A model for the hydrogen-bonding interactions between adenosine receptor ligands and histidyl residues in the adenosine A1 receptor binding site, based on AMI calculations

1991 ◽  
Vol 231 ◽  
pp. 175-184 ◽  
Author(s):  
Eleonora M. Van Der Wenden ◽  
Philip J.M. Van Galen ◽  
Adriaan P. Ijzerman ◽  
Willem Soudijn
Keyword(s):  
Hydrogen Bonding ◽  
Binding Site ◽  
Receptor Binding ◽  
Adenosine Receptor ◽  
Receptor Ligands ◽  
Receptor Binding Site ◽  
Hydrogen Bonding Interactions ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Adenosine Receptor Ligands

N-Substituted Quinazolin- 2,4-diones as Adenosine Receptor Ligands

2010 ◽  
Vol 3 (2) ◽  
pp. 1015-1021
Author(s):  
Shireesha B ◽  
G.V. Kumar ◽  
V M Reddy ◽  
Raghuprasad M ◽  
A R Rao
Keyword(s):  
Receptor Binding ◽  
Adenosine Receptor ◽  
Antagonistic Activity ◽  
Mice Model ◽  
Receptor Ligands ◽  
Binding Studies ◽  
A2a Receptor ◽  
A1 Receptor ◽  
Adenosine Receptor Ligands ◽  
Adenosine A2a

Six new N-substituted quinazolinones were synthesized and evaluated for their adenosine antagonistic activity using allergic mice model where 1, 3-dibenzyl and 1, 3-dibutyl-quinazolindiones were found to be potent than 1, 3-dimethylanalogues. They were not significant in controlling the neutrophil and lymphocyte count but effective in controlling the eosinophil influx. In adenosine receptor binding studies, 1,3-dimethyl and 1,3-dibutyl derivatives were found to have significant adenosine A1 receptor binding efficiency with Ki values 9nM and 10nM, respectively, while 1,3- dibenzyl-quinazolinone was found to have significant binding to adenosine A2A receptor showing the influence of alkyl and aralkyl groups present in these compounds. Thus, the present work indicates the possibility to explore quinazolindiones as adenosine receptor ligands.

scholarly journals Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands

2004 ◽  
Vol 12 (9) ◽  
pp. 2021-2034 ◽  
Author(s):  
Susanna Tchilibon ◽  
Soo-Kyung Kim ◽  
Zhan-Guo Gao ◽  
Brian A Harris ◽  
Joshua B Blaustein ◽  
...  
Keyword(s):  
Binding Site ◽  
Receptor Binding ◽  
Adenosine Receptor ◽  
Receptor Binding Site ◽  
A3 Adenosine Receptor ◽  
Adenosine Derivatives

scholarly journals Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain

2014 ◽  
Vol 39 (13) ◽  
pp. 2989-2999 ◽  
Author(s):  
Christa Hohoff ◽  
Valentina Garibotto ◽  
David Elmenhorst ◽  
Anna Baffa ◽  
Tina Kroll ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Adenosine Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor ◽  
Receptor Gene Polymorphisms

Pharmacology and Therapeutic Applications of A1 Adenosine Receptor Ligands

2003 ◽  
Vol 3 (4) ◽  
pp. 369-385 ◽  
Author(s):  
Arvinder Dhalla ◽  
John Shryock ◽  
Revati Shreeniwas ◽  
Luiz Belardinelli
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A1 Adenosine Receptor ◽  
Therapeutic Applications ◽  
Adenosine Receptor Ligands

Recent Advances on QSAR-Based Profiling of Agonist and Antagonist A3 Adenosine Receptor Ligands

2013 ◽  
Vol 13 (9) ◽  
pp. 1048-1068 ◽  
Author(s):  
Changliang Deng ◽  
Feng Luan ◽  
Maykel Cruz- Monteagudo ◽  
Fernanda Borges ◽  
M. Natalia D. S. Cordeiro
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
Recent Advances ◽  
A3 Adenosine Receptor ◽  
Agonist And Antagonist ◽  
Adenosine Receptor Ligands
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