Tuberous sclerosis with increasing calcification in the brain during a 15-month period: A case report

Tuberous sclerosis complex is an unusual neurocutaneous syndrome with autosomal-dominant inheritance. It is characterized by the development of benign tumors involving the brain, skin, retina, heart, kidneys, lungs, and liver. The classic triad of clinical features comprises learning disability, epilepsy and skin lesions but there is marked heterogeneity in clinical features. Here, we present a case report of a 17-old-year male with characteristic clinical and radiological features of tuberous sclerosis complex. Bangladesh J Medicine July 2022; 33(1) : 99-103

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Case report on tuberous sclerosis

Vestnik dermatologii i venerologii ◽

10.25208/vdv1211 ◽

2021 ◽

Vol 97 (2) ◽

pp. 56-60

Author(s):

Nadezhda V. Krasnova ◽

Geliya G. Gimalieva ◽

Larisa G. Sinitsyna

Keyword(s):

Case Report ◽

Early Diagnosis ◽

Ct Scan ◽

Tuberous Sclerosis ◽

Skin Lesions ◽

Visual Examination ◽

Comprehensive Examination ◽

The Face ◽

The Brain ◽

Tubular Bones

Patient M., 23 years old, consulted a dermatologist with complaints of rashes on the face, which had bothered since childhood. On objective examination, skin lesions were widespread. A visual examination revealed spots of hypopigmentation, angiofibromas of the face, shagreen fate of the skin, periungual fibromas. She was diagnosed with tuberous sclerosis. Further examination revealed a neoplasm in the brain and right kidney, damage to the lungs, tubular bones, lymphadenopathy. The patient continues to be monitored by a neurologist and therapist. Based on the results of CT scan of the chest organs, an oncologist's consultation was scheduled to conduct an oncology search. Thus, with skin manifestations characteristic of this disease, it is necessary to conduct a comprehensive examination to identify concomitant pathology and early diagnosis of complications.

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4. Tuberous Sclerosis Presenting as a Suspicious Sudden Death — A Case Report and Review of Sudden Deaths in Epilepsy

Medicine Science and the Law ◽

10.1177/002580249203200114 ◽

1992 ◽

Vol 32 (1) ◽

pp. 61-64 ◽

Cited By ~ 7

Author(s):

Lloyd N Denmark

Keyword(s):

Case Report ◽

Sudden Death ◽

Tuberous Sclerosis ◽

Neck Muscles ◽

Idiopathic Epilepsy ◽

The Past ◽

Low Levels ◽

The Brain ◽

Caucasian Female

A case of a suspicious sudden death in a 19-year-old Caucasian female epileptic is presented The brain showed characteristic lesions of tuberous sclerosis. In most sudden deaths in idiopathic epilepsy no causative lesion is found in the brain A review of the past five years' cases attributed to sudden deaths in epilepsy from our department is presented, with particular reference to findings which might be construed as suspicious, e.g., signs of asphyxia and bruising in neck muscles, and to findings which support the diagnosis, e.g. biting of the tongue, voiding of urine, low levels of medication.

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Case report on tuberous sclerosis

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20171119 ◽

2017 ◽

Vol 6 (4) ◽

pp. 997

Author(s):

Zeebaish S. ◽

Hemalatha P. ◽

Anusha Y. ◽

Surendra Reddy N. ◽

Durga Prasad T. S.

Keyword(s):

Case Report ◽

Early Diagnosis ◽

Tuberous Sclerosis ◽

Female Child ◽

Skin Lesions ◽

Multisystem Disorder ◽

Three Generations ◽

Pigmented Skin Lesions ◽

The Brain

Tuberous sclerosis is a genetic multisystem disorder characterized by widespread hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung and liver. The affected genes are TSC1 and TSC2, encoding hamartin and tuberin respectively. Most features of tuberous sclerosis become evident only in childhood, limiting their usefulness for early diagnosis. We report a case of 3months old female child with seizures and hypo-pigmented skin lesions. The case is rare as it is documented in a family affected continuously in three generations involving four members.

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Clinical and Radiological Findings Related to Tuberous Sclerosis Complex: A Case Report

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-9-4-85 ◽

2008 ◽

Vol 9 (4) ◽

pp. 85-91 ◽

Cited By ~ 3

Author(s):

Siddharth Gupta ◽

Rahul Bhowate ◽

Shirish S. Degwekar

Keyword(s):

Case Report ◽

Tuberous Sclerosis ◽

Female Patient ◽

Tuberous Sclerosis Complex ◽

Complex Nature ◽

Radiological Findings ◽

Lumbosacral Region ◽

Organ Systems ◽

Dental Practitioners ◽

The Brain

Abstract Aim The aim of this report is to present the intraoral and extraoral clinical features of a young female patient with tuberous sclerosis complex (TSC) who exhibited multiple hamartomas of various organ systems including a fibromatous growth on the gingiva. Background TSC is a rare neurocutaneous syndrome exhibiting multiple hamartomatous proliferations that may involve multiple organs such as the brain, kidney, heart, eyes, lungs and skin. Oral manifestations such as enamel pitting and fibromatous growth of the gingiva are commonly seen in patients with TSC. Report A 16-year-old female patient presented with a painless interdental gingival growth in the maxillary left incisor and canine region that bled occasionally. Associated findings were adenoma sebaceum (angiofibromas) on the face, a Shagreen patch on the lumbosacral region, ash leaf spots on the trunk, and subangual fibromas (Koenen's tumor) on the nails of fingers and toes. The final diagnosis of TSC was made on the basis of the clinical findings of the skin, computerized tomography (CT) findings of the brain and kidney, ultrasonographic findings of kidney, and a histopathologic evaluation of the gingival growth which met the major and minor criteria required for a diagnosis of TSC. Summary This case report is a good example of the complex nature of patients with TSC. The diagnosis and management of these patients varies depending on the specific presentation of the disease. Dentists need to be mindful of the systemic issues as well as oral conditions related to this disease. Dental practitioners are advised to work closely with the patient's physician during treatment. Citation Gupta S, Bhowate R, Degwekar SS. Clinical and Radiological Findings Related to Tuberous Sclerosis Complex: A Case Report. J Contemp Dent Pract 2008 May; (9)4:085-091.

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