Quantitative analysis of γ-aminobutyric acid (GABA) receptors of purkinje cell layer from rat cerebellar slices

1990 ◽  
Vol 21 (3) ◽  
pp. 355-364 ◽  
Author(s):  
S. Hussain ◽  
J. Bagust ◽  
C.R. Gardner ◽  
R.A. Ward ◽  
R.J. Walker
Keyword(s):  
Quantitative Analysis ◽  
Purkinje Cell ◽  
Gaba Receptors ◽  
Cell Layer ◽  
Aminobutyric Acid ◽  
Purkinje Cell Layer

scholarly journals High-Frequency Organization and Synchrony of Activity in the Purkinje Cell Layer of the Cerebellum

Neuron ◽  
2008 ◽  
Vol 58 (5) ◽  
pp. 775-788 ◽  
Author(s):  
Camille de Solages ◽  
Germán Szapiro ◽  
Nicolas Brunel ◽  
Vincent Hakim ◽  
Philippe Isope ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
High Frequency ◽  
Cell Layer ◽  
Purkinje Cell Layer

scholarly journals Cerebellar Cortex, Purkinje Cell Layer

2008 ◽  
Author(s):  
Emily Wright ◽  
◽  
Lydia Ng ◽  
Angela Guillozet-Bongaarts
Keyword(s):  
Purkinje Cell ◽  
Cerebellar Cortex ◽  
Cell Layer ◽  
Purkinje Cell Layer

scholarly journals Modeling the Encoding of Saccade Kinematic Metrics in the Purkinje Cell Layer of the Cerebellar Vermis

2019 ◽  
Vol 12 ◽  
Author(s):  
Hari Teja Kalidindi ◽  
Thomas George Thuruthel ◽  
Cecilia Laschi ◽  
Egidio Falotico
Keyword(s):  
Purkinje Cell ◽  
Cell Layer ◽  
Cerebellar Vermis ◽  
Purkinje Cell Layer

scholarly journals Mapping Purkinje Cell Placement Along the Purkinje Cell Layer: an Analysis of Postmortem Tissue from Essential Tremor Patients vs. Controls

2015 ◽  
Vol 15 (6) ◽  
pp. 726-731 ◽  
Author(s):  
Elan D. Louis ◽  
Daniel Rabinowitz ◽  
Matthew Choe ◽  
William J. Tate ◽  
Geoffrey C. Kelly ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Cell Layer ◽  
Purkinje Cell Layer ◽  
Cell Placement

Determination of Proliferative, Cytostatic Chraracteristics of Methylcobalamin on Distrorted Purkinje Cell Layer of Cerebellum

2021 ◽  
Vol 15 (8) ◽  
pp. 1790-1792
Author(s):  
Madiha Imtiaz ◽  
Tazeen Kohari ◽  
Farah Malik ◽  
Aftab Ahmad
Keyword(s):  
Purkinje Cell ◽  
Purkinje Cells ◽  
Cell Layer ◽  
Neuronal Tissue ◽  
Beneficial Effects ◽  
Purkinje Cell Layer ◽  
Recorded Data ◽  
Motor Movements ◽  
The Masses

Background: The cerebellum principally the motor organ is involved in the regulation of muscular tone and skilled motor movements. The cerebellar histology consists of three layers and the middle is the Purkinje cell layer which consists of pyramidal shaped purkinje cells. Clinical research shows scanty literature on the beneficial effects of Methylcobalamin on Purkinje cells layer. Aim: Our aim was to bring to light the need for prescribing Methylcobalamin in the masses and patient suffering from motor incoordination. Method: 15 animals were given Methylcobalamin and the changes in the thickness of Purkinje cell layer ware recorded at twelve weeks Result: The morphometric analysis showed restored thickness of Purkinje cell layer Conclusion: The recorded data of the regenerated purinje cell layer thickness proved that the use of Methylcobalamin is mandatory as protective drug in damaged neuronal tissue. Key words: Proliferative, Cytostatic, Purkine cell layer

scholarly journals Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus

2014 ◽  
Vol 369 (1654) ◽  
pp. 20130602 ◽  
Author(s):  
Simon Höft ◽  
Stephanie Griemsmann ◽  
Gerald Seifert ◽  
Christian Steinhäuser
Keyword(s):  
Ampa Receptors ◽  
Indirect Effects ◽  
Gaba Receptors ◽  
Brain Regions ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Functional Heterogeneity ◽  
Rt Pcr ◽  
Ventrobasal Thalamus ◽  
The Impact

Astrocytes may express ionotropic glutamate and gamma-aminobutyric acid (GABA) receptors, which allow them to sense and to respond to neuronal activity. However, so far the properties of astrocytes have been studied only in a few brain regions. Here, we provide the first detailed receptor analysis of astrocytes in the murine ventrobasal thalamus and compare the properties with those in other regions. To improve voltage-clamp control and avoid indirect effects during drug applications, freshly isolated astrocytes were employed. Two sub-populations of astrocytes were found, expressing or lacking α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. AMPA receptor-bearing astrocytes displayed a lower Kir current density than cells lacking the receptors. In contrast, all cells expressed GABA A receptors. Single-cell RT-PCR was employed to identify the receptor subunits in thalamic astrocytes. Our findings add to the emerging evidence of functional heterogeneity of astrocytes, the impact of which still remains to be defined.

Depression: An insight into Heterocyclic and Cyclic Hydrocarbon Compounds inspired from Natural Sources

2021 ◽  
Vol 19 ◽  
Author(s):  
Abdul Jalil Shah ◽  
Reyaz Hassan Mir ◽  
Roohi Mohi-ud-din ◽  
Faheem Hyder Pottoo ◽  
Mubashir Hussain Masoodi ◽  
...  
Keyword(s):  
Gaba Receptors ◽  
Herbal Medicines ◽  
Aminobutyric Acid ◽  
Cyclic Hydrocarbon ◽  
Natural Sources ◽  
Drug Candidates ◽  
Signalling Molecules ◽  
Symptoms Of Depression ◽  
Insight Into

: Depression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main source for new drug candidates in depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this review is to revisit the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter depression in the CNS.

Sign in / Sign up

Export Citation Format

Share Document