. Toxic components in water extract liquor from bark. (In Japanese: English abstracts)

1966 ◽  
Vol 13 (5) ◽  
pp. 1098
2021 ◽  
Vol 12 ◽  
Author(s):  
Min Zhang ◽  
Meng Gao ◽  
Shanshan Wu ◽  
Lifen Zhou ◽  
Lan Cao ◽  
...  

In recent years, drug-induced liver injury (DILI) has become an important issue of public health. Euodiae Fructus (EF) is a commonly used herb with mild toxicity in clinic, and large doses of EF can cause significant liver damage. Licorice processing might reduce the hepatotoxicity of CEF (crude EF), but up to now, studies on the hepatotoxicity of EF have been hardly reported, let alone its material basis and mechanism of detoxification by licorice processing. This work firstly established a stomach excess-cold syndrome animal model induced by intragastric administration of cold Zhimu (Anemarrhena asphodeloides Bge). Secondly, multiple approaches and indexes were used to evaluate the hepatotoxicity of the drugs in the rats including general behavior, biochemical analysis, protein expressions, and histopathological examination. Thirdly, the hepatotoxicity of three doses of three CEF and LPEF (licorice-processed EF) extracts was systematically investigated, and the hepatotoxicity differences were analyzed and compared comprehensively among the three extracts, three doses, and CEF and LPEF. Finally, the connotation of detoxification of EF by licorice processing was preliminarily discussed according to the changes in toxic components after processing, toxicological characteristics, and TCM (traditional Chinese medicine) theory. All extracts of EF were found to have dose-dependent hepatotoxicity, and the toxicity was in the descending order of water extract, ethanol extract, and volatile oil. The hepatotoxic mechanism of EF may be related to peroxidation damage, inflammatory factor, and mitochondrial injury. The CEF hepatotoxicity can be significantly reduced by licorice processing. EF should be safe for short-term use at pharmacopeial dose under the guidance of the TCM theory. The detoxification mechanism is probably related to the reduction of toxic components and antagonistic action of licorice.


Author(s):  
Hans Tammemagi

We are a wasteful lot on planet Earth. We do not mean to be, but this is an inherent and unavoidable feature of human society. The processes of living, eating, working, playing, and dying all utilize consumer products whose production and use generate wastes. Every candy bar has a wrapper; every apple has a core. It is almost impossible to think of a process that does not create some waste. There is sawdust from cutting lumber, metal shavings from drilling and soldering circuit boards, sludges from chemical processes, leftover food from restaurants, waste paper by the ton from environmental hearings and other legal proceedings, dirty diapers, and other household garbage. Societal wastes range from the refuse produced by every family to highly toxic industrial wastes from the production of specialized goods such as electronics, computers, cars, petrochemicals, and plastics. Virtually every aspect of our daily lives generates waste. Waste cannot be avoided. But what happens to all this waste? Some of it is recycled. During the past ten years there has been a growing realization that our globe is finite in its resources, and that the environment is under considerable stress and is being quietly but relentlessly despoiled. In response, streetside “blue box” and other recycling programs have sprouted. Approximately 20% of municipal waste in North America is currently being recycled: metal cans are going back to smelters, paper back to pulp mills, and glass and plastic to factories to be turned into new products. Recycling programs are still expanding, and it is anticipated that in the future as much as 50%, and perhaps even more, of all household and commercial waste will be recycled. Some of the waste is incinerated. When this is accompanied by generation of electricity or useful steam or heat, it can be viewed as a form of recycling—the conversion of waste to energy, a very useful product. It also helps preserve precious nonrenewable resources such as gas, oil, and coal. Many people, however, are concerned about the emissions that are released into the air and the ash that is produced. About 18% of municipal solid waste in the United States is currently being incinerated, with about 75% of the incinerators generating energy (EPA, 1994).


2005 ◽  
Vol 62 (3) ◽  
pp. 286-290 ◽  
Author(s):  
Ademir Sérgio Ferreira Araújo ◽  
Regina Teresa Rosim Monteiro

Composting of industrial wastes is increasing because of recycling requirements set on organic wastes. The evaluation of toxicity of these wastes by biological testing is therefore extremely important for screening the suitability of waste for land application. The toxicity of a textile sludge compost was investigated using seed germination and plant growth bioassays using soybean and wheat. Compost samples were mixed with water (seed germination bioassay) or nutrient solution (plant growth bioassay) at concentrations of 0, 19, 38, 76 and 152 g L-1. No negative effects were observed after five days of compost water-extract in relation to soybean and wheat seed germination. After fifteen days, under a hydroponics system, plant growth had harmful effects of the compost at concentrations above 38 g L-1. Textile sludge compost presented great phytotoxicity under hydroponics condition and the soybean and wheat were sensitive for evaluation of organic wastes in plant growth bioassays.


Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
YC Oh ◽  
YH Jeong ◽  
WK Cho ◽  
SJ Lee ◽  
JY Ma

Sign in / Sign up

Export Citation Format

Share Document