The effect of zinc(II) and chromium(III) on carbon tetrachloride hepatotoxicity: Evidence against a free radical scavenging role for induced metallothionein.

1993 ◽  
Vol 51 (1-2) ◽  
pp. 408
Author(s):  
P.M. Hanna ◽  
M.B. Kadiiska ◽  
S.J. Jordan ◽  
R.P. Mason
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Radical Scavenging ◽  
Free Radical Scavenging

scholarly journals Preliminary Free Radical Scavenging, Brine Shrimp Lethality, Antimicrobial and Thrombolytic Activities of Aganosma dichotoma (Roth) K. Schum.

2015 ◽  
Vol 17 (2) ◽  
pp. 177-181
Author(s):  
Sanjoy Chandra Dey ◽  
Mohammd Firoz Khan ◽  
Mohammad S Rahman ◽  
Mohammad A Rashid
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Brine Shrimp ◽  
Soluble Fraction ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Pharmaceutical Journal ◽  
Free Radical Scavenging ◽  
Clot Lysis ◽  
Brine Shrimp Lethality

Bangladesh is a good repository of natural products. Numerous plants are available to facilitate the traditional treatments. Proper scientific evaluations are essential to explore the plant derived drugs. With this view, the crude methanol extract of leaves of Aganosma dichotoma (Roth) K. Schum. and its Kupchan fractions were screened for free radical scavenging, brine shrimp lethality, antimicrobial and thrombolytic activities. Among all extractives, the chloroform soluble fraction demonstrated the highest free radical scavenging activity with IC50 value 18.21 ?g/ml. Moreover, the chloroform soluble fraction showed significant brine shrimp lethality having LC50 value of 3.98 ?g/ml. On the other hand, the petroleum ether, carbon tetrachloride and chloroform soluble materials revealed mild to moderate antimicrobial activity with the zone of inhibition ranging from 7 to 14 mm. In the thrombolytic assay, the carbon tetrachloride soluble partitionate showed the highest clot lysis (30.48%). This is the first report of the comprehensive investigations of different extractives of A. dichotoma for the abovementioned bioassays. DOI: http://dx.doi.org/10.3329/bpj.v17i2.22337 Bangladesh Pharmaceutical Journal 17(2): 177-181, 2014

scholarly journals Antimicrobial, Cytotoxic, Thrombolytic and Antioxidant Activities of Syzygium fruticosum (Roxb.) DC.

2015 ◽  
Vol 17 (1) ◽  
pp. 51-54
Author(s):  
Somaia Haque Chadni ◽  
Abdullah Al Hasan ◽  
ATM Zafrul Azam
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Soluble Fraction ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Zone Of Inhibition ◽  
Aqueous Fraction

The crude methanol extracts of the bark and leaves of Syzygium fruticosum (Roxb.) DC. were partitioned with petroleum ether, carbon tetrachloride, chloroform and water for biological investigation. In the brine shrimp lethality bioassay, carbon tetrachloride soluble fraction of leaf extract (LCTF) showed significant lethality having the LC50 value 0.65 ?g/ml. In free radical scavenging activity screening (DPPH assay), chloroform fraction of methanolic extract of bark of S. fruticosum showed the highest free radical scavenging activity with IC50 value 20.01 ?g/ml. In the microbiological investigation, only chloroform soluble fraction of bark (BCF) and aqueous fraction of bark (BAF) showed mild antimicrobial activity with zone of inhibition ranging from 7 to 14 mm as compared to standard ciprofloxacin (zone of inhibition of 50 mm). In the study for thrombolytic property, different extracts of S. fruticosum revealed varying degrees of thrombolytic activity ranging from 33.46% to 62.51%. DOI: http://dx.doi.org/10.3329/bpj.v17i1.22315 Bangladesh Pharmaceutical Journal 17(1): 51-54, 2014

Amelioration of Experimental Hepatotoxicity in Rats by Portulaca oleracea Linn. from Kashmir Himalaya

2021 ◽  
Vol 24 ◽  
Author(s):  
Mohd Akbar Dar ◽  
Prince Ahad Mir ◽  
Mubashir Hussain Masoodi ◽  
Ali S. Alqahtani ◽  
Nasir A. Siddiqui ◽  
...  
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Liver Diseases ◽  
Methanol Extract ◽  
Liver Toxicity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Portulaca Oleracea ◽  
Serum Glutamic Oxaloacetic Transaminase

Background: Traditionally, Portulaca oleracea Linn for treating abscesses, dysentery, and also for the treatment of liver diseases. Recent studies have reported its efficacy as neuroprotective, analgesic and anti-inflammatory, a bronchodilator, anticancer, antioxidant, wound healing, besides other important pharmacological actions. Aim and Objective: For curing liver diseases, Chinese use juice from the fresh leaves of Portulaca oleracea Linn, hence to prove this claim an in-vivo hepatoprotective study of extracts from Portulaca oleracea Linn. against carbon tetrachloride hepatotoxic rats. Methods: The in-vitro antioxidant activity by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and hepatoprotective activity of extracts of Portulaca oleracea Linn. was assessed against the carbon tetrachloride-induced toxicity rat model. Results: The extracts of Portulaca oleracea Linn produced concentration-dependent percentage inhibition of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical and most significantly by methanol extract. Among the extracts, methanol extract showed a significant decrease in Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) levels, and a significant increase in total protein (TP) levels against carbon tetrachloride-induced liver toxicity. Conclusion: The results obtained showed that methanol extract of Portulaca oleracea Linn. possesses significant DPPH free radical scavenging and hepatoprotective potential.

scholarly journals Wild Cinchona (Neolamarckia cadamba) – Bioactivities of a Medicinal Plant of Bangladesh

2016 ◽  
Vol 19 (1) ◽  
pp. 32-36
Author(s):  
Faiza Tahia ◽  
Mohidur Rahman ◽  
Marzia Bilkiss ◽  
Md Al Amin Sikder ◽  
Mohammad A Rashid
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Methanolic Extract ◽  
Soluble Fraction ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Clot Lysis ◽  
Hypotonic Solution ◽  
Vincristine Sulphate

The methanol extract of bark of Neolamarckia cadamba (Roxb.) and its organic and aqueous soluble partitionates were subjected to assays for antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial and analgesic activities. In the DPPH free radical scavenging assay, the pet ether and carbon tetra chloride soluble partitionate of the methanolic extract demonstrated the highest free radical scavenging activity with IC50 values of 60.46 ?g/ml and 78.58 ?g/ml, respectively. On the other hand, the carbon tetrachloride and pet ether soluble fractions displayed the potential lethality to brine shrimps, having LC50 of 7.24 and 7.89 ?g/ml, as compared to standard vincristine sulphate (LC50 value of 0.45 ?g/ml). During assay for thrombolytic property, the carbon tetrachloride and aqueous soluble materials revealed 66.36 % and 64.25 % clot lysis of human blood, respectively. In the membrane stabilizing assay, the carbon tetrachloride soluble fraction inhibited 86.79 % haemolysis of human RBCs in hypotonic solution-induced condition, while the aqueous soluble partitionate inhibited 92.39 % haemolysis of RBCs in the heat-induced condition. The crude methanolic extract of bark of N. cadamba showed significant central and peripheral analgesic activity at both 200 and 400 mg/kg body weight, whereas its chloroform soluble fraction mildly inhibited the growth of test microorganisms. Therefore, our studies suggest that wild cinchona should be subjected to extensive phytopharmacological investigation.Bangladesh Pharmaceutical Journal 19(1): 32-36, 2016

scholarly journals Studies of Bioactivities of Adansonia digitata (L.)

2016 ◽  
Vol 14 (2) ◽  
pp. 157-162
Author(s):  
Faiza Tahia ◽  
Priyanka Majumder ◽  
Md Al Amin Sikder ◽  
Mohammad A Rashid
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Crude Extract ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Clot Lysis ◽  
Hypotonic Solution ◽  
Adansonia Digitata ◽  
Lc50 Value ◽  
Vincristine Sulphate

The methanol extracts of leaves and barks of Adansonia digitata (L.) and their organic and aqueous soluble partitioning materials were evaluated for antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial, analgesic, and antidiarrhoel activities. In the DPPH free radical scavenging assay, the aqueous soluble materials of bark and leaves of A. digitata displayed the highest free radical scavenging activity with IC50 values of 2.21 ?g/ml and 7.70 ?g/ml, respectively while the crude extract of leaves and its pet ether soluble fraction showed significant lethality to brine shrimps having LC50 value of 6.99 and 0.284 ?g/ml, respectively as compared to standard vincristine sulphate (LC50 value of 0.44 ?g/ml). During assay for thrombolytic activity of human blood clot, the carbon tetrachloride soluble partitionate of leaves of A. digitata revealed 48.11% clot lysis. In the membrane stabilizing assay, the carbon tetrachloride- and aqueous-soluble fractions of methanol extract of leaves inhibited 61.52 % and 16.03 % hypotonic solution- and heat-induced haemolysis of RBCs, respectively. The methanolic extracts of leaves and barks of A. digitata revealed significant central and peripheral analgesic activity at 200 and 400 mg/kg body weight. The crude extract of leaves of A. digitata also displayed significant antidiarrhoel but mild antibacterial activities.Dhaka Univ. J. Pharm. Sci. 14(2): 157-162, 2015 (December)

scholarly journals Free Radical Scavenging, Membrane Stabilizing and Thrombolytic Potentials of the Leaves of Quisqualis indica (L.)

2021 ◽  
Vol 24 (2) ◽  
pp. 99-104
Author(s):  
Farhana Ahmed ◽  
Fahima Aktar ◽  
Mohammad A Rashid ◽  
Mohammad Sharifur Rahman
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Radical Scavenging ◽  
Pharmaceutical Journal ◽  
Free Radical Scavenging ◽  
Hypotonic Solution ◽  
Systematic Screening ◽  
Aqueous Fraction ◽  
Biological Potential ◽  
Natural Drugs

Bangladesh is a land of thousands of plants which might provide a scope to obtain therapeutically important natural drugs. Systematic screening of plants is very vital to fulfill this goal. Quisqualis indica (L.) is a vine and it belongs to the Combretaceae family. It grows all over the Bangladesh. It has some local uses to treat headache, skin disease, diarrhea, fever, cough, etc. In order to assess its biological potential, the leaves of the plant were collected and subjected to methanol extraction followed by fractionating into petroleum ether, carbon tetrachloride, chloroform and aqueous soluble materials. Primary free radical scavenging power of the extractives was evaluated using the radicals generated by DPPH and H2O2. Methanol crude extract as well as aqueous and chloroform fractions showed noticeable radical scavenging potential. Besides, these extracts had higher level of phenolics. The membrane stabilizing potential of the extractives was estimated based on the prevention of hemolysis of RBC prompted by hypotonic solution as well as heat. The aqueous fraction showed the highest level of membrane stabilizing potential indicating its primary anti-inflammatory ability. The extractives were also subjected to thrombolytic study. Mild thrombolytic ability was displayed by them compared to the standard. Further studies are required to explore bioactive compounds. Bangladesh Pharmaceutical Journal 24(2): 99-104, 2021

Sign in / Sign up

Export Citation Format

Share Document