Abrusoside e, a further sweet-tasting cycloartane glycoside from the leaves of Abrus precatorius

1996 ◽  
Vol 41 (5) ◽  
pp. 1381-1383 ◽  
Author(s):  
Edward J. Kennelly ◽  
Lining Cai ◽  
Nam-Cheol Kim ◽  
A. Douglas Kinghorn
2021 ◽  
Vol 2 ◽  
Author(s):  
Rajender Kumar Sharma

Abstract Seeds of Abrus precatorius L. (Fabaceae) were used as weight measure by Indigenous people. Where, the seeds were referred as Ratti; a traditional Indian unit of mass measurement. Seed weight fluctuates depending upon age, moisture, storage-period/conditions. Therefore, use of seeds as a weighing unit become dubious and need to be validated. For this purpose, seeds of A. precatorious were subjected to different moisture conditions and periodically monitored. Surprisingly, there was no change in seed weight was observed, indicating the impermeability of seed coat. The later was confirmed by scarification of seed coat which resulted in 53% increase in seed weight against 0% in control. Further, presence of a potent toxin (abrin) in the seed coat protects it from pests and microbes, and contributes to the maintenance of impermeability for longer period of time. The data validates the use of A. precatorious seeds as a weighing unit (ratti) by the indigenous people and discussed.


1974 ◽  
Vol 249 (3) ◽  
pp. 803-810 ◽  
Author(s):  
Sjur Olsnes ◽  
Erling Saltvedt ◽  
Alexander Pihl

2007 ◽  
Vol 45 (1) ◽  
pp. 77-79 ◽  
Author(s):  
Vaibhav Sahni ◽  
Satish K. Agarwal ◽  
Narinder P. Singh ◽  
Sunandan Sikdar

Toxicon ◽  
1969 ◽  
Vol 7 (3) ◽  
pp. 211-216 ◽  
Author(s):  
S.K. Niyogi ◽  
F. Rieders

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Emeka E. Okoro ◽  
Omolaja R. Osoniyi ◽  
Almas Jabeen ◽  
Sidrah Shams ◽  
M. I. Choudhary ◽  
...  

Abstract Background Abrus precatorius possesses various therapeutic properties including anticancer potentials. This study evaluated the anti-proliferative activities of fractions of methanol root extract of A. precatorius on breast and cervical cancer cells and their immunomodulatory effect. Phytochemical screening was done by FTIR and GCMS. In vitro anti-proliferative effect was evaluated on human breast cancer (AU565) and cervical cancer (HeLa) cells and on murine fibroblast (NIH 3 T3) cells. Antioxidant activity was performed via DPPH radical scavenging assay. The immunomodulatory potential of fractions was evaluated by inhibition of phagocytes oxidative burst (ROS), Nitric oxide (NO) and proinflammatory cytokine TNF-α. Results A. precatorius fractions showed different chemical groups and were somewhat selective in antiproliferative activity against studied cancer cells. Ethyl acetate fraction showed the most significant antiproliferative activity with IC50 values of 18.10 μg/mL and 11.89 μg/mL against AU565 and HeLa cells respectively. Hexane fraction significantly (p < 0.05) inhibited HeLa cells (IC50 18.24 ± 0.16 μg/mL), whereas aqueous fraction showed mild inhibition (IC50 46.46 ± 0.14 μg/mL) on AU565 cell proliferation. All fractions showed no cytotoxicity against NIH-3 T3 murine fibroblast normal cells. All fractions showed potent and significant (p < 0.001) DPPH radical scavenging activity as well as suppressed phagocytic oxidative burst. Hexane (< 1 μg/mL), ethyl acetate (< 1 μg/mL), and butanol (5.74 μg/mL) fractions potently inhibited the cytokine TNF- α, hexane (< 1 μg/mL) and ethyl acetate (< 1 μg/mL) fractions also potently inhibited NO. Conclusions The antiproliferative activities and suppressive effect on the phagocytic oxidative burst, NO and proinflammatory cytokine might be due to the synergistic actions of bioactive compounds especially flavonoids present in the assayed fractions and therefore, suggest chemotherapeutic use of A. precatorius in cancer treatment.


2017 ◽  
Vol 2 (2) ◽  
pp. 239
Author(s):  
Ratih Dyah Pertiwi ◽  
Joni Kristanto ◽  
Graha Ayu Praptiwi

One of plants used by Indonesian people as a traditional medicine is saga plant (Abrus precatorius L.). This plant has medicinal properties as medication for thrush, cough and laryngitis. Chemical constituents contained in sage leaves which work as antibacterial are flavonoid and saponin. This study aims to determine the optimal concentration of saga leaves extract which can be formulated in a gel dosage form with qualified physical evaluation and has antibacterial activity against Staphylococcus aureus. Saga leaves extract is prepared by maceration method using ethanol 70% as solvent, and then the extract obtained is preliminarily tested to see its antibacterial activity against Staphylococcus aureus with agar diffusion method. Gel formulation for thrush is made with dispersion method in three formulas with variants of active substance concentration that is FI (1%), FII (3%) and FIII (5%). Gel preparation antibacterial activity test is conducted with agar diffusion method as a plate cylinder. Based on this research, it was found that the extract of saga leaves which is positively made is efficacious as antibacterial and can be formulated into a gel preparation for thrush with optimal concentration in F III (5%), this is indicated by widest diameter of the inhibition area against Staphylococus aureus bacteria


Science ◽  
1969 ◽  
Vol 166 (3901) ◽  
pp. 44-44
Author(s):  
R. S. Chakravarthy
Keyword(s):  

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