Correlation between low-temperature immunosuppression and the absence of unsaturated fatty acid synthesis in murine T cells

1991 ◽  
Vol 100 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Thomas M. Buttke ◽  
Meng-Chun Wang Yang ◽  
Steve Van Cleave ◽  
Norman W. Miller ◽  
L. William Clem
Keyword(s):  
T Cells ◽  
Fatty Acid ◽  
Low Temperature ◽  
Fatty Acid Synthesis ◽  
Unsaturated Fatty Acid ◽  
Acid Synthesis

scholarly journals Highly unsaturated fatty acid synthesis in vertebrates: New insights with the cloning and characterization of a Δ6 desaturase of Atlantic salmon

Lipids ◽  
2005 ◽  
Vol 40 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Xiaozhong Zheng ◽  
Douglas R. Tocher ◽  
Cathryn A. Dickson ◽  
J. Gordon Bell ◽  
Alan J. Teale
Keyword(s):  
Fatty Acid ◽  
Atlantic Salmon ◽  
Fatty Acid Synthesis ◽  
Unsaturated Fatty Acid ◽  
Acid Synthesis ◽  
Highly Unsaturated Fatty Acid ◽  
Δ6 Desaturase

scholarly journals Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+T cells

Immunology ◽  
2015 ◽  
Vol 146 (2) ◽  
pp. 292-300 ◽  
Author(s):  
Theodoros Eleftheriadis ◽  
Georgios Pissas ◽  
Georgia Antoniadi ◽  
Vassilios Liakopoulos ◽  
Ioannis Stefanidis
Keyword(s):  
T Cells ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Cd4 T Cells ◽  
Acid Synthesis ◽  
General Control ◽  
Key Enzymes ◽  
Indoleamine 2,3 Dioxygenase

scholarly journals Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection

2017 ◽  
Vol 200 (2) ◽  
pp. 643-656 ◽  
Author(s):  
Samad A. Ibitokou ◽  
Brian E. Dillon ◽  
Mala Sinha ◽  
Bartosz Szczesny ◽  
Añahi Delgadillo ◽  
...  
Keyword(s):  
T Cells ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Chronic Infection ◽  
Acid Synthesis ◽  
Effector T Cells ◽  
Early Inhibition

Mechanistic diversity and regulation of Type II fatty acid synthesis

2002 ◽  
Vol 30 (6) ◽  
pp. 1050-1055 ◽  
Author(s):  
H. Marrakchi ◽  
Y.-M. Zhang ◽  
C. O. Rock
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Unsaturated Fatty Acid ◽  
Fatty Acid Synthase ◽  
Fatty Acid Biosynthesis ◽  
Specific Interaction ◽  
Acid Synthesis ◽  
Protein Crystal ◽  
Type Ii ◽  
Acid Biosynthesis

Fatty acid biosynthesis is catalysed in most bacteria by a group of highly conserved proteins known as the Type II fatty acid synthase (FAS) system. The Type II system organization is distinct from its mammalian counterpart and offers several unique sites for selective inhibition by antibacterial agents. There has been remarkable progress in the understanding of the genetics, biochemistry and regulation of Type II FASs. One important advance is the discovery of the interaction between the fatty acid degradation regulator, FadR, and the fatty acid biosynthesis regulator, FabR, in the transcriptional control of unsaturated fatty acid synthesis in Escherichia coli. The availability of genomic sequences and high-resolution protein crystal structures has expanded our understanding of Type II FASs beyond the E. coli model system to a number of pathogens. The molecular diversity among the pathway enzymes is illustrated by the discovery of a new type of enoyl-reductase in Streptococcus pneumoniae [enoyl-acyl carrier protein (ACP) reductase II, FabK], the presence of two enoyl-reductases in Bacillus subtilis (enoyl-ACP reductases I and III, FabI and FabL), and the use of a new mechanism for unsaturated fatty acid formation in S. pneumoniae (trans-2-cis-3-enoyl-ACP isomerase, FabM). The solution structure of ACP from Mycobacterium tuberculosis revealed features common to all ACPs, but its extended C-terminal domain may reflect a specific interaction with very-long-chain intermediates.

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