Genetics in Alzheimer's disease: methodological problems, research strategies, and practical applications

1986 ◽  
Vol 7 (6) ◽  
pp. 479-480 ◽  
Author(s):  
Laurie Barclay
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Research Strategies ◽  
Practical Applications ◽  
Methodological Problems

Alzheimer’s Disease and Retinal Degeneration: A Glimpse at Essential Trace Metals in Ocular Fluids and Tissues

2020 ◽  
Vol 16 (12) ◽  
pp. 1073-1083 ◽  
Author(s):  
Alessandra Micera ◽  
Luca Bruno ◽  
Andrea Cacciamani ◽  
Mauro Rongioletti ◽  
Rosanna Squitti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Trace Metals ◽  
Late Onset ◽  
Current Knowledge ◽  
Pathological Condition ◽  
Retinal Disease ◽  
Cellular Aging ◽  
Research Strategies ◽  
Aged People

Background: Life expectancy is increasing all over the world, although neurodegenerative disorders might drastically affect the individual activity of aged people. Of those, Alzheimer’s Disease (AD) is one of the most social-cost age-linked diseases of industrialized countries. To date, retinal diseases seem to be more common in the developing world and characterize principally aged people. Agerelated Macular Degeneration (AMD) is a late-onset, neurodegenerative retinal disease that shares several clinical and pathological features with AD, including stress stimuli such as oxidative stress, inflammation and amyloid formations. Method: In both diseases, the detrimental intra/extra-cellular deposits have many similarities. Aging, hypercholesterolemia, hypertension, obesity, arteriosclerosis and smoking are risk factors to develop both diseases. Cellular aging routes have similar organelle and signaling patterns in retina and brain. The possibility to find out new research strategies represent a step forward to disclose potential treatment for both of them. Essential trace metals play critical roles in both physiological and pathological condition of retina, optic nerve and brain, by influencing metabolic processes chiefly upon complex multifactorial pathogenesis. Conclusion: Hence, this review addresses current knowledge about some up-to-date investigated essential trace metals associated with AD and AMD. Changes in the levels of systemic and ocular fluid essential metals might reflect the early stages of AMD, possibly disclosing neurodegeneration pathways shared with AD, which might open to potential early detection.

Alzheimer's Disease: Relationship of Cognition and Behavior to Neurochemistry

1992 ◽  
Vol 4 (3) ◽  
pp. 71-78 ◽  
Author(s):  
Peter J. Whitehouse
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neural Systems ◽  
Neurotransmitter Systems ◽  
Methodological Problems ◽  
Behavioral Impairments ◽  
And Behavior ◽  
Relationship Of

Alzheimer's disease is characterized by loss of cells and synapses in specific neural systems. The development of more effective therapies will depend on understanding the relationships between this pathology and the cognitive and behavioral impairments. In this review, focusing primarily on work in our laboratory, we will examine both classic and neuropeptide neurotransmitter systems and will discuss conceptual and methodological problems in relating clinical and biological measures.

scholarly journals Conceptual and Methodological Pitfalls in Experimental Studies: An Overview, and the Case of Alzheimer’s Disease

2021 ◽  
Vol 14 ◽  
Author(s):  
Daniela Puzzo ◽  
Fiorenzo Conti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Scientific Method ◽  
Life Sciences ◽  
Experimental Studies ◽  
Scientific Investigations ◽  
Disease Research ◽  
Funding Agencies ◽  
New Knowledge ◽  
Methodological Problems

The main goal of scientific research is to uncover new knowledge to understand reality. In the field of life sciences, the aim of translational research—to transfer results “from bench to bedside”—has to contend with the problem that the knowledge acquired at the “bench” is often not reproducible at the “bedside,” raising the question whether scientific discoveries truly mirror the real world. As a result, researchers constantly struggle to overcome the dichotomy between methodological problems and expectations, as funding agencies and industries demand expandable and quick results whereas patients, who are uninterested in the epistemological dispute, only ask for an effective cure. Despite the numerous attempts made to address reproducibility and reliability issues, some essential pitfalls of scientific investigations are often overlooked. Here, we discuss some limitations of the conventional scientific method and how researcher cognitive bias and conceptual errors have the potential to steer an experimental study away from the search for the vera causa of a phenomenon. As an example, we focus on Alzheimer’s disease research and on some problems that may have undermined most of the clinical trials conducted to investigate it.

The Theoretical and the Practical Memory Problem in the Context of the Personal Identity of a Patient Suffering from Alzheimer’s Disease – David DeGrazia’s Bioethical Standpoint

2019 ◽  
Vol 1 ◽  
pp. 313-321
Author(s):  
Maksymilian Czaja
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Personal Identity ◽  
Human Person ◽  
Moral Dilemmas ◽  
Theoretical Problem ◽  
Practical Applications ◽  
Memory Problem ◽  
Metaphysical Theory ◽  
The Subject

The presented article illustrates David DeGrazia’s bioethical standpoint regarding the theoretical and the practical problem of memory in the context of the personal identity of a patient suffering from Alzheimer's disease. The first part of the article is a presentation of the theoretical problem of memory in the context of numerical and narrative identity being the center of the metaphysical theory of the human person. The second part of the article presents a practical memory problem in the bioethical case of a patient diagnosed with early stages of Alzheimer’s disease. The American bioethicist and philosopher David DeGrazia proposes that the theoretical solutions regarding the identity of the human person find their practical application in bioethics in resolving moral dilemmas in the health care. The final part of the article focuses on criticizing the possibilities of practical applications of theoretical solutions on the subject of the human person in the bioethical position of David DeGrazia.

Humour, irony and sarcasm in severe Alzheimer's dementia – a corrective to retrogenesis?

2010 ◽  
Vol 31 (2) ◽  
pp. 328-346 ◽  
Author(s):  
INGER MOOS
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Communicative Competence ◽  
Nursing Home Residents ◽  
Speech And Language ◽  
Research Strategies ◽  
Language Abilities ◽  
Discussion Section ◽  
Care Givers ◽  
The People

ABSTRACTRetrogenesis is claimed to be the process by which degenerating mechanisms in the brain, as found in Alzheimer's disease (AD), reverse the order of acquisition of functions, including language, in normal child development. In FAST (Functional Assessment Staging of Alzheimer's disease) stages of AD are translated into corresponding developmental ages. Humour, irony and sarcasm are communicative strategies linked to meta-linguistic abilities developed late in childhood. If found in the conversation of people with moderately severe AD according to FAST, this could be an indication of problems in the FAST scale and subsequently in the concept of retrogenesis concerning speech and language abilities. Comprehensive, open-ended, naturalistic conversations between three nursing home residents with moderately severe AD according to FAST and their professional care-givers were analysed with concepts developed in linguistics as to the occurrence of humour, irony and sarcasm. Although the data material was limited, the findings indicate an unexpected communicative competence of the three participants. This is a corrective to retrogenesis and a caveat for poor expectations of intelligible conversations with demented people for professionals and the people they advise. Implications for research strategies and for the general knowledge of communicative competence in AD are addressed in the discussion section, and possible ways of elucidating deterioration of speech and language abilities in AD are suggested.

Behavioral Approaches to the Treatment of Alzheimer's Disease: Research Strategies

1996 ◽  
Vol 8 (S1) ◽  
pp. 7-12 ◽  
Author(s):  
Teresa S. Radebaugh ◽  
Neil Buckholtz ◽  
Zaven Khachaturian
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Long Range ◽  
Human Services ◽  
Fiscal Year ◽  
Research Strategies ◽  
Senate Committee ◽  
Health And Human Services ◽  
Disease Research ◽  
The U.S

The U.S. Senate Committee for Appropriations (for the Departments of Labor, Health and Human Services, and Education and Related Agencies), in its report of the fiscal year 1994 appropriations bill, directed the National Institute on Aging (NIA) to develop a long-range plan for taking advantage of scientific opportunities in Alzheimer's disease (AD) research.

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