Evidence for involvement of ornithine decarboxylase in transforming growth factor alfa-stimulated gastric epithelial cell proliferation

1995 ◽  
Vol 108 (4) ◽  
pp. A741
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Epithelial Cell ◽  
Ornithine Decarboxylase ◽  
Transforming Growth Factor ◽  
Gastric Epithelial Cell ◽  
Epithelial Cell Proliferation

scholarly journals Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 ◽  
Vol 11 (3) ◽  
pp. 1185-1194 ◽  
Author(s):  
P H Howe ◽  
G Draetta ◽  
E B Leof
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Epithelial Cell ◽  
Transforming Growth Factor Beta ◽  
Kinase Activity ◽  
Transforming Growth Factor ◽  
S Phase ◽  
Epithelial Cell Proliferation ◽  
Tgf Beta ◽  
Growth Factor Beta

Transforming growth factor beta 1 (TGF beta 1) is a potent inhibitor of epithelial cell proliferation. We present data which indicate that epithelial cell proliferation is inhibited when TGF beta 1 is added throughout the prereplicative G1 phase. Cultures become reversibly blocked in late G1 at the G1/S-phase boundary. The inhibitory effects of TGF beta 1 on cell growth occur in the presence of the RNA synthesis inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Associated with this inhibitory effect is a decrease in the phosphorylation and histone H1 kinase activity of the p34cdc2 protein kinase. These data suggest that TGF beta 1 growth inhibition in epithelial cells involves the regulation of p34cdc2 activity at the G1/S transition.

Dexamethasone inhibits basic fibroblast growth factor-stimulated gastric epithelial cell proliferation

2008 ◽  
Vol 76 (7) ◽  
pp. 841-849 ◽  
Author(s):  
Jiing-Chyuan Luo ◽  
Hsiao-Yi Lin ◽  
Ching-Liang Lu ◽  
Lung-Yao Wang ◽  
Full-Young Chang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Epithelial Cell ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Gastric Epithelial Cell ◽  
Fibroblast Growth ◽  
Epithelial Cell Proliferation
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