Multiple cancers of the upper aero-digestive tract: the challenge of risk factor identification

1991 ◽  
Vol 60 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Eduardo L. Franco
Keyword(s):  
Risk Factor ◽  
Digestive Tract ◽  
Multiple Cancers

Clinical features of inflammatory bowel disease combined with severe complications: a retrospective study of hospitalized patients

2019 ◽  
Author(s):  
Shanbing Yang ◽  
Lei Li ◽  
Shuwen Du ◽  
Limin Zhang ◽  
Xin Fan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Risk Factor ◽  
Digestive Tract ◽  
Bowel Disease ◽  
Independent Risk Factor ◽  
Population Characteristics ◽  
Onset Age ◽  
Western Countries ◽  
Tract Perforation ◽  
Inflammatory Bowel

Abstract Background The population characteristics of Inflammatory Bowel Disease (IBD) in China are different from those of western countries, and this population lacks large sample clinical data. This study aimed to analyze the clinical characteristics of inpatients with severe complications of IBD in our center. Methods In this study, medical records of 510 hospitalized IBD patients (excluding pediatrics) were included, digestive tract perforation, massive digestive tract hemorrhage, thrombosis, toxic megacolon, digestive tract fistula, digestive tract stenosis, severe malnutrition, severe infection, and carcinogenesis were defined as severe complications. The clinical process and follow-up were retrospectively analyzed. Results The incidence of severe complications in patients with IBD was 39.02%, 71.31%, 23.81% and 50.68% for CD, UC and IBDU, respectively, and the incidence of severe complications in CD was significantly higher than that in UC (P<0.005). The cumulative incidence of serious complications in IBD patients with the course of 0-10 years was 36.99%, which was significantly lower than 48.35% of the course of >10 years (χ2=4.054, P=0.044). The incidence of carcinogenesis in UC patients with the course of 0-10 years was 1.56%, which was significantly lower than 8.47% of UC patients with the course of >10 years (P<0.01). The incidence of severe complications of UC patients with onset age ≥50 years old was 37.18%, which was significantly higher than 19.00% of that with onset age 20-49 years (P=0.001). The surgical rate of IBD patients was 10.39%, the surgical rate of CD patients was 27.87%, which was significantly higher than 5.08% of UC patients and 4.11% of IBDU patients (P<0.001), and the mortality rate of IBD patients was 1.57%, that of CD and UC was 3.28% and 1.27%, respectively. Conclusions Compared with western countries, IBD patients in China have similar incidence of severe complications, but the surgical rate was lower and the prognosis was better. The onset age ≥50 years old may be an independent risk factor for severe complications of UC patients, and the disease course of > for 10 years is an independent risk factor for carcinogenesis of UC patients.

MDM2 SNP309 is an ethnicity-dependent risk factor for digestive tract cancers

Tumor Biology ◽  
2013 ◽  
Vol 35 (4) ◽  
pp. 3431-3438 ◽  
Author(s):  
Bo Chen ◽  
Lei Cao ◽  
Kong-Wang Hu ◽  
Jia-Wei Zhang ◽  
Xiang-Ling Meng ◽  
...  
Keyword(s):  
Risk Factor ◽  
Digestive Tract ◽  
Mdm2 Snp309

scholarly journals Stress and stress-induced disorders in children

2018 ◽  
pp. 110-116
Author(s):  
I. N. Zakharova ◽  
T. M. Tvorogova ◽  
I. I. Pshenichnikova ◽  
V. I. Svintsitskaya ◽  
L. L. Stepurina
Keyword(s):  
Risk Factor ◽  
Stress Response ◽  
Infectious Diseases ◽  
Digestive Tract ◽  
Exponential Growth ◽  
Magnesium Deficiency ◽  
Adaptive Mechanism ◽  
Pathological Conditions ◽  
Oncological Diseases ◽  
Genetically Determined

Stress is one of the main reasons for the exponential growth of most chronic non-infectious diseases. The stress response is a genetically determined nonspecific adaptive mechanism. However, if it is an overly intense and prolonged, it becomes a risk factor for the pathogenesis of cardiovascular and oncological diseases, immunodeficiencies, digestive tract diseases and other pathological conditions. Studies have shown that magnesium deficiency, which develops against the background of stress, repeatedly intensifies its negative manifestations. Magnesium preparations make up the basis of therapeutic and rehabilitation activities in children experiencing stress. Timely correction of magnesium deficiency can increase the resistance against the action of stressors, neutralize or mitigate their damaging effect, and also prevent the development of stress-induced pathology.

scholarly journals Type II Diabetes Mellitus - Associated Risk Factor in the Onset and Evolution of Digestive Tract Carcinoma

2019 ◽  
Vol 24 (1) ◽  
pp. 140-146 ◽  
Author(s):  
CORNELIA NITIPIR ◽  
◽  
MARIA ALEXANDRA BARBU ◽  
CRISTINA ORLOV ◽  
ADINA ELENA STANCIU ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Digestive Tract ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

scholarly journals In-Silico Multi-Omics Analysis of the Functional Significance of Calmodulin 1 in Multiple Cancers

2022 ◽  
Vol 12 ◽  
Author(s):  
Maolin Yao ◽  
Lanyi Fu ◽  
Xuedong Liu ◽  
Dong Zheng
Keyword(s):  
Dna Methylation ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Multivariate Analyses ◽  
Main Tool ◽  
Roc Curves ◽  
Immune Infiltration ◽  
Tnm Model ◽  
Multiple Cancers ◽  
Human Cancers

Aberrant activation of calmodulin 1 (CALM1) has been reported in human cancers. However, comprehensive understanding of the role of CALM1 in most cancer types has remained unclear. We systematically analyzed the expression landscape, DNA methylation, gene alteration, immune infiltration, clinical relevance, and molecular pathway of CALM1 in multiple cancers using various online tools, including The Cancer Genome Atlas, cBioPortal and the Human Protein Atlas databases. Kaplan–Meier and receiver operating characteristic (ROC) curves were plotted to explore the prognostic and diagnostic potential of CALM1 expression. Multivariate analyses were used to evaluate whether the CALM1 expression could be an independent risk factor. A nomogram predicting the overall survival (OS) of patients was developed, evaluated, and compared with the traditional Tumor-Node-Metastasis (TNM) model using decision curve analysis. R language was employed as the main tool for analysis and visualization. Results revealed CALM1 to be highly expressed in most cancers, its expression being regulated by DNA methylation in multiple cancers. CALM1 had a low mutation frequency (within 3%) and was associated with immune infiltration. We observed a substantial positive correlation between CALM1 expression and macrophage and neutrophil infiltration levels in multiple cancers. Different mutational forms of CALM1 hampered immune cell infiltration. Additionally, CALM1 expression had high diagnostic and prognostic potential. Multivariate analyses revealed CALM1 expression to be an independent risk factor for OS. Therefore, our newly developed nomogram had a higher clinical value than the TNM model. The concordance index, calibration curve, and time-dependent ROC curves of the nomogram exhibited excellent performance in terms of predicting the survival rate of patients. Moreover, elevated CALM1 expression contributes to the activation of cancer-related pathways, such as the WNT and MAPK pathways. Overall, our findings improved our understanding of the function of CALM1 in human cancers.

scholarly journals Gastrointestinal Bleeding Is an Independent Risk Factor for Poor Prognosis in GIST Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Qi Liu ◽  
Yuji Li ◽  
Ming Dong ◽  
Fanmin Kong ◽  
Qi Dong
Keyword(s):  
Risk Factor ◽  
Gastrointestinal Bleeding ◽  
Retrospective Analysis ◽  
Digestive Tract ◽  
Gastrointestinal Hemorrhage ◽  
Gastrointestinal Stromal Tumors ◽  
Poor Prognosis ◽  
Independent Risk Factor ◽  
Stromal Tumors

A retrospective analysis of prognosis of GIST was used to assess the prognostic effects of hemorrhage of digestive tract induced by mucosal invasion of primary gastrointestinal stromal tumors and related mechanisms. The conclusion is that GISTs with gastrointestinal hemorrhage are more likely to recur, which indicates poor prognosis. Therefore, gastrointestinal hemorrhage may be used as a significant indicator to assess the prognosis of patients.

scholarly journals BCAT1 : A risk factor in multiple cancers based on a pan‐cancer analysis

2022 ◽  
Author(s):  
Guo‐Sheng Li ◽  
He‐Qing Huang ◽  
Yao Liang ◽  
Qiu‐Yu Pang ◽  
Hao‐Jia Sun ◽  
...  
Keyword(s):  
Risk Factor ◽  
Multiple Cancers ◽  
Pan Cancer
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