Relationship of fasting blood glucose to prevalence of ECG abnormalities and 10 yr risk of mortality from cardiovascular diseases in men born in 1914: From the Glostrup population studies

1979 ◽  
Vol 32 (11-12) ◽  
pp. 699-707 ◽  
Author(s):  
Marianne Schroll ◽  
Leif Hagerup
2017 ◽  
Vol 12 (2) ◽  
pp. 325-332 ◽  
Author(s):  
Junxiang Luo ◽  
Yongming Qu ◽  
Qianyi Zhang ◽  
Annette M. Chang ◽  
Scott J. Jacober

Background: The association of glucose variability (GV) with other glycemic measures is emerging as a topic of interest. The aim of this analysis is to study the correlation between GV and measures of glycemic control, such as glycated hemoglobin (HbA1c) and daily mean glucose (DMG). Methods: Data from 5 phase 3 trials were pooled into 3 analysis groups: type 2 diabetes (T2D) treated with basal insulin only, T2D treated with basal-bolus therapy, and type 1 diabetes (T1D). A generalized boosted model was used post hoc to assess the relationship of the following variables with glycemic control parameters (HbA1c and DMG): within-day GV, between-day GV (calculated using self-monitored blood glucose and fasting blood glucose [FBG]), hypoglycemia rate, and certain baseline characteristics. Results: Within-day GV (calculated using standard deviation [SD]) was found to have a significant influence on endpoints HbA1c and DMG in all 3 patient groups. Between-day GV from FBG (calculated using SD), within-day GV (calculated using coefficient of variation), and hypoglycemia rate were found to significantly influence the endpoint HbA1c in the T2D basal-only group. Conclusions: Lower within-day GV was significantly associated with improvement in DMG and HbA1c. This finding suggests that GV could be a marker in the early phases of new antihyperglycemic therapy development for predicting clinical outcomes in terms of HbA1c and DMG.


2020 ◽  
Author(s):  
Bin Zhu ◽  
Chunguo Jiang ◽  
Xiaokai Feng ◽  
Yanfei Zheng ◽  
Jie Yang ◽  
...  

Abstract Background Coronavirus disease-19 (COVID-19) has spread rapidly, with a growing number of cases confirmed around the world. This study explores the relationship of fasting blood glucose (FBG) at admission with mortality. Methods In this retrospective, single-center study, we analyzed the clinical characteristics of confirmed cases of COVID-19 in Wu Han from 29 January 2020 to 23 February 2020. Cox proportional hazard regression analysis was performed to evaluate the relationship between FBG and mortality. Results A total of 107 patients were enrolled in our study. The average age was 59.49 ± 13.33 and the FBG at admission was 7.35 ± 3.13 mmol/L. There were 16 people died of COVID-19 with an average age 68.1 ± 9.5 and the FBG was 8.94 ± 4.76 mmol/L. Regression analysis showed that there were significant association between FBG and death (HR = 1.13, 95%CI: 1.02-1.24). After adjusting for covariables, the significance still exists. In addition, our result showed that FBG > 7.0 mmol/L or diabetic mellitus can significantly increase mortality after adjusting for the age and gender. Conclusions This study suggests that FBG at admission is an effective and reliable indicator for disease prognosis in COVID-19 patients.


2010 ◽  
Vol 4 (1) ◽  
pp. 21-25
Author(s):  
Indrajit Prasad ◽  
Zafar Ahmed Latif ◽  
Tofail Ahmed ◽  
Faruque Pathan ◽  
SM Ashrafuzzaman ◽  
...  

This study was conducted to assess the presence of microalbuminuria in newly detected diabetesmellitus (DM) cases in a small group of Bangladeshi population attending BIRDEM out patientdepartment and to find out the relationship (if any) of microalbuminuria with different clinical andbiochemical parameters. Out of 110 DM cases, 10 (9.1%) were found to have microalbuminuria.Blood pressure, both systolic (r=0.190) and diastolic (r = 0.30) had significant positive correlationwith urinary albumin. There was no association of microalbuminuria with waist circumference,waist to hip ratio, serum triglycerides, HDL cholesterol, fasting blood glucose, age, sex, weight,height or BMI. This suggests that all newly detected diabetes mellitus should be screened for raisedblood pressure and if found positive be given the same importance as blood glucose. They should betreated meticulously to revert or prevent microalbuminuria and thus prevent complications.Ibrahim Med. Coll. J. 2010; 4(1): 21-25DOI: 10.3329/imcj.v4i1.5931


2020 ◽  
Author(s):  
Bin Zhu ◽  
Chunguo Jiang ◽  
Xiaokai Feng ◽  
Yanfei Zheng ◽  
Jie Yang ◽  
...  

Abstract Background: Coronavirus disease-19 (COVID-19) has spread rapidly, with a growing number of cases confirmed around the world. This study explores the relationship of fasting blood glucose (FBG) at admission with mortality.Methods: In this retrospective, single-center study, we analyzed the clinical characteristics of confirmed cases of COVID-19 in Wu Han from 29 January 2020 to 23 February 2020. Cox proportional hazard regression analysis was performed to evaluate the relationship between FBG and mortality.Results: A total of 107 patients were enrolled in our study. The average age was 59.49 ± 13.33 and the FBG at admission was 7.35 ± 3.13 mmol/L. There were 16 people died of COVID-19 with an average age 68.1 ± 9.5 and the FBG was 8.94 ± 4.76 mmol/L. Regression analysis showed that there were significant association between FBG and death (HR = 1.13, 95%CI: 1.02-1.24). After adjusting for covariables, the significance still exists. In addition, our result showed that FBG > 7.0 mmol/L or diabetic mellitus can significantly increase mortality after adjusting for the age and gender.Conclusions: This study suggests that FBG at admission is an effective and reliable indicator for disease prognosis in COVID-19 patients.


2015 ◽  
Vol 17 (5) ◽  
pp. 307-310 ◽  
Author(s):  
Alysa J. Sampson Perrin ◽  
Russell C. Guzzetta ◽  
Kellee M. Miller ◽  
Nicole C. Foster ◽  
Anna Lee ◽  
...  

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p<0.05) and group IV (11.34 ±3.67, p<0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p<0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.


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