Computerized data analysis in cellular immunology. Enhancement and suppression of immune responses

1988 ◽  
Vol 112 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Alessandro Sette ◽  
Luciano Adorini ◽  
Camillo Mancini ◽  
Ettore Marubini ◽  
Gino Doria
Keyword(s):  
Data Analysis ◽  
Immune Responses ◽  
Cellular Immunology

An appraisal of survival strategies

Parasitology ◽  
1984 ◽  
Vol 88 (4) ◽  
pp. 575-577 ◽  
Author(s):  
N. A. Mitchison
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Survival Strategies ◽  
Host Immune System ◽  
Cellular Immunology ◽  
Host Immune Responses ◽  
Host Defence System ◽  
Bio Engineering

Only a few years ago parasite immunology looked an unattractive subject better left to the dogged specialists. Parasites and hosts had been playing chess together for a million years, and there seemed little prospect of perturbing matters in favour of the host immune system. All that has changed, for three reasons. Firstly, we have learned how to grow at least some parasites in vitro, and prospects of doing so with others are encouraging. Secondly, progress in cellular immunology has revealed the sort of loopholes in the host defence system which parasites are likely to exploit: we are learning the questions which matter about parasites as antigens. Thirdly, and most importantly, molecular genetics is being brought to bear on parasites: we can now see a real, though long-term, prospect of manufacturing practicable vaccines through bio-engineering, and more immediately it gives us the tools needed to probe the host immune responses in the form of cloned antigens.

scholarly journals Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques

2006 ◽  
Vol 22 (14) ◽  
pp. 1760-1766 ◽  
Author(s):  
Suman Sundaresh ◽  
Denise L. Doolan ◽  
Siddiqua Hirst ◽  
Yunxiang Mu ◽  
Berkay Unal ◽  
...  
Keyword(s):  
Data Analysis ◽  
Immune Responses ◽  
Dna Microarray ◽  
Microarray Data ◽  
Protein Microarrays ◽  
Microarray Data Analysis ◽  
Analysis Techniques ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Dna Microarray Data

scholarly journals Trichuris murisresearch revisited: a journey through time

Parasitology ◽  
2013 ◽  
Vol 140 (11) ◽  
pp. 1325-1339 ◽  
Author(s):  
REBECCA J. M. HURST ◽  
KATHRYN J. ELSE
Keyword(s):  
Immune Responses ◽  
Research Papers ◽  
Trichuris Muris ◽  
Cellular Immunology ◽  
Host Parasite Interactions ◽  
History Of ◽  
Parasite Biology ◽  
Definition Of ◽  
Host Parasite

SUMMARYThe mouse whipwormTrichuris murishas long been used as a tractable model of human Trichuriasis. Here we look back at the history ofT. murisresearch; from the definition of the species and determination of its life cycle, through to the complex immune responses that we study today. We highlight the key research papers that have developed our understanding of immune responses to this parasite, and reflect on how original concepts have been transformed, as our knowledge of immunology has grown. Although we have a good understanding of host–parasite interactions in the context of the underlying cellular immunology, there are still many aspects of the biology of theTrichurisparasite that remain undefined. We predict that advances in parasite biology will be key in the future development of new and improved treatments for Trichuriasis.

Niels Kaj Jerne. 23 December 1911—7 October 1994.

1997 ◽  
Vol 43 ◽  
pp. 237-251
Author(s):  
Brigitte A. Askonas ◽  
James G. Howard
Keyword(s):  
Immune Responses ◽  
Lymphoid Cells ◽  
Immune Recognition ◽  
Research Career ◽  
Cellular Immunology ◽  
Analytical Thinking ◽  
Experimental Approaches ◽  
Basic Biology ◽  
Late Starter ◽  
Antibody Secreting Cells

Niels Jerne was unquestionably one of the most distinguished immunologists of the present century. Although a relatively late starter—he was approaching 40 before he seriously embarked on a research career—he soon made a major impact that altered the direction of attempts to understand the biology of immune responses. For more than 30 years Niels was preoccupied with the mechanism of specific immune recognition by lymphoid cells, its generation and regulation, and the expression of a diverse repertoire. His analytical thinking is apparent in deeply considered papers, which show a remarkable continuity in the development of ideas from beginning to end of an unconventional career. Niels was predominantly a theoretician who probed deeply into the basic biology of recognition by identifying major questions, which he always tackled with quantitative logic. This orientation also led to the delineation of the first quantitative assay for antibody–secreting cells (plaque–forming cells), which had an enormous impact on the research of others in cellular immunology. The powerful influence he exerted on the thinking, objectives and experimental approaches of his contemporaries and young associates is one measure of his greatness. He created and directed for 10 years the unique Basel Institute for Immunology, entirely funded by Hoffmann LaRoche. He received many honours culminating in the award of the Nobel Prize for Physiology or Medicine in 1984.

Microchemical imaging in biomedical research

1992 ◽  
Vol 50 (2) ◽  
pp. 1118-1119
Author(s):  
P. Ingram
Keyword(s):  
Data Analysis ◽  
Electron Probe ◽  
The Other ◽  
X Ray ◽  
Cell Element ◽  
Physiological Information ◽  
Functional States ◽  
Elemental Maps ◽  
Electron Energy Loss ◽  
Secondary Ion

It is well established that unique physiological information can be obtained by rapidly freezing cells in various functional states and analyzing the cell element content and distribution by electron probe x-ray microanalysis. (The other techniques of microanalysis that are amenable to imaging, such as electron energy loss spectroscopy, secondary ion mass spectroscopy, particle induced x-ray emission etc., are not addressed in this tutorial.) However, the usual processes of data acquisition are labor intensive and lengthy, requiring that x-ray counts be collected from individually selected regions of each cell in question and that data analysis be performed subsequent to data collection. A judicious combination of quantitative elemental maps and static raster probes adds not only an additional overall perception of what is occurring during a particular biological manipulation or event, but substantially increases data productivity. Recent advances in microcomputer instrumentation and software have made readily feasible the acquisition and processing of digital quantitative x-ray maps of one to several cells.

Perceptions of a Collaborative Professional Learning Program: Seeing the “Bigger Picture”

2020 ◽  
Vol 5 (1) ◽  
pp. 290-303
Author(s):  
P. Charlie Buckley ◽  
Kimberly A. Murza ◽  
Tami Cassel
Keyword(s):  
Data Analysis ◽  
Professional Learning ◽  
Social Communication ◽  
Special Educators ◽  
Service Providers ◽  
Integrative Approach ◽  
Theory Approach ◽  
Learning Program ◽  
Speech Language Pathologists ◽  
Related Service

Purpose The purpose of this study was to explore the perceptions of special education practitioners (i.e., speech-language pathologists, special educators, para-educators, and other related service providers) on their role as communication partners after participation in the Social Communication and Engagement Triad (Buckley et al., 2015 ) yearlong professional learning program. Method A qualitative approach using interviews and purposeful sampling was used. A total of 22 participants who completed participation in either Year 1 or Year 2 of the program were interviewed. Participants were speech-language pathologists, special educators, para-educators, and other related service providers. Using a grounded theory approach (Glaser & Strauss, 1967 ) to data analysis, open, axial, and selective coding procedures were followed. Results Three themes emerged from the data analysis and included engagement as the goal, role as a communication partner, and importance of collaboration. Conclusions Findings supported the notion that educators see the value of an integrative approach to service delivery, supporting students' social communication and engagement across the school day but also recognizing the challenges they face in making this a reality.

Communicative Performance of Adolescents with Severe Speech Impairment

1989 ◽  
Vol 54 (3) ◽  
pp. 403-421 ◽  
Author(s):  
Beth M. Dalton ◽  
Jan L. Bedrosian
Keyword(s):  
Data Analysis ◽  
Peer Interactions ◽  
Consistent Pattern ◽  
Clinical Implications ◽  
Speech Impairment ◽  
Communication Mode ◽  
Mode Function ◽  
Communicative Performance ◽  
Therapy Room ◽  
Communication Board

The communicative performance of 4 preoperational-level adolescents, using limited speech, gestures, and communication board techniques, was examined in a two-part investigation. In Part 1, each subject participated in an academic interaction with a teacher in a therapy room. Data were transcribed and coded for communication mode, function, and role. Two subjects were found to predominantly use the speech mode, while the remaining 2 predominantly used board and one other mode. The majority of productions consisted of responses to requests, and the initiator role was infrequently occupied. These findings were similar to those reported in previous investigations conducted in classroom settings. In Part 2, another examination of the communicative performance of these subjects was conducted in spontaneous interactions involving speaking and nonspeaking peers in a therapy room. Using the same data analysis procedures, gesture and speech modes predominated for 3 of the subjects in the nonspeaking peer interactions. The remaining subject exhibited minimal interaction. No consistent pattern of mode usage was exhibited across the speaking peer interactions. In the nonspeaking peer interactions, requests predominated. In contrast, a variety of communication functions was exhibited in the speaking peer interactions. Both the initiator and the maintainer roles were occupied in the majority of interactions. Pertinent variables and clinical implications are discussed.

Specific humoral immune responses in 12 cases of food sensitization to sesame seed

1997 ◽  
Vol 27 (11) ◽  
pp. 1285-1291 ◽  
Author(s):  
M. N. KOLOPP-SARDA ◽  
D. A. MONERET-VAUTRIN ◽  
B. GOBERT ◽  
G. KANNY ◽  
M. BRODSCHII ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sesame Seed ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Food Sensitization
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